“showed a trend”

Patients with mutations in the LRP2 , DAXX , and PKN1 gene showed a trend of well‐differentiated and early‐stage tumors with less metastasis ( p = 0.000).

Study 2 showed a trend toward decreased impact (1 to 10: β = −0.42, P = 0.00, P adj . = 0.051), but no significant effect was found in Study 3 (1 to 10: β = 0.11, P = 0.45, P adj . = 0.67).

The smoothed spline model showed a trend of increasing and then decreasing morbidity with increasing SDI, analysed as R = 0.582, p = 0.000.

3 B and D) showed a trend of gradually transforming from multimodal to bimodal (core–satellite mode) — the “middle sector” of species with P = 30–70% gradually disappeared from the communities.

hepatica infection, IL10, showed a trend of activation with z-score of 0.423 (overlap p-value = 3.84E-16).

And activated CD8 + T cells showed a trend of negative association with riskscore ( p = 4.3e-12, r = − 0.24) (Fig. 5 L).

In the meta-analysis, one SNP, rs3987 at 4q26, reached GWAS significant p-value (p = 4.02×10 −8 ), and one SNP pair, rs1100508 CG and rs8111948 AA, showed a trend for two-locus association (p = 4.35×10 −11 ).

Surprisingly, results corresponding to the HELPO2 family showed a trend that did not fit with a normal distribution (W = 0.727, P = 5.135 e − 10 , Fig. 1B ).

When using lifetime smoking index as exposure, the results showed a trend similar to that of the smoking initiation analysis (OR, 1.49; 95% CI, 1.31–1.70; P = 2.5 × 10 −9 ; I 2 = 37%) ( Figure 3 and Supporting Information, Figure S1 ).

Conversely, the high-risk group showed a trend of resistance to some epigenetic drugs such as LAQ824 (a histone deacetylase inhibitor) ( r = -0.272, P = 4.15 × 10−8, Cohen’s d = -0.525).

However, two variants on chromosome 17 showed a trend toward significance in the Sierra Leone cohort (Table 1 and Extended Data Fig. 2e ). rs73397758 ( P = 5.5 × 10 −8 , odds ratio (OR) = 9.16) is ~350 KB (kilobase pairs) downstream of the gene CASC17 , a long non-coding RNA named for a genetic association with prostate cancer 37 , and 570 KB upstream

Specifically, target genes of miR-30a-5p, miR-486-5p, miR-30c-2-5p, miR-205-5p, and miR-106b-3p whose expression levels showed a trend from healthy controls to MIBC patients displayed an over-representation in several KEGG pathways such as “Pathways in cancer_Homo sapiens” (hsa05200; adj p = 1.05 × 10 –7 ), “MicroRNAs in cancer_Homo sapiens” (hsa05206; adj p = 2.97 × 10 –7 ) and “Bladder cancer_Homo sapiens” (hsa05219; adj p = 3.38 × 10 –5 ).

In contrast, rs187522732, located in the intergenic region between KCNJ3 and NR4A2 , showed a trend toward a significant association (effect size = 0.0713 [SE = 0.0145], P = 9.2 × 10 −7 ) in the discovery phase, but not in the replication phase ( P = 0.51).The combined P value for this variant in the meta-analysis ( P = 8.2 × 10 −6 ) was higher than that in the discovery phase, indicating that this association is likely a false positive.

2, Supplemental digital content 3, http://links.lww.com/FPC/B116 for Manhattan and quantile–quantile plots for the total PANSS score, the positive Marder factor score, the negative Marder factor score, and CGI-S, respectively) and 20+ regions including aarF domain containing kinase 1 ( ADCK1 ) that showed a trend toward association ( P <1.0×10 −6 ).

The body mass loss on Days 3 and 7 ( Figure 2 C) was significant in both MCAO groups, and on Day 14, it was significant in the MCAO-LM group and showed a trend in the MCAO-KM animals (ANOVA: F(1,36) = 35.13, p = 0.000001), but it did not depend on the model either (ANOVA: F(1,36) = 0.104 p = 0.74; MCAO-KM vs.

African (OR, 28.7; 95% CI, 0.6–300.6; P = 4.3 × 10 −2 ) and South Asian (OR, 32.4; 95% CI, 4.5–362.0; P = 1.7 × 10 −4 ) ancestry groups showed a trend toward enrichment that did not exceed study-wide significance ( P < 2.63 × 10 −6 accounting for ∼19,000 genes).

For SNPs that reached statistical significance ( P = 5.0×10 −8 /3 = 1.67×10 −8 , to account for three main tests) or showed a trend towards that threshold ( P < 5×10 −6 ), we performed stratified G×E analyses by sex, tumor site (proximal colon, distal colon, rectum), and study design.

Kaplan-Meier analysis showed a trend for significantly shorter MST with increasing number of risk alleles for the OS in patients with HBV-related HCC (Log-rank P = 7.72×10 −6 ; Figure 2 ).

No polymorphisms with genome-wide levels of significance (P<5*10(-7)) were identified, although rs740363 showed a trend for association with HF(P=8.8*10(-6)) [ 5 ].

Using rtCGM showed a trend towards a larger effect (MD −3.95 mmol/mol [−0.36 pp], 95% CI −5.46, −2.44 mmol/mol; p <0.00001) than using isCGM (MD −1.79 mmol/mol [−0.16 pp], 95% CI −5.28, 1.69 mmol/mol; p =0.31).

Twelve novel loci showed a trend of association with V̇O 2 peak response that reached suggestive significance ( P < 1 × 10 –5 ).

For resting EF (384 patients), the weighted mean difference showed a trend of 1.9% in favor of CoQ10 (95% CI −0.13 to +3.9). 4 Upon meta-analysis, there was a 3.7% net improvement in EF (1.59 to 5.77; p < 0.00001). 35 3.4.

In this analysis too, rtCGM showed a trend towards a larger effect (MD −3.95 mmol/mol [−0.36%]; 95% CI: −5.46 to −2.44, p < 0.00001) than isCGM (MD −1.79 mmol/mol [−0.16%]; 95% CI: −5.28, 1.69, p = 0.31).

In subsequent logistic regression analyses, 31 SNPs located in seven different genetic regions, including the MHC, showed a trend for association to OCB status (p<10 −5 ) ( Table S1 ).

Subgroup analysis of six studies with higher cumulative dose of statin use, defined as statin use over 180 cumulative defined daily doses (cDDDs) or 0.5 years (cumulative duration), showed a trend towards more risk reduction of liver cancer (RR=0.53, 0.36 to 0.79), but with a high degree of heterogeneity (I 2 =90%, p<0.00001; see online supplementary figure S7).