“nominally significant”

As shown in online supplemental table S4 , the effect allele frequencies in the in-house controls and ORs were generally comparable with those obtained by using the 60KJPN as controls ( online supplemental table S2 ), except that the low frequency allele rs9290877C at LPP showed higher ORs and nominally significant association when the in-house controls were used.

We selected genes and methylation sites that showed nominally significant differences between RES and NRES, at the p-value less than or equal to 0.05 and absolute average beta value difference greater than or equal to 0.025, for gene expression and methylation, respectively.

Although several nominally significant associations were observed, none remained statistically significant after correction for multiple testing. 4.

Bonferroni correction was applied to account for the multiple testing (a total of 28 FAs), where p -value < 0.002 (0.05/28) was regarded as statistically significant and p -value < 0.05 was regarded as nominally significant [ 29 ].

Moreover, when the difference in PTI (healthy side minus affected side) for each plantar region was calculated and compared between the two groups, nominally significant differences were observed for the lateral sole (mean difference: 1.16 N·s/cm2, 95% CI: 0.08 to 2.24, Cohen’s d = 0.958) and entire sole (mean difference: 0.53 N·s/cm2, 95% CI: -0.11 to 1.17, Cohen’s d = 0.718) before correction for multiple comparisons ( P = 0.037 and P = 0.048, respectively; Table 5 ; Fig. 5 ).

The nominally significant predictor for HDL cholesterol in nonaggressive and aggressive participants was the total value of the PANSS scores.

The apparent differences in significance across strata are likely related to sample size and event distribution, and multiple subgroup comparisons may also yield nominally significant findings.

In our cell type-adjusted model, FLT1 and LEP remained only nominally significant whereas ENG did not meet the nominal significance threshold.

Single findings for longevity and EAA were nominally significant in PGS analyses and sign tests.

As EQ-5D score, Borg dyspnoea score and LPH score came after time to clinical worsening (which did not reach statistical significance) in the hierarchy these analyses can only be considered exploratory and nominally significant.

However, caution should be exercised when interpreting these results, since these nominally significant single SNP and haplotype associations would not survive correction for multiple testing.

The rs2247856 showed nominally significant differences in both genotype and allele frequencies in the APOE ε4 non‐carrier group.

Network analyst was used to understand the protein-protein interaction network [PMID: 25,950,236} of all nominally significant genes (p.unadj < 0.05).

After including incident silent MI events, the significant increase in MI was no longer nominally significant.

In the DISCOVERY trial, genotypes of 2 SNP s in the GNAS gene were nominally significant in the prospective screening and significantly associated with VT when viewed as recessive traits in post hoc analyses ( TT vs CC / CT in c.393C>T: HR 1.42 [ CI 1.11‐1.80], P =0.005; TT vs CC / CT in c.2273C>T: HR 1.57 [ CI 1.18‐2.09], P =0.002).

These included a sensitivity analysis for radiographic PFS that showed a nominally significant difference benefiting the combination group.

Of these, 291 probesets (corresponding to 283 unique genes) were nominally significant.

Breathing discomfort There was a reduction in breathing discomfort for tiotropium/olodaterol versus placebo as indicated by nominally significant reductions in both the slope and intensity of breathing discomfort at isotime ( figure 5 ), with similar results seen in the individual studies (supplementary table S3 and supplementary figure S8).

When leveraged correctly, the pedigree structure can help improve statistical power, but both small sample size and small effect size reduce power, such that not only is it more difficult to detect associations, but those associations that are nominally significant have a higher likelihood of being spurious.

In the view that correction was not performed for multiple tests, these two findings would be considered nominally significant.

In women under statin treatment, three of the four SNPs were only nominally significant with F-statistics in between 7 and 10, probably due to the lowest sample size across all subgroups.

Furthermore, some associations that were nominally significant were statistically significant at the FDR level ( Table S2 ).

histolytica/dispar ), however only nominally significant in cohort II.

Single marker analysis Allele and genotype frequency comparisons between APACG patients and controls demonstrated nominally significant differences with p values of 0.024 and 0.028, respectively, for the C/T polymorphism at intron 1 ( rs1157699 ), but this significance was lost after Bonferroni correction (corrected p value 0.144 and 0.168, respectively).

Therefore, the predictive multivariable model included all 12 variables that exhibited a nominally significant association with PD risk within the unadjusted regression analysis, excluding coffee consumption due to its high collinearity with smoking and adding the age at baseline and gender variables as covariates ( Figure 1 and Supplementary Table 8 ).