Barely Significant

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On the other hand, a WHO progress report published in 2024 showed the challenging reality of the control of STIs; the estimated number of new syphilis cases among adults aged 15–49 years increased by over one million in 2022, reaching eight million worldwide, and gonorrhoea case notification rates in selected high-income countries showed an increasing trend [ 5 ].
For cold spots, the distribution of centers of gravity was dispersed, and their directional changes were obvious: the centers of gravity of the incidence and mortality in males showed a trend of change in the northwest-southeast direction, whereas the centers of gravity of the incidence in females first moved in the southeast-northwest direction and then in the northwest-southeast direction.
Spatial trend of ASD medical resources in Guangxi The spatial allocation of ASD medical intervention institutions showed a trend of low north and high south, ascending and then descending from west to east, as shown in Fig. 5 -a, and higher Z values in central and south-central Guangxi were observed in the 3D trend map, presented in Fig. 5 -b.