Finally, PDAPP mice showed a trend towards higher fractions of firing cells at the tested current intensities compared to littermate controls (Figure 4E ).
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Although the difference in survival outcomes between patients with GCs exhibiting loss or retention of ARID1A expression was not statistically significant, the latter group showed a trend toward better OS outcomes
Due to the small sample size of each group (10 patients), we decided to combine the two verum acupuncture groups (low and high dose groups) because (1) the total treatment time, needle stimulation time, and reported sensations were the same in both verum groups; (2) we found no clinical outcome differences between the two verum acupuncture groups and both verum acupuncture groups showed a trend towards improvement when compared to sham treatment, and (3) high and low dose acupuncture needle stimulations evoked similar activation patterns (Additional file 3 : Figure S3) ; ( 4) reported sensations as measured by MASS were similar in both real acupuncture treatment groups, and both showed significant differences from the sham acupuncture group; (5) acupuncture prescription for Knee OA varies across different studies; combining two protocols may better represent clinical acupuncture in practice; and (6) combining two groups gave us more power to test our hypothesis.
Although the number of surveillance colonoscopies showed a trend towards increasing tendency as the number of high-risk findings increased, there were no significant intergroup differences in terms of follow-up duration nor number of surveillance colonoscopies.
Both METH (25 μM) and Chlq (25 μM) showed a trend toward a reduction in NO production.
The results indicated that the water quality showed a trend of degradation from southwest to northeast, and the overall water quality level was exacerbated during the study period.
Comparison across urine BPA categories also showed a trend of higher PRL and PROG for women in the higher urine BPA categories, while only the association with PRL reached statistical significance.
Key genes for NED were clearly altered by SNAI2-siRNA treatment since the expression of CHGA was completely abolished and that of Enolase 2 ( ENO2 ) significantly ( p < 0.05) decreased, as revealed by real-time RT-PCR analyses (53%), and confirmed at protein level by Western Blotting (Figure 4 ), while the expression of synaptophysin ( SYP ) and neurogenic differentiation factor 1 ( NeuroD1 ) only showed a trend towards down-regulation (not shown).
In addition, our results also showed a trend in the relationship between the occurrence of RILI of Grade ≥2 and the Vx of the ipsilateral lung such that the lower the X value, the smaller the P -value (indicating more significance).
The KO mice treated with any dose showed a trend towards amelioration of these abnormalities in all groups [A (Fig. 1a ), B (Fig. 1b ), and C (Fig. 1c )].
Although not statistically significant, women with perinatal depression showed a trend towards higher frequency of self-reported menstrual irregularity.
The analysis of BCVA gain in patients after cataract surgery showed a trend for greater improvement in BCVA with longer follow-up.
Only the dose of morphine administered as continuous sedation showed a trend to be higher in the intervention group.
from 4 h to 8 h after trauma, but not during the initial 3-h period post-trauma induced by dropping a 450 g weight from 1 m which induces a mild injury.[ 18 ] In a separate study, Petrov et al., using a similar trauma model, reported a decrease in the cerebral blood flow by 2–3 h after trauma that showed a trend toward normalization by 4 h post-trauma.[ 19 ] Shen et al., using magnetic resonance imaging based perfusion imaging in a similar trauma model, reported reduced hippocampal cerebral blood flow at 4 h (8-14%), 24 h (8%), and 48 h post-trauma (18%), compared to their pre-injury levels.
Moreover, healthy volunteers in intermittent hypoxia (IH) condition simulating moderate OSA showed a trend of decreased insulin sensitivity and glucose effectiveness after 5 hours [ 5 ] and similar results were observed in an animal model.
An interim analysis showed that the intracoronary injection of fhADCs was feasible and safe, and showed a trend toward improved cardiac function and perfusion defects, and reduced myocardial scarring. 4 In conclusion, this study demonstrated that intracoronary administration of cultured ADSCs improved myocardial perfusion defects, reduced LV chamber dilatation and infarct area in a porcine acute MI model.
The enriched GO terms among regulated proteins showed a trend of cytokinesis of the bacteria in the biofilm, when in presence of the organotypic tissue.
Many other genes also showed a trend of differential expression but it was statistically non-significant.
While both butyrate and propionate treatment showed a trend toward enhancing the NF-kB response in response to the TLR9 agonist ODN2006 in HEK293 cells, these differences did not reach statistical significance (Figure 2 E).
Ctnnb1 (β-catenin) expression was also increased in pretumor mammary glands of HFD-LFD mice and showed a trend toward increased expression in continuous HFD mice, indicating another early effect of peripubertal exposure to HFD.
Secondly, MCV showed a trend towards microcytosis in both HIV-1-infected and uninfected infants suggesting that zidovudine was not present in sufficient quantities to induce macrocytosis, as might have been expected [ 13 ].
Data on patients aged 31–40 years showed a trend toward favorable outcome, whereas data on patients 21–30 years were clearly underpowered to draw robust conclusions ( 20 ).
Interestingly, when ignoring the familial pattern and simply comparing the clinical features between mutation positive patients with mutation negative patients, we found that the former group showed a trend for younger age and more frequent central lymph nodes involvement though they had no different in tumor size.
Meanwhile, OPD (0.75 and 1.5 g/kg), OSD (0.15 g/kg) and OSK (0.6, 1.2 and 2.4 g/kg) treatment did not show significant increase of the swimming time in mice (14.73 ± 1.28, 23.96 ± 3.70 and 27.34 ± 5.72 min, respectively) as compared to the control group ( p = 0.897, p = 0.398 and p = 0.268, respectively), but OSD (0.15 g/kg) showed a trend of increasing swimming time, but did not reveal a significant difference ( p = 0.225).
A retrospective cohort study showed a trend of decreasing prevalence in hospital-acquired and intensive care unit (ICU)-acquired ARDS patients over an eight-year period [ 11 ].