“nominally significant”

These found that associations with the fornix were attenuated, leading to a null association in the left fornix and a nominally significant association in the right fornix.

Nominally significant differences in fatty acid profiles between the raised and low SDQ score groups were found in omega-3 fatty acids, i.e., n -3 FAs ( Fig. 3 , Table C.6A-C ).

Out of 34 SNPs tested (see Table 2 ), we identified 14 SNPs that showed nominally significant associations with HDL or LDL levels at a p-value of 0.05, corresponding to a FDR of 0.11 when corrected for multiple testing.

Subsequently, binomial tests were performed in R using the function ‘binom.test’, contrasting for each gene the number of nominally significant CpG-sites to the total number of probes annotated to each gene transcript not taking the direction of the methylation change into account.

3.2 Enrichment analyses Within our respective sets of 1,720 and 1,739 putative mosaic mutations, we found enrichment for mosaics that are within 101–500, 501–1,000, 1,001–5,000, and 5,001–10,000 bp from each other (all nominally significant; see Supporting Information Table S4 ).

However, when we focused on probes that showed a nominally significant p-value in the DMP analysis of all samples, we confirmed our previous findings[ 16 ] that CD8 + T cells of MS patients display a higher degree of DNA methylation as compared to healthy controls ( Fig 1 ).

Interestingly, the 'one-carbon pool by folate' pathway, which contains the MTHFR and MTHFD1L genes, was nominally significant for bipolar disorder, showed a trend for major depressive disorder and was not significant for schizophrenia, suggesting that this pathway has distinct effect on mood disorders, probably through a common intermediate phenotype, such as ruminative response style.

For lumbar spine BMD, the causal association with all OA was less pronounced and only nominally significant.

These SNPs were all nominally significant in each of our three independent replication cohorts.

We have therefore reported both results with nominally significant p values, as well as those that do not reach statistical significance but which may be of interest in the context of other data presented here or elsewhere.

With regard to the other candidate SNPs, the ZC3H11B rs4373767 (allele C; β = –0.053, P = 0.030) showed a nominally significant association with AL, but it could not withstand the Bonferroni correction.

The Kolmogorov–Smirnov (KS) test (Table 1 ) revealed a nominally significant discrepancy in the distributions of exome-positive versus exome-negative cases of South Asian and Native American ancestries (reduced diagnostic yield associated with South Asian genetic ancestry, increased diagnostic yield associated with Native American genetic ancestry), however neither of these was significant after adjustment for multiple testing.

All nominally significant results are shown in Table 1 .

As X2K requires differentially expressed genes as input, all upregulated proteins with a nominally significant p value were included in the X2K analysis of each cell line.

An adjusted P -value <.00025 (0.05/200, 200 denotes the number of independent hypotheses) after Bonferroni multiple testing correction was considered as statistically significant, meanwhile P -value between .00025 and 0.05 was considered as nominally significant.

We defined a SNP as having a pleiotropic effect on two phenotypes when the P value for the O’Brien test statistic from the joint model of association of two phenotypes ( P joint ) with the SNP is at least one order of magnitude more significant than the P values ( P univariate ) for both phenotypes and the univariate P values are at least nominally significant ( P univariate < 0.05).

At p = 0.05, eight SNPs presented with nominally significant evidence of association (EOA), although no significantly different genotype distributions remained between cases and controls after Bonferroni correction.

Furthermore, we specifically examined the 91 signature genes significantly associated with iPSCORE iPSC cardiac-fate outcome and found eight with nominally significant expression differences in the same direction (e.g., overexpressed or downregulated) in the two sets of iPSCs ( Figure 5 G), which is 2.5 times more than random expectation (p = 0.012, Fisher's exact test; Figure 5 H).

Of the 39 genes, 22 in EA and 19 in AA had nominally significant interactions with at least one childhood socioeconomic measure on memory performance and/or decline; however, only one, SLC24A4 x father’s education, remained significant after multiple testing correction (false discovery rate [FDR] < .05).

EX enatide S tudy of C ardiovascular E vent L owering Trial (EXSCEL) showed nominally significant reduction in ACM (but not for CV death) [ 3 ]; for ACM these studies appear to suggest that exenatide may be associated with mortality postponement in a broad population and certainly does not appear to increase morality risk.

However, this strategy may increase the risk of false positives; therefore, nominally significant findings should be interpreted with caution and validated in independent cohorts.

Of the 32 variants included in the genetic score, 4 ( FTO , GNPDA2 , NEGR1 , and SEC16B ) showed nominally significant interactions with total fried-food consumption on BMI ( P for interaction <0.05) and all interactions were in the same direction (that is, stronger association between fried-food consumption and BMI in carriers of one or more BMI increasing alleles).

We identified 19 (significant after multiple testing adjustment) and 25 (nominally significant) highest‐ranking proteins associated with joint and chronic back pain, respectively.

Results The short (s) low expressing allele showed association with increased risk of depression related phenotypes, but all nominally significant effects would turn to non-significant after correction for multiple testing in the traditional analysis.

Accelerated biological ageing is not associated with cross-section and longitudinal measures of cognition In the cognitively unimpaired Aβ + cohort, a nominally significant association between cross-sectional PACC scores and accelerated ageing was observed with the Phenoage clock (Supplementary Table 1 , Additional File 1 ).