Cancer expression quantitative trait loci (eQTLs) can be determined from heterogeneous tumor gene expression data by modeling variation in tumor purity.

Genome Biol · 2018 · PMC6131897 · PMID 30205839

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0740

boldest claim

The sentences

nominally significantP > 0.05actually significant

We defined this set as cis -eQTLs identified in LCLs or transformed fibroblasts in GTEx ( FDR < 0.05), which were not even nominally significant ( P > 0.05) in GTEx breast tissue.

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borderline significantP < 7.4 × 10 − 2so close (0.05 < p ≤ 0.1)

Interestingly, 8 of the 9 eQTLs for these GWAS variants, which could be confidently attributed to breast cancer cells, were also at least borderline significant in normal breast tissue in GTEx (1.3 × 10 − 20 < P < 7.4 × 10 − 2 ; Additional file 3 : Figure S8; Additional file 1 : Table S8), suggesting that the effect of genetic variation on gene expression in the baseline normal tissue state is generally maintained following tumorigenesis.

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