“nominally significant”

Among these polymorphisms, 11 KIAA0319 variations were genotyped in the present study, and nominally significant associations were detected between 4 SNPs (rs1091031, rs9366577, rs16889556 and rs3756821) and dyslexia.

From the 49 CpGs covered by the HAM-TBS approach, nine CpGs showed nominally significant differential DNAm at baseline, but none of them survived FDR correction for multiple testing (see Supplementary Table B3 ).

Including rs4149313, there were 4 SNPs associated with MI at a nominally significant level (<0.05): rs4149313 (HR 1.36, P-value 0.004), rs2575879 (HR 1.19, P-value 0.014), rs2740487 (HR 1.16, P-value 0.034), rs10820743 (HR 0.85, P-value 0.045).

In addition, this study supports a nominally significant role of the miR-137 variant in amygdala activation during implicit processing of facial emotions, and not the genetic underpinnings of explicit processing, which includes decision-making in response to emotion recognition.

Two other neuroimaging phenotypes showed nominally significant effects on depression, including higher MD in the ATR for MR-Egger (tMD-ATR; β = 0.107, p for MR-Egger = 0.028, p FDR = 0.166; however, the Egger intercept was not significant, p FDR = 0.432, Supplementary Fig. 11 , Supplementary Data 6 and Supplementary Table 3 ) and ICVF in SLF (tICVF-SLF; β = −0.025, p = 0.030, p FDR = 0.179 for IVW).

We also observed a nominally significant 67% reduced risk for cancer in families with CP compared with controls for SNP rs11117758 after Bonferroni correction ( Table 3 ).

Although only nominally significant in this study, the result and the effect of the rs6265 Val66Met polymorphism was shown to be consistent with our previous findings [ 28 ].

We filtered genes that did not exhibit cis-genetic regulation at current samples sizes by keeping only genes with nominally significant estimates of cis-SNP heritability.

Sex‐stratified analysis revealed an altered profile in males, where carriers exhibited a nominally significant increase in their fat‐to‐lean mass ratio, with adipose tissue distribution skewed towards subcutaneous rather than visceral accumulation.

Functional categorization of significant proteins The 15 nominally significant BMI-associated EpiScores were grouped into functional categories based on STRING and UniProt annotations [ 33 ].

Nominally significant interaction was observed with respect to the cardiovascular death or hospitalized HF outcome for several subgroups, including patients with higher versus lower body mass index, lower versus higher baseline glycohemoglobin, with versus without background use of diuretic therapy, and with versus without background metformin use (all P interaction >0.02; Figure 3 ).

Thus, P<2.26×10-4 (2.26×10-4 = 0.05/ (138+83); The number 138 indicates the total count of cases with or without global weighted SA/TH of cortical structure, while 83 represents the total volume of cortical structure) was regarded as significant, whereas P < 0.05 was considered nominally significant and suggestive. 2.4 Ethics As a meta-analysis of previously published GWAS results involving no new human subjects research, this study did not require separate ethical clearance. 3 Results Ultimately, 15 SNPs associated with presbycusis were retained for MR analysis.

SRT found 3 nominally significant pathways using tier one criterion, but none passed the multiple testing correction using tier two criterion (Table 3 ).

All loci except for 17q22 showed nominally significant co-associations for up to six cytokines. p -value–based hierarchical clustering showed grouping of cytokines across all 14 loci whereas each locus seemed to affect mainly one cytokine. 3.2.

When we examined below the top 25 associations on our list of nominally significant GEE results for various SCA phenotypes, there were significant associations with multivariable-adjusted CAC for several SNPs on chromosome 9, including three SNPs (rs10511701, rs1556516 and rs1537371; p-values for association 1.1 × 10 -4 , 8.8 × 10 -5 , and 1.7 × 10 -4 , respectively) lying within a 15 kB region implicated in recent GWAS's for coronary heart disease.

However, we recently conducted an exploratory, untargeted metabolomics study in serum collected from BWPS participants that suggested a potential role for bile acids (BAs): we identified nominally significant associations between BAs and ( 1 ) BMI and TBF (inverse relationship) and ( 2 ) AD (positive relationship) ( 9 ).

However, MR analysis outcomes with an FDR greater than 0.05 but IVW method p-value less than 0.05 were considered to have a nominally significant causal relationship and were identified as potential risk factors.

Consequently, to identify potential biological trends for hypothesis generation, an exploratory screen was conducted based on an unadjusted p < 0.05, yielding 425 nominally significant candidates.

In the sex-specific analysis, the negative associations were only nominally significant in males (OR 0.88, 95% CI: 0.77–0.99) but not in females (OR 0.92, 95% CI: 0.80–1.05), although the sex difference was not statistically significant ( P sex difference 0.642) (Figure 3 ).

LLDAS attainment increased across the 52-week period, and nominally significant differences in LLDAS attainment among patients who were BICLA responders at week 52 were evident from week 12 onwards ( online supplemental table S2 ).

To overcome this challenge, we boosted the PerioLT genetic signal with cross-trait MTAG meta-analysis, thereby identifying 21 genome-wide significant associations for PerioLT (after clumping), among which one was also nominally significant in the original GWAS and colocalized with the genetic signal for T2D (rs17522122).

The Correlation between Figural Intelligence and Basal Ganglia Volume is Influenced by Sex and Intelligence Factor Measurements of our exploratory analysis revealed a nominally significant association between the volumes of the caudate nucleus, putamen and pallidum and figural intelligence scores.

Interestingly, comparisons between BPD patients with and without ELA identified changes in cg10888111 methylation within the gene PXDN that were, although only nominally significant in the EWAS performed in the discovery cohort, significant when validated with a targeted EpiTYPER assay in the same cohort [ 18 ].

We first derived the proportion of interaction effect nominally significant at type I error rate (alpha) threshold of 0.05 among bins of SNPs grouped based on their marginal association (i.e., we derive the proportion of SNPs with interaction p value below 0.05 and p value for marginal effect in bins [1, 0.1], [0.1, 0.01], [0.01, 0.001], etc).

Nominally significant associations were found for rare functional variants in BBS1 , BBS9 , GNAS , MKKS , CLOCK and ANGPTL6 .