“nominally significant”

We found nominally significant differential methylation in IL2, IGFBP6 , and SATB2 between HIV-infected and uninfected groups.

For the known loci GxG search, the Phase II p-value between rs10795668 and rs367615 is 0.01, which is nominally significant at the 0.05 level but does not pass the Bonferroni threshold (0.05/12).

Despite nominally significant higher levels of creatine kinase-MB and myoglobin in patients receiving systemic steroids, adjustment for systemic steroid use in the multivariate analyses had minimal impact on the correlations (data not shown).

Additional taxa showed nominally significant p -values but borderline FDR values, suggesting possible taxon-level differences.

In addition to these associations that remained significant after false discovery rate correction, we detected nominally significant associations with other clinicopathological features ( Table 2 ).

Subsequently, binomial tests were performed in R using the function ‘binom.test’, contrasting the number of nominally significant CpG-sites to the total number (n = 16) of investigated probes annotated as BDNF exhibiting methylation alterations in the same direction.

Functional relationships among these nominally significant proteins were analyzed using the STRING database (version 12.0).

10 Variants in TERT and MAML2 were nominally significant in the meta-analysis; both regions were previously shown to be associated with risk of IDH wt and IDH mut glioma, respectively ( Supplementary Table S1 ).

First, the length of the intervention was only 12 weeks and a longer duration may be more informative and enhance nominally significant associations in light of our modest caloric intervention.

Note that most of the detected peaks were only nominally significant and should be considered as suggestive.

A nominally significant interaction was observed between the IGF2BP2 variant and prenatal exposure to famine on glucose levels during oral glucose tolerance test (OGTT).

The C allele of rs3758987 in HTR3B gave a nominally significant association with OD.

Out of all plasma protein PGSs in the replication cohort, only CX3CL1 had a nominally significant association with LOAD diagnosis (OR: 0.842, 95%CI: 0.719–0.949, p -value: 0.0019).

Among all loci, the effect sizes of six variants ( IRX4/IRX2 , INTS10/LPL , MLC1 , ADAMTS9-AS2 , PDE3B and CASC8 ) were nominally significant different between men and women in AA ( P het < 0.05) ( S6 Table ).

Other nominally significant associations were observed for gender—with women showing a 39 (5–82)% higher risk of LID—and AAO, with 2 (0.3–3)% decrease of risk for each year increase of PD onset.

In a reverse MR analysis, we identified a nominally significant bidirectional causal relationship between colorectal cancer and one gut microbiota species, Syntrophorhabdia , at the threshold of P IVW < 0.05 [OR (95% CI) 1.011 (1.000–1.023), P = 0.046], as reported in Table S3 .

Statistical analyses A hierarchical gating approach was employed for statistical analyses, whereby antibodies and proteins of interest for downstream analyses were first identified with discovery analyses in MYHAT using both nominally significant and FDR-corrected p values of 0.05; here, FDR corrections were applied per antibody titer.

However, these relationships were principally driven by BMI as most became non-significant after correcting for BMI barring female hip circumference and male fasting insulin which remained nominally significant ( Table 1 B).

Additionally, we detected several nominally significant associations in our overall cohort of C9ORF72 expansion carriers, which did not remain significant after adjustment for multiple testing (Table 3 ), including associations with specific C9ORF72 transcripts (e.g., variant 1 and variant 3).

The correlation between activity and dominance score is nominally significant based on Z score ≥ 1.96 ( r I = –0.410 (0.104)).

Genes with P-values above this threshold but below 0.05 were classified as nominally significant causal associations.

We found a nominally significant positive correlation between minutes non-REM sleep and recall of neutral pictures ( r = 0.483, p uncorrected ≥ 0.031).

Results: Nominally significant associations between genetic variants and cytokine levels were identified.

When a dose-response meta-analysis was conducted among 13 prospective studies [ 31 ], the association per one cup of coffee per day was nominally significant (OR for postmenopausal disease = 0.97, 95% CI = 0.95–1.00), which was consistent with the finding of the current MR study (OR = 0.90, 95% CI 0.79–1.02).

After this adjustment, the relationships between the FIQ and the LESS-II total score (r = 0.316, p = 0.003), and between the FIQ and the UD subscale (r = 0.326, p = 0.002), remained statistically significant; other relationships were nominally significant but did not meet the adjusted threshold ( Table 5 ).