“nominally significant”

ARHGEF18 showed a nominally significant downregulation (i.e., higher Ct values) in cases ( p = 0.037), and SRXN1 showed a trend towards downregulation in cases ( p = 0.056) compared with the combined control group.

Of ten transcripts, only HAND2 showed a nominally significant reduction in APL+ women (median ΔCt −2.04 vs. −1.30; p = 0.037; rank-biserial r = −0.47); this signal did not survive Benjamini–Hochberg correction (q = 0.372).

The combined haplotype GGT, consisting of all three risk alleles, was associated with PEX (p=0.037, nominally significant), conferring a 1.8-fold of increased risk of the disease (OR=1.8, 95% CI=1.03–3.28; Table 3 ).

Perhaps in line with this idea, we did see a nominally significant benefit of vitamin D on biological age ( p = 0.037) before correcting for multiple testing.

The linear effect for Existence was nominally significant, b = −0.107, p = .037, but was not significant after FDR correction, p FDR = .130.

A nominally significant association with bleeding risk persisted only for rosuvastatin (OR = 2.189; 95% CI: 1.039–4.612; p = 0.037), but this finding should be interpreted with caution and regarded as exploratory. 3.4.

Interestingly, two SNPs were also nominally significant (rs929626 with P = 0.037 and rs17543752 with P = 0.05) in the same direction as in the GWAS (Table 1 ) .

In contrast, the probabilities of transitioning from other PL states to PL state 3 were all increased, with the transition from PL state 4 to PL state 3 also showing a nominally significant difference (uncorrected p = 0.0376, Cohen’s d = 0.5201).

While the interaction between BDNF genotype and N-3 PUFA or N-6 PUFA intake did not reach significance (data not shown), the interaction between BDNF genotype and N-3 : N-6 PUFA ratio is nominally significant for hip in men ( P = 0.038), but not in women ( P = 0.458).

Additional four windows (1, 3, 4 and 5) showed nominally significant global p-value with LDL-C confirming the independent effect of APOE 2440/rs769450 (p = 0.038).

PERMANOVA analyses identified nominally significant effects of Age within the ONT dataset at the phylum (R2 = 0.204, p = 0.038), family (R2 = 0.154, p = 0.020), and genus (R2 = 0.139, p = 0.029) levels, whereas no nominally significant effects were detected in the Illumina dataset (Supplementary Table S2).

Sydney MAS was nominally significant (OR = 0.81, p = 0.038) whilst the other replication cohorts did not reach statistical significance but were generally in similar directions to the UKBB results.

Among diabetic patients, a nominally significant difference in unadjusted event rates was observed (12% vs. 35%, p = 0.038), though this exploratory subgroup analysis requires cautious interpretation given the small sample and absence of adjustment for confounders. 4.1.

Additionally, this gene/region was nominally significant ( p = 0.038) in AA suggesting that the gene/region may have a similar effect across ethnicity.

Additional sensitivity analyses showed that the cML-MA-BIC-DP method (OR 0.60, 95% CI 0.53–0.69, p = 3.85 × 10 −11 ) yielded a similar result to IVW and weighted median methods ( Table 5 ), while the association from MR-APSS method was nominally significant (OR 0.20, 95% CI 0.05–0.92, p = 0.038) ( Table 5 ; Supplementary Figure S2 ).

A nominally significant LS mean difference of 30.8 m ( p = 0.038) between reldesemtiv 450 mg bid and placebo was observed up to 4 weeks after dosing at the follow-up visit.

Also in these analyses, lower levels of vitamin B2 showed a nominally significant association with ADHD (β=−0.29, P =0.038), whereas none of the other vitamins (including B6 and B9) was significantly associated with ADHD.

The associations with non-synonymous and the NSD20 variants in the dichotomous group remained nominally significant ( P = 3.8 × 10 −2 and P = 4.4 × 10 −2 , respectively) even after the removal of the R377W and R507H variants previously identified in GeM-HD GWAS (Supplementary Table 3a ).

Results Nominally significant differences in the allele frequencies for the rs1883832 CD40 gene polymorphism between RA patients and controls were found ( p = 0.038).

Although the analysis of the original four-category scale produced a nominally significant result (χ 2 = 8.45; p = 0.038), more than one-third of cells (37.5%) had expected frequencies below 5.

Moreover, the association between infections and TLR4 showed a borderline effect in all patients (p = 0.051) and was nominally significant in the preemptive treatment group (p = 0.038).

When tested individually, both di- and tetranucleotides showed at least nominally significant signals (two-sided z -proportion test P = 0.038 and P = 3.7 × 10 –38 , respectively), but trinucleotides did not ( P = 0.95).

The 30 fasting glucose associated SNPs in Europeans had a nominally significant effect on the risk of schizophrenia (IVW estimate of odds ratio, OR: 0·84, 95% Confidence Interval (CI): 0·71–0·99, p = 0·038; Fig. 1 and Fig.

Additionally, nominally significant negative associations were observed for total WBC count ( p = 0.038), neutrophil count ( p = 0.016), granulocyte count ( p = 0.028), sum neutrophil eosinophil counts ( p = 0.032), sum basophil neutrophil counts ( p = 0.012) ( Supplementary Table S23 ).

MR pleiotropy residual sum and outlier (MR-PRESSO) test identified 5 outliers for IBD, 1 for RA and 2 outliers for vitiligo ( Table S10 ), whereas exclusion resulted in a nominally significant association for vitiligo (OR, 95% CI: 0.827, 0.691–0.989), p -value = 0.038; Figure 4 a).