The patients with positive baseline ctDNA showed a trend of worse EFS (Fig. 3A , p = 0.21, HR = 3.39, 95% CI: 0.44–26.3) and DRFS (Fig. 3B , p = 0.08, HR not calculable) than the ones with negative baseline ctDNA, but the differences were not statistically significant.
Absolute values showed a trend toward lower values in the AMD-fellow group ( P = 0.21), while the AMD group, in which 7 (43.8%) eyes were measurable, did not exhibit any trend ( P = 1.00).
ORR among patients who had previously received thalidomide and those who did not receive thalidomide was 33 % (4/12 patients, all PRs) and 46 % (11/24 patients, with 1 CR and 10 PRs), respectively, with no significant difference between two groups (P = 0.72), although the latter showed a trend toward longer PFS (3.3 months versus not reached, P = 0.21).
18 The experimental arm showed a trend towards longer mOS (19.4 versus 8.9 months for FOLFIRI and placebo, one sided p = 0.21).
M-H patients showed a trend towards lower median overall survival in SqCC and ADC (75 vs 63 months p=0.21; 53 vs 50 months, p=0.14, Figure 3C,3D).
Chidamide-treated females showed a trend towards improved glucose tolerance ( t (8) = 1.38, p = 0.21), but this did not reach significance ( Figure 1 A).
Blastocyst ET showed a trend toward a higher implantation and LB rates compared with day-3 ET cycles (implantation rate: 25.6% in single day-3 ET versus 40% single blastocyst ET, P = 0.2114; LBR: 18.6% single day-3 ET versus single blastocyst ET, P = 0.7165).
When comparing the HU FMT WT and HU FMT LIPUS groups, the protein expression levels of AKT and mTOR showed a trend towards upregulation in the HU FMT LIPUS group, albeit without reaching statistical significance (( p = 0.2123, p = 0.2065, respectively).
This pattern was significant in cl 2 (one-way repeated measures ANOVA, F (2,57) = 3.6125, p = 0.033), while cl 1 showed a trend (one-way repeated measures ANOVA, F (2,57) = 1.5916, p = 0.2125).
Although low socioeconomic status showed a trend towards lower risk, it was not statistically significant ( p = 0.213).
The data in the present study also showed a trend of higher percentage of patients with chronic obstructive pulmonary disease (P = 0.215), structural heart disease (P = 0.190), and coronary artery disease (P = 0.270) in the group with prolonged QTc although not reaching the level of statistical significance due to the small numbers.
5.9%; p=0.3827) and showed a trend towards higher mortality rates (6.6% vs. 3.9%; p=0.2159) compared to non-isolated matched controls (Table 3 (Tab. 3) ).
Although intrahepatic IL-17A data for patients with MASLD included in the gut mycobiome analysis were available for only a small subset of the cohort, the results showed a trend toward a positive correlation between gut mycobiome dysbiosis and increased hepatic IL-17A levels (Spearman correlation = 0.352, p = 0.218).
Furthermore, the level of pT181-tau showed a trend-level positive correlation ( Figure 2C , P = 0.218) with advanced age.
Increasing stem size showed a trend toward reduced risk (HR 0.88, 95% CI 0.72–1.08; p = 0.218), while glenosphere size had no apparent effect on implant survival (HR 1.05, 95% CI 0.91–1.21; p = 0.512).
The anti-inflammatory properties of asiatic acid were demonstrated through significant reductions in key pro-inflammatory cytokines, including tumor necrosis factor-α (32.036 versus 55.182 in controls, p = 0.026) and interleukin-1β (86.685 versus 123.02 in controls, p = 0.016), while interleukin-6 levels showed a trend toward reduction that did not reach statistical significance (155.0 versus 215.5, p = 0.219) [ 237 ].
Patients with myosteatosis in the PD‐1 inhibitor + CTLA‐4 inhibitor group had no difference in OS ( p = 0.723) from those without and showed a trend towards improved PFS ( p = 0.219).
This concordance suggested that patient-specific factors influence DWEK outcomes.[ 44 ] Two series[ 40 42 ] found that nonclearing patients had the highest preoperative pachymetry, but two larger series found no association between pachymetry and time to clearance.[ 32 44 ] Our study also showed a trend toward lower preoperative peripheral ECD with increased time to clearance that was not statistically significant ( P = 0.22).
The RNA sequencing database from a GBM patient cohort (156 patients, four non-tumor controls) showed a trend toward upregulated expression of CCL21 ( p = 0.22, Supplemental Figure S1A ).
Although lysed samples in our preliminary analysis showed a trend to a lower cell count (mean count: 100.5 ± 26.4 cells vs. 159.0 ± 75.1 cells, p = 0.22) and lower RNA concentration (mean concentration: 75.5 ± 25.6 pg/μl vs. 91.5 ± 60.6 pg/μl, p = 0.65), no distinct effect of lysis on the RNA profile of hyalocytes could be inferred, as highlighted by the conducted principal component analysis (PCA, Additional File 2 A) and heatmap visualization (Additional File 2 B).
By intervention category (i.e., IPV or nicotine, alcohol, or drug dependence), women in the Intervention Group were significantly more likely to have taken steps to reduce their alcohol use (OR = 1.78), and women in the Intervention Group showed a trend towards increased probability of taking action to reduce tobacco use ( P = 0.22).
While S259 showed a trend toward reduction in viral load, the results were not statistically significant (adjusted P = 0.22).
Elastography The Young’s modulus showed a trend to be higher in malignant thyroid nodules (median 27.6; 25th/75th percentile 17.3/63.4) than in benign nodules (median 19.5; 25th/75th percentile 11.7/32.3) ( p = 0.22).
Relative to water (placebo) control, 0.33 mg/kg pyrantel (labeled PYR in the figure) showed no significant impact on hookworm burdens (5% reduction, P = 0.87) whereas 1 mg/kg pyrantel showed a trend toward lower burdens that was not statistically significant (39% reduction, P = 0.22; Fig 5A ; S1 Table ).
Hospitalization rate (38.6% post-NPI vs 43.9% pre-NPI) and length of stay (median, 4 [IQR, 2–5] vs 4 [IQR, 3–6] days) were similar, while generalized linear models showed a trend toward fewer hospitalizations post-NPI (odds ratio [OR], 0.72 [95% CI, 0.42–1.23]; P = 0.22).