Excerpts

Most of the studies discussed above have not leveraged these recent advances, and therefore there may be significant potential to advance cervical cancer characterization by utilizing MRS.

Furthermore, the risk escalated with increasing percentages of in-field skin surface area, indicating a significant trend (P trend among exposed = 0.002).

In this regard, they assessed a significant proportion of patients reporting high levels of anxiety, depression, and psychological distress, among females and both among patients and partners, too, by assigning to the female sex a negative trend in psychological conditions among cancer patients.

Notably, PCI was found to significantly improve OS and showed a trend towards improved PFS.

The Griess reaction, ELISA, and qRT-PCR consistently pointed to a definite trend of functional remodeling and a trend towards M2 polarization of the BMDMS cocultured with GL261-GSCs exosomes ( Figure 4 d–f).

The TPS status correlated with a positive trend in ORR.

The other factor of borderline significance was older age (>65 years), which was again associated with a trend to a higher rate of mobilization failure (OR = 3.16, 95% CI 0.91 to 11.11).

While the PA may display either a heterogenous or homogenous parenchyma they have a positive trend towards developing a more heterogenic parenchyma, including the presence of calcification and necrosis, as tumor volume increases [ 24 , 25 ].

However, patients with lower CD4 stromal expression had better DSS ( p = 0.08), and the survival plots showed a curve deviation, which suggests that the results might be significant in the case of a larger study group ( Figure S1 in Supplementary Data ).

An initial phase 3 study of patients with ND-AML receiving daunorubicin and cytarabine (DA) with or without GO at a dose of 6 mg/m 2 on day 4 showed a trend toward superior survival in the DA-only group.

There was only a weakly significant positive association with incidence in men but not in women ( Supplementary Tables S3 and S7 ).

Surprisingly, our data also show discordance between the overall response rate and PFS as there was no improvement in the depth of response in our meta-analysis, even with an anti-CD38 containing regimen, while we detected a highly significant PFS advantage with the use of daratumumab.

Positive margins were associated with higher local recurrence with marginal significance in all the patients.

While the disease type ( p = 0.795) did not seem to impact on the outcome after AZA/DLI, the disease stage before transplant showed a clear trend.

The recent literature suggests an increasing trend in the development of oral cancer among rural populations around the globe [ 3 , 4 ].

Statistical analysis revealed that the differences in RFS, DDFS, OS, and BCSS between the SLNB and ALND groups were highly significant.

On the other hand, the IMpassion031 trial comparing PD-L1 inhibitor atezolizumab to placebo given with nab-paclitaxel-EC followed by atezolizumab or placebo after surgery did show a significant improvement in pCR, but it demonstrated only a nonsignificant improvement in EFS with a strong trend for OS [ 94 , 116 ].

A systematic review of 12 retrospective clinical trials showed only a weak trend towards lower local recurrence rates after adjuvant postoperative radiotherapy compared to surgery alone [ 89 ]. 2.8.

Although there is an increasing trend in bone recurrence with higher HER2 expression, the difference is not statistically significant, with a p -value of 0.098.

There was a positive trend towards improved outcome in CD5- patients; the 5-year survival for CD5- patients (n = 72) was 58.2% (95 CI: 46.7–72.6%) compared to 49.9% (95 CI: 39.8–62.5%) in CD5 patients ( Figure 3 B).

Additionally, in murine models, combination treatment with anti-LAG3 and anti-PD1 showed a trend toward improved survival compared to anti-LAG3 alone, and LAG3 knockout mice showed an improved response to treatment with anti-PD-1 compared to their wild-type counterparts [ 132 ].

Comparison between TURP and ThuLEP: Patients with Prior TURP Showed a Significant Increase in IPSS and QoL Immediately Post-RT Patients who underwent previous TURP showed a significant IPSS increase immediately post-RT ( p = 0.02), while patients with ThuLEP showed a trend but no significant increase ( p = 0.07, Figure 1 a).

A near-significant increase in quadriceps muscle strength was observed between T1 and T2, with a p -value of 0.08.

Table 3 presents the results of the multivariate analysis, including only the variables that were found to be either significant or nearly significant.

found a decreasing trend in bacterial diversity from non-atrophic gastritis (NAG) to intestinal metaplasia (IM) and then to intestinal-type gastric cancer [ 41 , 47 , 48 , 49 , 50 , 51 ].