“nominally significant”

While none of the GO terms from the trio univariate GSEA met the FDR significance threshold, nominally significant (p < 0.05) pathways suggest some overlap with Cohort 1 results, including neuron recognition , cerebral cortex cell migration and axonal fasciculation and GO terms related to.

Overall, 30 of the 48 (63%) associations reported a nominally significant summary result at p<0.05 (19 had p≤0.001).

A nominally significant association was observed between survival and the DPP4 enzymatic activity at day 1 (p ≤ 0.05), with a higher DPP4 enzymatic activity being associated with an increase in survival.

Variants that were nominally significant ( P < 0.05) and within 1000 kb and a r 2 > 0.1 of the sentinel SNPs were assigned to a locus.

The chemokine MCP3 showed a nominally significant association with ischemic stroke risk (OR: 0.93, 95% CI: 0.88–0.99, unadjusted p < 0.05).

Five of the 19 SNPs demonstrated a nominally significant association with neovascular AMD (P < 0.05), of which two (rs3173798 and rs3211883) withstood Bonferroni correction for multiple testing (rs3173798, nominal P = 9.96 × 10−4, allele-specific odds ratio = 0.55; rs3211883, nominal P = 2.09 × 10−4, allele-specific odds ratio = 0.50).

Overlap between Life-History Traits Nominally significant genes ( P < 0.05) showing association between root-to-tip ω and each of the life-history traits under study (MLS, female maturity, gestation length, weaning time, and body mass) were retrieved and investigated for overlap.

In unadjusted analyses, 26 SNPs from nine loci were associated with TC, 22 SNPs from 10 loci with LDL, 58 SNPs from 13 loci with HDL, and 40 SNPs from 14 loci with logTG at the nominally significant level ( P < 0.05).

Most (n=107, 74%) of these effects were nominally significant at P<0.05, and 76 showed an increased risk.

Nominally significant positive correlations (p < 0.05) were observed in kidney, liver, lung and muscle (Supplementary Fig. 6D-G).

Although the CT measures of hepatic fat based on liver attenuation cannot be directly converted to units of liver fat percentage, 7 of 8 variants’ associations were directionally consistent, and 5 were nominally significant (p < 0.05; Table S7 ).

However, 12 out of 245 CpG sites showed nominally significant differences ( p < .05) between pre‐ and post‐menopausal women.

We identified nominally significant ( p -value ≤ 0.05) alteration after doxorubicin treatment in 127 metabolites measured on the HD4 platform.

Polygenic scores for behavioural traits None of the associations between PGSs for behavioural traits and SUD-related phenotypes surpassed multiple testing corrections, however, nominally significant associations ( p < 0.05) are detailed bellow.

For associations without this information reported in the umbrella reviews, we recorded the information necessary to make the appropriate calculations and classifications: total number of cases, largest study reporting a nominally significant result (P<0.05), 95% prediction intervals, I 2 value, Egger regression asymmetry test, and evidence of excess significance.

CSF Markers and Clinical Variables Bivariate correlation analyses revealed a significant relationship between semantic fluency and α‐synuclein that withstood correction for multiple testing ( r = −0.53, P = 0.003) as well as nominally significant associations ( P < 0.05) between semantic fluency and IL‐6, ACE‐R and IL‐6, and age and both IFN‐γ and IL‐1β (Table S2 ).

A signal was considered to replicate if: i) it met our Bonferroni corrected gene-level significance threshold ( p <1.32x10 -7 ); ii) >2 variants were tested; iii) it was nominally significant ( p <0.05) in the unadjusted test for WGS (i.e. without adjusting for correlated traits).

Results: In study 1, four SNPs showed nominally significant association ( P ≤0.05) with OS; two of these SNPs (rs1126647, rs4073) in IL8 were associated ( P ≤0.05) with OS in study 2.

Nominally significant correlations between OBP and 24-h ABPM were also reported by five studies (all comparisons, r = 0.46–0.69, P < 0.05 to P < 0.001) [ 19 , 24 , 29 , 41 , 45 ].

A previous ANOVA study of the four SNPs with the phenotypes FN-sBMD, LS-sBMD, HC, WC, and BMI (not shown) all showed either a clear trend ( p < 0.1) or nominally significant association ( p < 0.05) with BMD, while the SNP of the MEF2C gene was significantly associated with BMI, WC, and HC.

Overall, nine of the 11 of the outcomes reported nominally significant summary results ( p < 0.05), with 4 associations surviving the application of the more stringent p value ( p < 10 −6 ).

A small proportion of associations and interactions with sex were nominally significant at P < 0.05 but not the more conservative 0.001 threshold; these may reflect a degree of type-1 error.

No significant group differences in BMI trajectories during the pandemic were observed (F(2,392) = 0.43; P = 0.65, η p 2 = 0.002); a nominally significant increase in BMI was observed in the participants at low risk for eating disorder (pre-PD < LD2, P < 0.05) but not in those with higher eating disorder risk ( Fig. 5(d) ).

S4 Table Gene set enrichment results based on nominally significant TWAS genes (P<0.05).

In multivariate analysis, patients homozygous for the CRC risk allele of rs7013278 or rs7014346 (both at 8 q24) were only nominally significant for poorer overall survival compared to patients homozygous for the protective allele (hazard ratio = 2.20 and 1.96, respectively; P <0.05).