“nominally significant”

Within module steelblue, nominally significant pathway enrichment was related to ion channel activity, membrane potential homeostasis, and vesicle transport.

Strikingly, this BMI signal colocalizes with 15 BMI MR trans -eQTLs ( PP median = 0.67 [range 0.49–0.98]) and 64 BMI MR trans -aQTLs ( PP median = 0.89 [range 0.49–1.00]), though among these nominally significant, colocalized trans -QTL signals, only 8 trans -aQTLs ( ANG , CSNK2A2 , ID2 , PIM1 , PTPRJ , TENM4 , TNFRSF10C and ZFAT ) were significant at FDR < 0.05 ( Fig 4 , and Tables 1 , S11 – S15 and S17 ).

Both analyses, however, yielded a substantial number of nominally significant genes with differential expression.

With consideration of a second validation tier as being nominally significant and directionally consistent in the other cohort, these proportions amounted to 57% and 88% for AGES-Reykjavik and QMDiab, respectively ( Fig. 1E ).

This study identified nine nominally significant AD risk associations, a higher significance rate than most such studies, with the POU2F1 association also reaching study-wide significance.

The only subgroups that showed a slight, but nominally significant, decrease of seasonality were men who died by drowning and women who used the method of hanging.

To better understand the influence of HLA on high-risk pALL, we start by analyzing these possible higher order interactions by focusing on the nominally significant predisposing and protective alleles identified from the single locus analyses of HLA-A, HLA-B, and DRB1.

In total, none of the reported effects of journal rank, even those nominally significant, indicate a clear, obvious difference between journals.

The candidate gene or genes for other heterogeneity‐sensitive GWAS SNPs were determined according to nominally significant eQTL and/or high‐throughput 3C interactions (Supplementary Figure 8 , http://onlinelibrary.wiley.com/doi/10.1002/art.42129 ).

Although one CpG site was found to be nominally significant, we did not consistently replicate the direction of this association.

A GRS of 10 POAG lead variants identified in European-descent GWAS was only nominally significant in African American prevalent cases.

For sleep midpoint, a nominally significant association was observed with knee osteoarthritis (OR (95% CI) = 0.52 (0.36 to 0.74), P IVW = 0.0004, FDR = 0.018), and hip and/or knee osteoarthritis (OR (95% CI) = 0.65 (0.46 to 0.93), P IVW = 0.017, FDR = 0.248).

There was a nominally significant association between infant sleep duration and average DMN node degree that was not significant after correcting for multiple comparisons ( Fig. 4 B; b = 0.18, SE = 0.07, p = 0.01, q = 0.06).

Evaluation of the Excess Significance We calculated excess significance bias by investigating whether the observed (O) number of nominally significant findings was significantly different from the expected (E) number of statistically significant studies.

Based on the identified nominally significant DEGs, we performed the following post hoc analyses: [(5-Htt+/+SA vs. 5-Htt+/+C) vs.

In contrast, the lipid associations showed nominally significant bicarbonate and highly significant potassium associations.

P values less than 0.007 were considered nominally significant in the analysis of the 7 SNPs.

Conversely, the LPA locus showed only a nominally significant association with baseline LDL-C in Oni-Orisan et al.’s paper 6 but was clearly associated with baseline LDL-C in the IMPROVE-IT dataset.

Due to the larger number of SNPs used in this analysis, the standard error of this intercept is smaller, leading to a nominally significant p -value for directional pleiotropy ( Table S5B ).

We found 1136 CpGs associated to BMI (nominally significant), of which 729 (64.1%) show a significant P -value for CRP mediating the effect of BMI effects on DNA methylation, with 213 loci reaching Bonferroni significance ( Supplementary Data 2 , 10 ).

Additionally, a p-value of less than 0.05 was considered nominally significant for all MR methods.

Effect of genotype on basal gene expression We detected nominally significant genotype-dependent differences in expression of two genes in caudoputamen, one gene in nucleus accumbens, six genes in hypothalamus, and four genes in hippocampus.

In the full cohort, wine was only nominally significant (P β <0.05, P β ≥7.94×10 −4 ).

Significant or nominally significant reduction in symptoms was observed at Weeks 6 and 12 in both trials (Figure E5 [E-RS], Figure E6 [SGRQ]).

For the sliding windows, 2351 tests were conducted and 314 were found to be nominally significant (0.0021–0.05, not accounting for multiple testing).