“indeterminate significance”

Clonal hematopoiesis of indeterminate significance Clonal hematopoiesis of indeterminate potential (CHIP) is a hematologic disorder characterized by age-related acquisition of mutations in hematopoietic stem cells [ 65 ], leading to a clonal myeloid cell population that is associated with increased systemic inflammation [ 66 ].

Nonspecific findings (defined as radiologic abnormalities of indeterminate significance requiring follow up as reported by the radiologist) were detected in 89 SIs (68 CT scans, 19 bone scans and two abdominal ultrasounds), which triggered a total of 138 follow-up radiological scans in 71 (42%) of the 168 patients that had initial Sis, including: CT scan (n = 75), ultrasound abdomen (n = 29), MRI liver (n = 14), bone scan (n = 4), chest X-ray (n = 5), bone X-ray (n = 5), MRI spine (n = 4) and PET scan (n = 2).

Findings include bilateral calcifications of indeterminate significance, with the breast showing a mixture of fatty and dense fibrous tissues.

False positivity represents another challenge that hinders the accurate interpretation of ctDNA, which could arise due to the detection of clonal hematopoiesis of indeterminate significance (CHIP) that is not tumor-specific ( 18 ).

Even though there is growing evidence that clonal hematopoiesis of indeterminate significance may indeed be more prevalent in AID-patients compared to the general population, this need not necessarily be true compared to cancer patients. 125 , 126 The increased preexisting genomic hits and germline mutations in this patient group may further confound the extrapolation. 127 Conversely, the integration of genetic sequences into the host genome—even when restricted to T cells and despite advances in vector safety—carries the potential risk of insertional mutagenesis, which may drive malignant transformation.

Of the three false-positive CT results two described small pulmonary nodules of indeterminate significance, which were unchanged on follow-up CT, and one described a liver lesion that was too small to characterise, but was shown to be a cyst on subsequent US.

The patient was identified to have a heterozygous variant of indeterminate significance for neurogenic differentiation factor 1 ( NEUROD1 ) ( NM_002500.4 ), c.514C > T, p.(Leu172Phe).

3 . One patient had a second larger nodule within the same lobe of the thyroid described as a ‘well defined, slightly hypoechoic vascular nodule’ of indeterminate significance.

In the study by Deandrea et al., the smears diagnosed as follicular lesions of indeterminate significance and follicular neoplasm had a RoM of 4.95% and 25% each.

Within the measurement error of mSASSS, that scores of 1 is intermediate, and perhaps of indeterminate significance.

The nodule was of indeterminate significance and etiology.

His medical history included hepatocellular carcinoma (HCC), type 2 diabetes, and monoclonal gammopathy of indeterminate significance.

Somatic Mutations in Hematopoietic Stem Cells Age-related somatic mutations in hematopoietic stem cells may result in clonal hemopoiesis of indeterminate significance (CHIP), which increases the risk of hematologic malignancies, CVD and overall mortality [ 98 , 99 ].

reported that 47.3% of endocrinologists opted to repeat FNA in cases of AUS/FLUS (follicular lesion of indeterminate significance), while only 14.1% selected molecular testing due to its limited availability [ 20 ].

Imaging also revealed bilateral pulmonary nodules of indeterminate significance that were felt to be unrelated to the migration.

A cervical biopsy was performed if women had abnormal cytology results (e.g., atypical squamous cells of indeterminate significance or more severe lesions), positive HPV results, or abnormal results from colposcopy.

Rare variants of indeterminate significance were discovered in CPP families with maternal transmission [ 21 ].

(0 and 1 were collapsed since 1 represents signal hyperintensity on T2-weighted images of indeterminate significance.) Meniscal damage was scored as: 0: normal, 1: intra-substance signal, 2: tear, 3: maceration/resection.

Lucencies between 1 and 2 mm are generally considered to have indeterminate significance while lucencies < 1 mm are unlikely to be of clinical significance[ 13 ].

However, the usefulness of FNAC is limited when dealing with follicular lesions presenting cellular atypia of indeterminate significance (Thy3), for which the distinction between benign and malignant lesions is ambiguous [ 11 ].

Cytogenetics and molecular screening revealed abnormal karyotype in two patients (of 16 available [12.5%]; one patient with del(Y) and one patient with dup(2)) and a mutation in DNMT3A (p.L373V, variant allele frequency [VAF]: 10.3%) in one patient (of 12 available [8.3%]) consistent with the presence of clonal haematopoiesis of indeterminate significance (CHIP) or clonal cytopenia of undeterminate significance.

This showed a 2 mm round right apical lung nodule of indeterminate significance.

Clonal heterogeneity of indeterminate significance [ 30 , 31 ] has been described and although it doesn’t warrant immediate changes to patient care, it is being monitored carefully in a variety of settings.

A computerised tomography (CT) scan of the thorax, abdomen and pelvis was performed demonstrating a cluster of sub-centimetre lymph nodes in the right paracolic gutter of indeterminate significance.

americanum ticks is currently of indeterminate significance to human health.