Excerpts

Kaplan-Meier curves showed a trend towards worse survival in CCRCC patients with plasma sPD-1 levels below this cut-off; however, the difference did not reach statistical significance (Log-rank test, p = 0.073).

Age >66 years (HR: 1.46; 95% CI: 0.98–2.18; p = 0.061) and an Eastern Cooperative Oncology Group (ECOG) score of 2 (HR: 4.0; 95% CI: 0.95–16.84; p = 0.059) showed a trend towards an association with shorter PFS but did not reach statistical significance.

Conversely, PBMCs from all 7 tested canine lymphoma patients showed highly significant response to atezolizumab ( Figure 4 C), whereas avelumab was again ineffective ( Figure 4 D).

Therefore, there may be significant heterogeneity across patients in terms of which resistance mechanisms are at play and how they emerge and are maintained.

In the last decade, 44% of the ASCT recipients were at least 60 years of age according to data from CIBMTR, which is an encouraging trend [ 15 ].

Our preliminary data showed a trend towards increased YAP/TAZ protein expression in JAM-A overexpressing breast cancer cells ( Figure S18 ); potentially suggesting a mechanism to account for increased β-catenin expression and transcriptional activity in the JAM-overexpressing tumorigenic cellular model.

In particular, AZD-1775 response formed a highly significant (FDR = 5.6 × 10 −46 ) association with TP53 mutational status in breast cancer patients ( Figure 2 B).

In contrast to solid cancers, leukemia and non-Hodgkin’s lymphoma cases showed a trend toward an improved 30-day mortality but without statistical significance. 4.

Moreover, the tumor mRNA expression of glutathione S-reductase (GSR) and superoxide dismutase 1 (SOD1) showed a trend of increase, whereas catalase (CAT) was significantly downregulated.

The log-rank test showed a trend for both overall and disease-free survival ( p -value of 0.069 and of 0.081, respectively), indicating conformity with TCGA data.

Albeit less pronounced, similar and highly significant differences were detectable for stem-like and Paneth-like cells.

Although patients with no prior CPI showed a trend for more favorable progression-free survival relative to patients with prior CPI, the improvement in the 1-year OS did not reach the statistical threshold in this heavily treated patients.

33.8% of cases in the whole series were approached by laparoscopic technique, with an increasing trend recorded year by year (see Figure 1 c), resulting in a significant difference for the use of minimally invasive technique among the three periods analyzed (7.8% in Period 1, 30.3% in Period 2 and 58.7% in Period 3, p = 0.02).

For Caco-2 cells, the treatment time was not significant ( p > 0.05); for ECV cells, the treatment time was significant ( p = 0.0495), and an increasing trend was detectable.

Cell death became highly significant only upon treatment with 20 μM Tam, which reduced the culture viability by about 50%.

Correlations, while highly significant, were of weak to moderate strength, likely due to the small participant cohort and, in the case of the distress thermometer, the lack of granularity of the outcome measure.

Even being not significant due to the small number of cases in the ATIP1 high cohort, ATIP1 high glioma patients showed a slight trend towards a prolongated median survival (median survival not reached so far) compared to ATIP1 intermediate/low patients (48 months) ( Figure S2a ).

While the various tested combinations of MAPK associated kinases indicated mostly highly significant correlation with overall survival Figure S4B,D,F,H ), the mRNA analyses revealed an inconsistent expression pattern depending from kinase to kinase, reflecting the identified differences between SAS and UTSCC15 cell lines ( Figures S2B and S4A,C,E,G ).

While pathway activity scores between quadrant samples of a single block, and between blocks of one PT showed highly significant correlations, correlations decreased between PT and LN metastases and significance was lost.

Upon comparison of all CAFs with all NFs, the two proteins αSMA and CAV1 showed a clear trend towards increased abundance in CAFs, while CD90 was significantly enriched in NFs.

They also suggest that FUS-TB may detect higher rates of csCPa compared to COG-TB, with results approaching significance.

Borderline significant associations were found for these variables in the Trajectory-2 vs.

Surgical Morbidity and Mortality in the Resection of Brain Metastases When analyzing the frequency of surgical complications, there appears to be a positive trend along the time axis [ 71 ].

Comparison of cancer to controls was highly significant for all markers in all fractions; however, urine sediment performed best to detect CIN3.

These cumulative incidence curves demonstrated a clear trend between a higher comorbidity count and increasing other-cause mortality in all three age groups. 4.