“nominally significant”

Variants that were nominally significant ( P < 0.05) and within 1000 kb and a r 2 > 0.1 of the sentinel SNPs were assigned to a locus.

Five of the 19 SNPs demonstrated a nominally significant association with neovascular AMD (P < 0.05), of which two (rs3173798 and rs3211883) withstood Bonferroni correction for multiple testing (rs3173798, nominal P = 9.96 × 10−4, allele-specific odds ratio = 0.55; rs3211883, nominal P = 2.09 × 10−4, allele-specific odds ratio = 0.50).

Genetic pathway analysis We identified a gene set by selecting all genes showing nominally significant expression changes ( P ≤ 0.05) in our data set, and we tested if our gene set was enriched for associative signal with two phenotypes: (i) hippocampal volume in adults; (ii) antidepressant response.

Most (n=107, 74%) of these effects were nominally significant at P<0.05, and 76 showed an increased risk.

We identified nominally significant ( p -value ≤ 0.05) alteration after doxorubicin treatment in 127 metabolites measured on the HD4 platform.

Overall, 30 of the 48 (63%) associations reported a nominally significant summary result at p<0.05 (19 had p≤0.001).

Under the assumption that the gap statistic follows a standard normal distribution, approximate p-values for all three analyses were nominally significant (p < 0.05), with the blood and dura analysis resulting in the most significant gap statistics (p < 1×10 -10 ).

CSF Markers and Clinical Variables Bivariate correlation analyses revealed a significant relationship between semantic fluency and α‐synuclein that withstood correction for multiple testing ( r = −0.53, P = 0.003) as well as nominally significant associations ( P < 0.05) between semantic fluency and IL‐6, ACE‐R and IL‐6, and age and both IFN‐γ and IL‐1β (Table S2 ).

We report nominally significant associations at the P ≤ 0.05 level.

Overall, nine of the 11 of the outcomes reported nominally significant summary results ( p < 0.05), with 4 associations surviving the application of the more stringent p value ( p < 10 −6 ).

In multivariate analysis, patients homozygous for the CRC risk allele of rs7013278 or rs7014346 (both at 8 q24) were only nominally significant for poorer overall survival compared to patients homozygous for the protective allele (hazard ratio = 2.20 and 1.96, respectively; P <0.05).

No significant PRS-by-environment interactions were observed after accounting for multiple comparisons, but alcohol consumption and physical activity had nominally significant interaction terms with PRS ( p -value < 0.05). 4.

Under conservative Bonferroni correction (α = 0.0033), the NLR–dyspnea ( p = 0.001) and MUST–appetite loss ( p = 0.001) associations remained statistically significant; the NLR–physical functioning, NLR–role functioning, and MUST–nausea/vomiting associations were nominally significant ( p < 0.05) but did not survive Bonferroni correction and are reported as exploratory.

A signal was considered to replicate if: i) it met our Bonferroni corrected gene-level significance threshold ( p <1.32x10 -7 ); ii) >2 variants were tested; iii) it was nominally significant ( p <0.05) in the unadjusted test for WGS (i.e. without adjusting for correlated traits).

For associations without this information reported in the umbrella reviews, we recorded the information necessary to make the appropriate calculations and classifications: total number of cases, largest study reporting a nominally significant result (P<0.05), 95% prediction intervals, I 2 value, Egger regression asymmetry test, and evidence of excess significance.

While no effect differences were significant at Bonferroni-corrected p -value thresholds, we observed 35, 31, and 8 nominally significant ( p < 0.05) effect differences for Blacks compared to Whites for hospitalization ( Figure S4 ), ICU/admission ( Figure S5 ), and death ( Figure S6 ), respectively.

The chemokine MCP3 showed a nominally significant association with ischemic stroke risk (OR: 0.93, 95% CI: 0.88–0.99, unadjusted p < 0.05).

In addition, we identified 61 genes that were nominally significant association ( P < 0.05) with both tau and amyloid deposition including APOE , TOMM40 , and COL5A2 ( P < 0.005) with both tau and amyloid pathologies (Supplementary Fig. 4 and Supplementary Table 13 ).

Nominally significant correlations between OBP and 24-h ABPM were also reported by five studies (all comparisons, r = 0.46–0.69, P < 0.05 to P < 0.001) [ 19 , 24 , 29 , 41 , 45 ].

A small proportion of associations and interactions with sex were nominally significant at P < 0.05 but not the more conservative 0.001 threshold; these may reflect a degree of type-1 error.

To prioritize findings with the greatest evidence of robustness, proteins were considered candidate causal factors if they met two simultaneous criteria: (1) a nominally significant IVW p-value (p < 0.05), and (2) directional consistency of effect estimates across all four MR methods.

These pathways are potential novel associations with the Target Disease, which we checked by measuring enrichment of nominally significant SNPs (p < 0.05) in those genes from among the Target GWAS.

Results: In study 1, four SNPs showed nominally significant association ( P ≤0.05) with OS; two of these SNPs (rs1126647, rs4073) in IL8 were associated ( P ≤0.05) with OS in study 2.

This showed that 16 of the 28 gene groups showed evidence of similarity; 12 for growth, 10 for HPO (6 overlap with growth) significant at p < 0.05 after Benjamini Hochberg correction, and 1 for development nominally significant at p < 0.05 (overlaps growth and HPO).

We defined this set as cis -eQTLs identified in LCLs or transformed fibroblasts in GTEx ( FDR < 0.05), which were not even nominally significant ( P > 0.05) in GTEx breast tissue.