“modestly significant”

For instance, a negative correlation of −0.1 may be only modestly significant in one cancer type but highly significant in another cancer type due to different sample sizes, which may to some extent even mislead one to think that the identified interactions were cancer-specific when it in fact ubiquitously occurs among many other cancers.

Suggestive evidence for interaction of smoking with SNPs at other loci also showed modestly significant opposite association directions in stratified GWAS among smokers and non‐smokers (Table 2 ).

When we examined for associations between SCA and SNPs on the 100K chip that reside in or near some previously studied candidate genes, we confirmed a number of modestly significant SNP associations with SCA phenotypes (Table 4 ).

While the remaining pairwise tests all failed to demonstrate a significant slope or intercept when not constrained through the origin, each did exhibit at least a modestly significant positive slope when constrained through the origin, suggesting some degree of pleiotropy or causality between each trait ( Fig. 4 ).

Due to the large number of markers evaluated in a genome-wide scan, signals with small effects and modestly significant P -values are likely to be dismissed after the correction of multiple testing.

Only modestly significant differences for just three of the implemented deleteriousness metrics (M-CAP, fathmm-mkl and MutTaster) were observed comparing all IBD against controls in this relatively small sample.

The group consisting of swd1 Δ , swd2 Δ , swd3 Δ, set1F H3K4me− , and H3K4R mutants included smaller subsets of differentially expressed probes ( Figure 1C , upper panel), with modestly significant GO enrichment for upregulated transcripts related to stress response and carbohydrate metabolism ( Figure 1—source data 1A ).

Additionally, both the soil C pool and plant C accumulation also emerged as modestly significant predictors of yield performance ( Figure 7 ). 3.

The associations between the CHA2DS2-VASc score and 30-day mortality for CCU patients with different comorbidities and parameters were revealed in subgroup analyzes. After PSM, the interactions between subgroup factors and the HR for 30-day mortality were modestly significant, except for WBC.

The Rotterdam study 25 constructed a second risk score based on 169 SNPs including the original 53 modelled in our study, as well as a further 116 for whom only modestly significant changes in risks were demonstrated.

Finally, although phloretin showed a protective trend, its effect on functional recovery, such as grip strength, did not reach statistical significance in the LLC model and was only modestly significant in the C26 model.

He found that these learning effects are modestly significant and flow fairly easily internationally.

The detection of a single associated pathway, despite an excess of modestly significant p-values, also suggests that (as in GWAS) larger samples are needed.

Similarly, for the PA14 Δ pelA + pelA complemented strain, a modestly significant change, in this case, a decrease, in CFU/mL was observed (Fig. 2d ).

After correction for multiple comparisons, we found a modestly significant association between a haplotype in the GABA-β1 receptor subunit with motor limitation scores.

In a large population-based cohort study of postmenopausal women with a history of oral bisphosphonate exposure, the use of Dmab was associated with a modestly significant 13% decreased risk of subsequent breast cancer, suggesting a potential protective effect of Dmab use on breast cancer risk in older women previously treated with bisphosphonates [ 34 ].

The p values associated with those r values were modestly significant, that is probably a reflection of a modest statistical power in the setting of a small sample.

For Scr, a few subgroup tests yielded borderline or modestly significant differences, yet all subgroups maintained the same direction of effect, and none contradicted the overall finding.

The authors have also found the change in investor sentiment modestly significant (at 10% level), which is not significant in our results either.

The two remaining conditions, ethanol and salt, had modestly significant QTL peaks at this locus, but shared a stronger peak on chromosome IV ( Figure 2 and Table S9 ).

We found a modestly significant increase in the dose–response association in relation to cataracts in workers born before 1960.

Indeed, since this study included only a small number of samples, with only modestly significant sites, the validation of such significant sites is important.

Aβ 1-42 had a modestly significant association with CSF CEC in SH-SY5Y cells but not in N9 cells (Supplemental Figure 6 ).

Thus, having a “neutral” attitude and assuming prior odds for H0 = 1:1, p -values of 0.001 (as reported in a study on tension headache [ 12 ]) would give a modestly significant (0.043) posterior probability.

Among 11 tests of differences in time for predictor variables, only one had a modestly significant P value (0.03).