Similarly, analysis of clinical data from The Cancer Genome Atlas-Breast Invasive Carcinoma (TCGA-BRCA) cohort reveals a positive correlation between WWOX expression and E-cadherin levels, alongside a negative trend with fibronectin levels in TNBC samples.
For the five top selected radiomic features, we observed that they had a clear trend of either increase or decrease based on the risk of lung cancer development ( Figure 2 b), as stratified in 4 groups including the “<1-year” group for those diagnosed within a year, the “1–3 year” group for patients diagnosed between one and three years, and for “>3-year” and “>7-year” groups for individuals diagnosed after more than three and seven years, respectively.
Regarding prognostic impact, our data show a favorable trend in overall survival for patients who received targeted therapies guided by ctDNA results.
For instance, in lung adenocarcinomas, this loss of size control may be significant [ 54 ].
Overall Survival and Early Death Rate The data showed a clear trend for increasing survival probabilities for AML patients over successive decades.
Although pasireotide LAR showed a trend toward higher tumor control rates at six months, this was not statistically significant [ 82 ].
In multivariate analysis (MVA) only CIRS-G was significantly associated with pEOT, whereas ECOG PS ≥ 2 almost reached statistical significance ( Table 2 ).
In a multivariable analysis of predictors for renal decline during treatment (eGFR <50 mL/min/1.73 m 2 ), the strongest independent predictor was a baseline eGFR of ≤60 mL/min/1.73 m 2 (OR 3.72), while baseline hypertension showed a trend toward increased risk (OR 2.70).
Nevertheless, the persistence of a negative trend between IGF-1 SDS and RHI supports the hypothesis that IGF-1 deficiency may play an independent role in endothelial dysfunction.
This OS difference showed a trend, but failed to achieve statistical significance ( p = 0.058), which could in part be attributed to the limited sample size.
Although Kaplan–Meier and competing risk analyses suggested a nonsignificant trend toward slightly higher local recurrence with SS, this was offset by more competing events (non-cancer death, distant metastasis) in the MS group.
A positive trend became evident after approximately 20 operations.
When evaluating the cumulative difference between the observed number of successes and the average number of successes at each time to define the learning curve, we found a change from a decreasing trend to an increasing trend in Surgeon A on the 16th surgery ( Figure 2 ).
Consequently, we assigned up to 2 points for the mitotic rate to emphasize the highly significant association between high mitotic rate and recurrence.
There was an observed trend of longer median OS among the group of n = 8 patients receiving PRRT (271 vs. 181 months), and PFS appeared to be prolonged in those receiving PRRT following the initial diagnosis of CM (58 vs. 19 months).
Conversely, endocrine therapy showed a trend toward improved DFS but did not reach statistical significance.
Regarding the IA-assisted body composition analysis, the SMI and IMAT were associated with improved OS, while HU showed a statistical trend.
Similar dynamics were observed for body weight: a loss was recorded by day 5, followed by a positive trend of weight gain, indicating the onset of recovery and systemic compensation.
Common Themes in HRQL with Immunotherapy Use Across the different classes of ICIs, a clear trend emerges: patients’ HRQL is better preserved while on immunotherapy than the traditional cytotoxic therapies.
The raw case numbers over the years in our data show an increasing trend, consistent with international tendencies.
The comparative analysis of JSCCR 2024, NCCN 2025, and ESMO 2025 underscores a clear trend toward risk-stratified, multidisciplinary management of the lateral compartment.
Anti-PD1 therapy showed a trend toward a slowed progression of cSCC and increased CD8+ expression in preliminary single-specimen analysis.
In the DIEP cohort (n = 8), a paired samples t -test revealed a highly significant improvement in abdominal well-being following reconstruction.
The prognostic value of the sFas/sFasL ratio was found to be marginally significant ( Table 3 ).
Univariate analysis showed that CBL , NRAS , KRAS , and TP53 mutations were significantly associated with inferior overall survival, while RUNX1 had borderline significance.