“indeterminate significance”

The significance of these restrictions can be understood by considering clinically-impactful categories of lymph node metastases, including those that are greater than 0.2 cm (significant), micrometastases between 0.02 to 0.2 cm (indeterminate significance), and isolated tumor cells less than 0.02 cm (low significance) 1 , 3 .

Alteration in Malignancy Rate with the Introduction of Non-Invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) Since significant portions of noninvasive FVPTCs are categorized as atypia of indeterminate significance (AUS), suspicious for follicular neoplasm (SFN) and suspicious for malignancy (SUS), the greatest impact of this new nomenclature was expected in these categories [ 6 , 16 , 17 ].

The cytology specimens were classified as normal (negative for malignancy), reactive changes, squamous atypia of indeterminate significance (ASCUS), low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), and invasive carcinoma. 2.2.

Magnetic resonance imaging (MRI) of the brain with contrast similarly showed no acute intracranial findings but did reveal a new punctate enhancement in the left medial orbital gyrus of indeterminate significance and inflammatory changes within the paranasal sinuses.

The "indeterminate" result represents a "gray" diagnostic area, which occurs in 5–20% of cytological reports with the presence of cellular atypia of indeterminate significance (TIR3 category) [ 11 ].

A chromosomal microarray revealed a small duplication on Xq13.2 which was of indeterminate significance after consultation with the Genetics Team.

A potential pathogenic connection with the prior viral infection may be suspected, yet of indeterminate significance at this point [ 42 , 43 ].

However, FNAC is characterized by a grey diagnostic area (Thy3) due to the finding, in about 10% of the specimens, of cellular atypia of indeterminate significance which precludes a distinction between benign and malignant lesions [20] .

An indeterminate result represents a “gray” diagnostic area, estimated to occur in 5–20% of cytological reports with the presence of cellular atypia of indeterminate significance (TIR3 category) [ 66 ].

In terms of cytological diagnosis, 13 (1.6%) samples were classified as nondiagnostic, 202 (24.6%) as benign, 147 (17.9%) as indeterminate (142 atypia of indeterminate significance/follicular lesion of indeterminate significance AUS/FLUS, and 5 follicular neoplasm/suspicious for follicular neoplasm FN/SFN), 92 (11.2%) as suspicious for malignancy (SUSP), and 368 (44.8%) as malignant.

Posttreatment tumour contrast retention often seen on CT immediately post procedure is of indeterminate significance.

In addition, there are several mildly FDG avid mediastinal, left hilar, and upper abdominal nodes seen, which are of indeterminate significance.

Our predictive model based on conventional US features and BRAF V600E shows that combining capsule contact, C-TIRADS, and BRAF V600E mutations can assist in distinguishing the benignity and malignancy of thyroid nodules with indeterminate significance.

The area under the glucose curve was lower in caffeine-treated subjects, but with indeterminate significance [ 19 , 22 , 24 ].

Imaging revealed several nondistinct nodules of indeterminate significance along the course of the superficial peroneal nerve (SPN).

Cytological diagnosis from FNA samples typically follows the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), categorizing nodules into clearly benign (Bethesda II) and malignant (Bethesda VI), as well as categories with indeterminate significance, notably Bethesda III (atypia of undetermined significance [AUS]) and Bethesda IV (follicular neoplasm [FN]) [ 4 , 5 ].

We analyzed 2 groups of variants found in 8 genes with definitive evidence for HCM ( 3 ): sarcomeric variants P/LP specifically for HCM (SARC-HCM-P/LP) and rare sarcomeric variants of indeterminate significance (SARC-IND) with the potential to cause HCM, dilated cardiomyopathy (DCM), or have little impact on cardiomyopathy risk.

Routine parafibromin stain in maxillary and mandible masses amid HJT is currently incompletely implemented in daily practice, having yet an indeterminate significance.

Experts spoke of overdiagnosis as being of indeterminate significance because of uncertainty about the overdiagnosis rate.

Interestingly, the inherited bone marrow failure molecular panel detected a heterozygous SAMD9 variant of indeterminate significance.

This renders the fine-needle aspirates (FNA) of thyroid follicular nodules useless for diagnostic purposes and biopsies not allowing for determination of the lesions malignant potential are determined as of indeterminate significance [ 5 ].

The term clonal hematopoiesis of indeterminate significance (CHIP) was introduced to describe individuals with a hematologic malignancy-associated somatic mutation in peripheral blood or bone marrow cells but without any other diagnostic criteria for a hematologic malignancy. 107 CHIP must be distinguished from myelodysplastic syndromes (MDS) by the absence

EEG may reveal periodic epileptiform patterns of indeterminate significance, similar to our patients' EEG findings.

Fine-needle aspiration cytology of the cervical thyroid gland resulted in the lesion being classified as of “indeterminate significance,” and a pathological examination of a needle biopsy sample from the same site led to the lesion being diagnosed as a follicular neoplasm.

The rest of the categories (Bethesda class I – inadequate; Bethesda class III – atypical cells or follicular cells of indeterminate significance; Bethesda class IV – follicular neoplasm; and Bethesda class V – suspicious for malignancy) were considered non-diagnostic and were included in the final analysis only if surgical histopathology was available.