“indeterminate significance”

Clonal hematopoiesis of indeterminate significance Clonal hematopoiesis of indeterminate potential (CHIP) is a hematologic disorder characterized by age-related acquisition of mutations in hematopoietic stem cells [ 65 ], leading to a clonal myeloid cell population that is associated with increased systemic inflammation [ 66 ].

Altogether we scored the variant as of Indeterminate significance [ 4 ].

reported that 47.3% of endocrinologists opted to repeat FNA in cases of AUS/FLUS (follicular lesion of indeterminate significance), while only 14.1% selected molecular testing due to its limited availability [ 20 ].

The laboratory reported that the variant was of “indeterminate significance” and yet that it may increase cancer risk.

Overall, 10-15% of FNAs provide inadequate results, while a diagnosis of follicular/oxyphilic lesions of indeterminate significance is made in 10-20% of FNAs 5 .

Imaging also revealed bilateral pulmonary nodules of indeterminate significance that were felt to be unrelated to the migration.

Clonal hematopoiesis of indeterminate significance (CHIP) refers to somatic mutations that occur within hematopoietic stem cells and is associated with increased cardiovascular risk, including myocardial infarction, and decreased overall survival. 83 , 84 Interestingly, an increased prevalence of CHIP has been noted in patients who have received pr

At the conclusion of the dosing phase, microscopic findings of indeterminate significance were observed in the livers of some female animals.

In terms of cytological diagnosis, 13 (1.6%) samples were classified as nondiagnostic, 202 (24.6%) as benign, 147 (17.9%) as indeterminate (142 atypia of indeterminate significance/follicular lesion of indeterminate significance AUS/FLUS, and 5 follicular neoplasm/suspicious for follicular neoplasm FN/SFN), 92 (11.2%) as suspicious for malignancy (SUSP), and 368 (44.8%) as malignant.

About 20% of the cytology results from thyroid FNA come back as an indeterminate result, which includes atypia or follicular lesion of indeterminate significance (Bethesda III) (AUS/FLUS) and follicular neoplasm/suspicious for follicular or oncocytic (formerly Hurthle) neoplasm (Bethesda IV) [ 2 ].

EUS showed a homogeneous hypoechoic lesion in the cephalicregion of uncinate pancreas process and fine needle puncture showed cells with atypia of indeterminate significance.

In addition, in a series of 270 nodules with atypia of indeterminate significance evaluated by means of semi-quantitative USE, Cakir et al.

A CT scan of the chest demonstrated punctate lung nodules of indeterminate significance.

A cervical biopsy was performed if women had abnormal cytology results (e.g., atypical squamous cells of indeterminate significance or more severe lesions), positive HPV results, or abnormal results from colposcopy.

USE is unlikely to be useful in terms of altering the clinical decision of whether to perform FNAC for nodules that are already very suspicious for malignancy or completely benign on conventional US. Another potential role for USE is for nodules with non-diagnostic or indeterminate cytological results on FNAC (e.g., cellular atypia of indeterminate significance), which affects approximately 30% of FNACs [ 61 – 63 ].

Atypical cells of indeterminate significance were divided according to their place of origin: glandular or squamous, AGG or ASC, respectively.

Posttreatment tumour contrast retention often seen on CT immediately post procedure is of indeterminate significance.

33 (9.19%) samples were classified as non-diagnostic (Bethesda I), 149 (41.50%) as benign (Bethesda II), 47 (13.10%) as atypia of indeterminate significance/follicular lesion of indeterminate significance (AUS/FLUS, Bethesda III), 7 (1.95%) as follicular neoplasm/suspicious for follicular neoplasm (FN/SFN, Bethesda IV), 17 (4.74%) as suspicious for malignancy (SUSP, Bethesda V), and 123 (29.53%) as malignant (Bethesda VI).

We combined cartilage grades 0 and 1, since a grade 1 lesion is of indeterminate significance and there were very few participants with grade 1 cartilage defect.

in 2002 demonstrated that a negative 18 F-FDG PET scan predicts stable monoclonal gammopathy of indeterminate significance (MGIS), identifies small lesions not detected by WBSS, identifies extra-medullary lesions related to poor prognosis and predicts an early relapse if it was positive after therapy [ 21 ].

Nonspecific findings (defined as radiologic abnormalities of indeterminate significance requiring follow up as reported by the radiologist) were detected in 89 SIs (68 CT scans, 19 bone scans and two abdominal ultrasounds), which triggered a total of 138 follow-up radiological scans in 71 (42%) of the 168 patients that had initial Sis, including: CT scan (n = 75), ultrasound abdomen (n = 29), MRI liver (n = 14), bone scan (n = 4), chest X-ray (n = 5), bone X-ray (n = 5), MRI spine (n = 4) and PET scan (n = 2).

Magnetic resonance imaging (MRI) of the brain with contrast similarly showed no acute intracranial findings but did reveal a new punctate enhancement in the left medial orbital gyrus of indeterminate significance and inflammatory changes within the paranasal sinuses.

In most MM patients, a premalignant state called Monoclonal Gammopathy of Indeterminate Significance (MGUS) is found, which precedes MM.

The use of fine needle aspiration of a thyroid mass can be considered; however presence of cytology of indeterminate significance including follicular proliferation and atypia of undetermined significance in between 5 and 20% of cases limits the use of this method [ 2 ].

Limitations The current study has some notable limitations, first and foremost among which is our small sample size, possibly explaining the indeterminate significance of some findings.