Age showed a trend for association with individuals with both diseases (p = 0.00001; OR = 3.6, 95% C.I. 0.9-10.7) and chronic periodontitis alone (p = 0.002; OR = 3.0; 95% C.I. 0.8-10.52), suggesting that the difference in the distribution of BRINP3 alleles between healthy and individuals affected by peri-implantitis is confounded by the difference in the age of both groups (healthy individuals were on average 8 years younger than the affected individuals; Table 1 ).
Subgroup analysis of six studies with higher cumulative dose of statin use, defined as statin use over 180 cumulative defined daily doses (cDDDs) or 0.5 years (cumulative duration), showed a trend towards more risk reduction of liver cancer (RR=0.53, 0.36 to 0.79), but with a high degree of heterogeneity (I 2 =90%, p<0.00001; see online supplementary figure S7).
Males (0.249 ± 0.023, mean ± 95%CI) showed a trend towards higher BOLD activation than females (0.167 ± 0.028, p = 0.000012 by unpaired two-tailed t -test) when all nodes and subjects were assessed.
When applying a less restrictive threshold (nominal p -value < 10 −4 ), a second gene showed a trend of association: Neurocan (NCAN, p -value = 1.58 × 10 −5 ), as shown in Figure 4 .
Another correlated SNP in the same region (rs269101, r 2 = 0.42 in 1000 genomes phase3 Finnish individuals) showed a trend toward association in our GWAS ( p = 4.2 × 10 −5 ) and in the replicate ( p = 0.054), further supporting the result.
In this database, only one SNP (rs331142) in the ROBO1 gene showed a trend for association to ROBO1 expression ( p = 4.6 × 10 −5 ), but it did not reach genome-wide statistical significance (Tran et al. 2014 ).
In addition, although it was not statistically significant after correction of multiple comparison, rs2074262 showed a trend of association with mRNA expression of RAR related orphan receptor A (RORA, P = 0.00007) and somatostatin receptor 3 (SSTR3, P = 0.0001) gene in expression quatitative trait loci (eQTL) analysis using ENCODE dataset ( https://www.encodeproject.org ).
HRD-positive PDACs showed a trend towards a higher mutation number (p < 0.0001), CNV burden (p = 0.0004) and SV number (p < 0.0001) per tumor when compared to HRD-negative PDACs.
3 ), health care use for schizophrenia disorders showed a trend increase across the pandemic (+ 2.92 per month; p < 0.0001) and a delayed start to increasing in the pandemic (− 18.31; p < 0.0001).
After inhibiting TXNIP expression in mice, the HFD + nicotine (low) + si-TXNIP group showed a trend of improved atherosclerotic plaque lesions compared to the HFD + nicotine (low) group (P<0.0001).
The IL6 gene was downregulated after treatment with Fuco (20 μg/mL) ( p ≤ 0.0001) while CXCR4 showed a trend of being downregulated after 6 h of treatment with Sm ( p ≤ 0.0001). 3.9.
P14 also showed a trend of progressively increasing fatigue during AB-LT training (first vs. last condition, p < 0.0001, d = 2.93) ( Figure 2 b).
CD73 − CD8 T cells from AML patients showed a trend of higher susceptibility to apoptosis manifested by significantly higher expression of CD95 expression ( P < 0.0001, Fig. 5 c).
The meta-regression of the year over logit-transformed prevalence showed a trend towards an increasing prevalence of beta-blocker use from 1995 to 2015 with a slope of 0.1 (p<0.0001).
Odds ratios (ORs) for high SBP, high DBP and high BP were significantly greater in OW and OB children than NW group, and showed a trend increase correlating with obesity stages (all P <0.0001).
solanacearum in the rhizosphere soil showed a trend of increased firstly and then decreased with the increase of soil pH (R 2 = 0.5569, P < 0.0001, Fig. 1A ).
Results Immediately following the change to cascade reporting, FQ prescribing decreased by 38% (incidence rate ratio [IRR] 1.38; 95% confidence interval [CI] 0.50-0.77 p < 0.0001) and no change in trend was subsequently seen (IRR 1.01, 95% CI 0.98-1.04; p =0.59) (Figure 1).Cephalexin prescribing did not immediately change following the intervention (IRR 1.20, 95% CI 1.00-1.33; p =0.05) but subsequently showed a trend towards increase use (IRR 1.04, 95% CI 1.02-1.06; p < 0.0001) (Figure 1).
Furthermore in the hanging wire grip test requiring strength and coordination the FE65/FE65L1-DKO mice had a significantly lower latency to fall compared to WT mice, while single KOs, which also showed a trend towards a lower latency to fall, were not significantly different from WT mice ( Fig. 1c , p = 0.0001).
Excluding coagulase-negative staphylococci, Enterobacterales was the most frequently isolated family (49% of the cases) for the period studied and this group showed a trend to increase along the years (p<0.0001).
The observations of ΔftsZ1 , ΔcetZ5 , and ΔcetZ6 showed a trend of cells above the 2.5 μm threshold starting off significantly longer than the parental cells at the 1 h mark ( p < 0.0001), but they decreased in size and significance by the 6 h timepoint. ΔcetZ2 cells showed no significant difference in length at any of the timepoints compared to the parental cells, whereas ΔcetZ4 cells started off longer but after 1 h adopted a more parental-like phenotype.
The Cochran Armitage test showed a trend towards decreasing CT use for CD overall ( P < 0.0001) and CD induction, ( P = 0.0024).
The LF:HF ratio showed a trend toward increase in bright light compared with dim light (Interaction, p < 0.0001; Light, p = 0.056), with a significant difference in the fifth hour after lights-on ( p = 0.017) ( Fig. 3H ).
Both backbone and IL7 coding virus-treated groups showed a trend for the reduction of tumor volumes, however IL7 coding virus-treated animals had notably smaller tumors than mock and Ad5/3-E2F-d24-treated animals ( p < .0001 and p = .0463, respectively) ( Figure 1h ).
The A/California strain showed a trend characterized by two different peaks: the first in 2010/2011 (49.0%, 95% CI 39.0–59.0; p < 0.0001 vs. 2009/2010 for HI results) and the second one in 2014/2015 (53.0%, 95% CI 43.0–62.0; p = 0.004 vs. 2013/2014 for HI results).
This pattern was also true of the linear trend where this level of association was particularly apparent in relation to the high intensity angry expressions, such that the mean number of FRAXE repeats showed a trend - the more FRAXE repeats, the more likely was the boy to recognise extreme anger (P<0.0001).