“reached borderline significance”

Although all large HFpEF trials addressing renin-angiotensin-aldosterone system (RAAS) inhibitors failed to reach statistical significance for the primary outcome, many of them reached borderline significance for a primary endpoint or statistical significance for secondary endpoints, subgroups or post-hoc analyses [ 3 – 5 , 7 , 45 , 46 ].

Only the measured exercise capacity was proven as a significant predictor of survival in this cohort treated with palliative intent, whereas the self-reported exercise behaviour just reached borderline significance [ 30 ].

At multivariate analysis (adjusting for the individual factors considered in the model reported in Table 1 ), history of blue-collar work reached borderline significance as a predictor of surgically treated CTS (OR, 4.2; 95% CI, 1.0-17.5).

After adjustment for multiple testing, the difference was statistically significant on Earth but only reached borderline significance in space, Table 2 .

However, the analysis only reached borderline significance after FDR correction (pFDR = 0.063).

A subgroup analysis of seizure recurrence in patients with a calcified lesion reached borderline significance with a pooled CIR of 1.79 CI: (1.00; 3.20) thus favoring 24 months treatment versus 6 months treatment in this particular subgroup ( Fig 7 ).

Similarly, we found no association between the SLC30A8 rs13266634 variant and type 2 diabetes, while an association with combined IFG/type 2 diabetes reached borderline significance.

In the analysis of genetic susceptibility to CRS of any grade, the distribution of PRS for monocyte count (p=0.063), white blood cell count (p=0.081), interleukin (IL)-6RA levels (p=0.080), and IL-8 levels (p=0.099) reached borderline significance in those who experienced CRS as compared with those who did not.

Operative duration using the robotic platform was significantly longer versus laparoscopy, which is consistent with existing published studies although this only reached borderline significance within the colorectal cancer subgroup [ 28 , 54 ].

This reached borderline significance from age 75 onwards, with heterozygotes displaying a 32% lower risk of incident AD dementia compared to homozygotes for the major allele (HR = 0.68, 95% CI [0.47, 1.00], p = 0.049, n = 551, incident cases = 35).

26 ± 5.0 days, P = 0.079), a difference that reached borderline significance.

The interaction term between serum alpha-Klotho and TyG index reached borderline significance, supporting a postulate of potential synergistic effect of serum alpha-Klotho and TyG index on the risk of CVD. 3.4.

Our analysis indicated a trend toward more asymmetric divisions in irradiated organoids, which reached borderline significance for those irradiated with 0.5 Gy ( Figures 4 H and 4I).

Our study confirms the findings in the latter study, as high uPAR expression only for the sub-group of well differentiated tumors was associated negatively with OS in the univariate analysis and reached borderline significance in the multivariate analysis.

Importantly, the primary endpoint reached borderline significance, while the study was powered for a 10-year follow-up [ 28 ].

In the luteal phase the levels reached borderline significance with a p-value of 0.07 but no changes were seen after tamoxifen therapy, Figure 2 . miRNA-193b, -203, -451, and -452 were unaltered in breast cancers but in normal breast tissue miRNA-193b and miRNA-203 exhibited significantly decreased levels in postmenopausal breast tissue and increased levels in the luteal phase of the menstrual cycle suggesting that hormone exposure may affect their levels, Figure 3 .

IN contrast, the differences in the TOJV threshold between these two groups reached borderline significance between these two groups.

Wearing reading glasses correlated significantly with high MMSE-blind after adjustment for sex and age (OR = 2.14, 95% CI = 1.16–3.97, P = 0.016), but reached borderline significance after adjustment for education.

At the level of species within orders, however, we found a negative relationship that reached borderline significance: species from smaller orders tended to have a higher mean research effort than species from larger orders (Spearman rho between the number of species per order and the average number of publications per species within each order = −0.354, p = 0.055, Figure 2b ).

In EASs, while the inverse association between CAD and MDD reached borderline significance in the primary IVW analysis, neither MR‐Egger nor weighted median methods produced significant estimates, and confidence intervals were wide.

The median percentage of Ki-67+CD4+ T cells in chronic progressive patients was significantly higher than in chronic stable patients at baseline and second follow-up, and reached borderline significance at first follow-up.

Between-arm differences in weight and BMI over the study period reached borderline significance.

In our cohort, past users of indinavir had a higher risk of GFR decline that reached borderline significance (PR = 1.7; 95% CI: 1.0–2.8).

Remarkably, the meta-analysis showed that the association between IL-10 and NAFLD reached borderline significance.

Global budgeting did not significantly impact overall utilization of reconstructive procedures amongst Medicaid beneficiaries, though there was an increase in utilization of emergent/urgent reconstructive procedures that reached borderline significance (0.03% per quarter; 95% CI, 0.0%–0.05%).