“nominally significant”

To assess whether the two nominally significant IUGR-group correlations were independent of baseline confounders, exploratory multivariable linear regression models were fitted within the IUGR group with birth weight percentile as the dependent variable and SHBG as the predictor of interest, and with AC percentile as the dependent variable and total testosterone as the predictor of interest; both models were adjusted for maternal age, systolic blood pressure, and sampling time.

For some other variables [ever had a committed relationship, number of sex partners (males)], nominally significant associations (i.e., uncorrected for multiple testing) were found in the expected direction.

However, in the model for PANSS negative symptoms scores, the interaction effect of N1b modulation and diagnosis was significant (albeit at an uncorrected significance threshold), and the positive association between PANSS negative symptoms scores and N1b modulation was nominally significant in SZ spectrum patients.

Of the genes differentially expressed between those in the PTSD and TE groups in the current sample, none overlapped with the nominally significant genes differentially expressed in females exposed to IPT in Breen et al.

A reduced risk of all-cause death in patients with T2D was also noted in EXSCEL (exenatide) (HR [95% CI] 0.86 [0.77–0.97]) and PIONEER-6 (oral semaglutide) (0.51 [0.31–0.84]), although these results were only nominally significant, owing to the hierarchical testing plans used [ 15 , 33 ].

Two genes, S100A8 and TYROBP , had consistent changes in expression in both individual and pooled sequencing datasets and were nominally significant in gene-based association analysis.

Minor alleles were linked to higher BMI in 55% of nominally significant SNPs.

But on the level of the cis -effects on the expression of the gene mRNA, the intronic non-coding editing events have less nominally significant effects compared to those events located in the 5′UTR, exons and 3′UTR (Fig. 4a–c , right) where the general patterns of the effect directions were positive rather than negative, indicating that the presence of the non-coding RNA editing events at 5′UTR, exons and 3′UTR were more likely to increase the mRNA expression of the genes.

In the heterogeneity test, we selected loci such that the results of the association study were nominally significant in at least one of the sex groups.

Consequently, the nominally significant subgroup findings should not be generalized; they require rigorous independent confirmation in larger, well-defined groups.

We thus present all nominally significant categories ( Table S6 ), which are highly consistent with previous studies [ 57 ].

For comparison, we did not observe a nominally significant cis effect between TF eSNP and its source gene more than expected by chance (3 out of the 66 TF sources in this dataset).

As detailed in the Methods section, some preselection of genes is done, but the selection does not require even nominally significant association with a survival endpoint, as is often required in survival studies with high-dimensional covariates. 4 , 7 , 34 This allows for the identification of many important genes, some previously known to be involved in cancers other than ovarian, which would not otherwise have been considered.

Among them only age at diagnosis, time from diagnosis to initiation of levodopa treatment, and DRD3 rs6280 were previously identified as significant or nominally significant predictors by univariate analysis.

Next, nominally significant eQTLs from these associations were subjected to shrinkage-based selection using LASSO 151 .

The SNPs showing the largest allele frequency differences between low and high ability groups were further genotyped and tested in an additional sample of 4,258 children, with 10 SNPs finally showing nominally significant association with continuous variation in reading ability (Meaburn et al. 2008 ).

Gender-related differences Despite lack of FDR significant differences in metabolites associated with endurance in males versus females, differences in a number of metabolites were nominally significant, including a number of gamma-glutamyl amino acids and steroid metabolites among others.

These downstream analyses were based on nominally significant results, and permutation‐based validation was not feasible due to limitations of the STRING tool, which restricts large‐scale automated querying.

IMP appeared to partially mediate the associations of the most identified genera with diabetes (mediated proportion ranges from 7.5 to 22.3%), though some of mediated effects were nominally significant (Fig. 5 A).

In a small pilot dataset with sparse repeated measurements and no correction for multiple testing, isolated nominally significant p -values following a non-significant global interaction test are highly vulnerable to random variation and carry no inferential weight.

Interactions were assessed, and although a couple of them were nominally significant due to the power of this large study, they were deemed to be of minimal clinical importance.

Overall, the mean (SD) was 0.7 (0.8) for the CDR‐sb, 1.3 (1.8) for the FAQ, and 27.8 (2.1) for the Mini‐Mental State Examination (MMSE) with nominally significant but very small differences between those who developed incident dementia and those who did not.

In addition, the revised early (<48 h) versus late (≥48 h) subgroup analysis involved multiple unadjusted comparisons across several parameters; therefore, the nominally significant findings observed for selected variables should be interpreted cautiously and considered hypothesis-generating.

Five nominally significant associations were found between the NSCLC and CNVs.

8 Prespecified secondary end point results showed a nominally significant 62% decrease in COVID-19–related medical visits per day across all patients, relative to placebo in a subgroup analysis. 9 However, questions still remain about the clinical relevance of these results for the treatment of contemporary patients in the real-world setting, given that the EPIC-HR trial was conducted in unvaccinated adults without a history of prior infection during a period when the Delta variant was the predominant one.