Although lysed samples in our preliminary analysis showed a trend to a lower cell count (mean count: 100.5 ± 26.4 cells vs. 159.0 ± 75.1 cells, p = 0.22) and lower RNA concentration (mean concentration: 75.5 ± 25.6 pg/μl vs. 91.5 ± 60.6 pg/μl, p = 0.65), no distinct effect of lysis on the RNA profile of hyalocytes could be inferred, as highlighted by the conducted principal component analysis (PCA, Additional File 2 A) and heatmap visualization (Additional File 2 B).
This concordance suggested that patient-specific factors influence DWEK outcomes.[ 44 ] Two series[ 40 42 ] found that nonclearing patients had the highest preoperative pachymetry, but two larger series found no association between pachymetry and time to clearance.[ 32 44 ] Our study also showed a trend toward lower preoperative peripheral ECD with increased time to clearance that was not statistically significant ( P = 0.22).
By intervention category (i.e., IPV or nicotine, alcohol, or drug dependence), women in the Intervention Group were significantly more likely to have taken steps to reduce their alcohol use (OR = 1.78), and women in the Intervention Group showed a trend towards increased probability of taking action to reduce tobacco use ( P = 0.22).
Cytomegalovirus reactivation showed a trend towards higher frequency in patients with COVID-19 (21.9% vs. 11.3%, p = 0.22).
While S259 showed a trend toward reduction in viral load, the results were not statistically significant (adjusted P = 0.22).
The OS rates were almost identical in both groups during the first 3 years and then showed a trend of improvement in the CCRT arm (68% versus 64% at 5 years and 61% versus 54% at 8 years (p=0.22).
MDT input also showed a trend toward improved outcomes (OR for cure 4.8, 95% CI 0.39–54.1, p = 0.221), but without statistical significance.
Consistent with these findings, the ruxolitinib group also showed a trend toward reduced incidence of cGVHD compared with controls (HR 0.46, 95% CI 0.14–1.48; weighted log-rank p = 0.221; Fig. 2 C).
Mepilex Ag ® showed a trend towards a shorter wound closure time (10.5 vs. 11.5 days; p = 0.223).
Granta-519 also showed a trend toward rescue with BAX knockdown ( P = .223) ( supplemental Figure 6 B), whereas neither protein knockdown rescued Maver-1 cells ( supplemental Figure 6 D).
WB of dorsal striatum lysates showed a trend for an increase in LAMP‐2 levels in mutant mice (Fig 3 G; Tor1a +/+ 1.000 ± 0.104 N = 8; Tor1a +/− 1.168 ± 0.058 N = 6; t ‐test P = 0.2232).
Analysis of individual RTI subtypes showed a trend toward shorter duration of common cold (8.88 ± 8.79 vs. 10.32 ± 8.57; P = 0.225) and tonsillopharyngitis (1.88 ± 4.12 vs. 2.67 ± 4.74; P = 0.186) in the active group (Table 2 ).
Although the Q3 group showed a trend towards a decreased mortality risk, this did not achieve statistical significance (HR 0.40, 95% CI 0.09–1.76, P =0.225), likely due to the smaller sample size of the validation cohort.
However, Mankin scores of lesioned osteochondral explants treated with hrIL11 showed a trend towards lower scores (β=-0.75, P-value = 2.25 × 10 − 1 ).
page 10 “In the model with mortality as outcome, week-2-MP patients showed a trend for lower mortality (HR 0.48, 95%CI 0.14 to 1.57, p=0.225), whilst out-of-week-2- MP patients had an increased risk of death (HR 2.49, 95%CI 0.87 to 7.11, p= 0.088), both compared with no MP patients.“ Comparison among 2-week-MP, out-of-week-2-MP and no MP patients is critical for this study.
Stent graft oversizing by ≤10% showed a trend towards fewer aortic-related events hazard ratio 0.455 (95% confidence interval 0.128–1.624, P = 0.225).
When grouping by age, sex, educational level, smoking status, and household income, the presence of MetS was identified as a significant risk factor for subsequent suicide attempt, except for current smokers, in whom MetS only showed a trend towards increasing suicide risk (P = 0.225).
Contrast efficiency showed a trend favoring the foot pedal group: 23.4±9.4 mL per vessel versus 27.4±10.4 mL per vessel in controls (P=0.226), representing a 15% reduction that did not reach statistical significance ( Table 2 ).
The MPD during slow spindles and the CAPS hyperarousal score showed a trend towards a negative correlation across participants with PTSD (Night 1: Spearman’s rho = −0.22, p = 0.226; Night 2: Spearman’s rho = −0.33, p = 0.066). 3.5 Group differences across sleep cycles We also examined group differences in the MPD during slow spindles for the Fz–C5 channel pair across the first three sleep cycles, using the combined set ( Fig. 4 ).
The summarized Z score showed a trend to more cognitive decline in the control group (2.16±5.30) compared to the RIPC group (1.14±4.02; p = 0.228).
The male BLG group also showed a trend of becoming immobile earlier, although this measurement was not statistically different from the sham group (Fig. 4 d; open vs. filled green bars, p = 0.2281; 2-way ANOVA).
The high-risk group showed a trend to a lower 3-year LFS (60.0% vs. 77.1% vs. 92.9%; P =0.229) than the intermediate- and low-risk groups ( Fig. 2 ).
In contrast to previous literature on endometrioid endometrial cancers, SFRP4 expression was similarly distributed in all histological subtypes of ovarian cancer ( Figure 4 A ), although in plasma, patients with endometrioid ovarian cancers showed a trend towards higher SFRP4 expression (N.S. p = 0.23; Figure 4 C ).
Notably, CAPN14 mRNA expression in esophageal biopsies showed a trend of being lower in patients with familial EoE than non-familial EoE ( P = 0.23) (Supplementary Fig. 11a ).
However, the lipid profile did not worsen as indicated by the TC/HDL-c ratio, that although not significant showed a trend towards decline (-0.13, 95% CI -0.34, 0.09, p = 0.23).