“indeterminate significance”

EEG may reveal periodic epileptiform patterns of indeterminate significance, similar to our patients' EEG findings.

However, FNAC is characterized by a grey diagnostic area (Thy3) due to the finding, in about 10% of the specimens, of cellular atypia of indeterminate significance which precludes a distinction between benign and malignant lesions [20] .

The nodule was of indeterminate significance and etiology.

An indeterminate result represents a “gray” diagnostic area, estimated to occur in 5–20% of cytological reports with the presence of cellular atypia of indeterminate significance (TIR3 category) [ 66 ].

Diagnostic imaging included a CT head without contrast that demonstrated rounded hyperattenuating focus in the frontal horn of the bilateral lateral ventricle measuring approximately 9 × 7 mm (right) and 5 × 4 cm (left) transaxially, of indeterminate significance ( Fig. 1 ).

Alteration in Malignancy Rate with the Introduction of Non-Invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) Since significant portions of noninvasive FVPTCs are categorized as atypia of indeterminate significance (AUS), suspicious for follicular neoplasm (SFN) and suspicious for malignancy (SUS), the greatest impact of this new nomenclature was expected in these categories [ 6 , 16 , 17 ].

The cytology included were: Atypical squamous cells of indeterminate significance (ASC-US); atypical squamous cell of undeterminated significance which can not be excluded from high-grade intraepithelial lesions (ASC-H); low-grade squamous intraepithelial lesion (LSIL); high-grade squamous intraepithelial lesion (HSIL); squamous carcinoma; atypical glandular cells of undetermined significance (AGC-NOS); atypical glandular cells favor neoplasic (AGC-H); and atypical cells with undertemined origin (ACs) ( Table 1 ).

In addition, MRI of the abdomen was obtained with and without contrast was suggestive of hepatomegaly, ascites, and deep mesenteric and retroperitoneal lymphadenopathy measuring 2.5 x 1.5 cm of indeterminate significance.

Chest X-ray showed mild bronchial wall thickening in the right lower zone with a few ill-defined small opacites of indeterminate significance.

[ 17 ] conducted a study on patients with thyroid nodules and indeterminate significance on FNA reported that the higher the BMI was, the lower the malignancy rate was except for women aged 45 or older.

[ 41 ] However, while the utility of scripted patient communication tools is of indeterminate significance on the patient experience, there is ample evidence supporting the educational utility of the learning framework of our intervention.

Discussion The increasing availability of NGS has led to the discovery of a multitude of novel mutations of, in part, indeterminate significance in AML, as well as other malignancies [ 9 , 17 ].

The results of cytology testing reported that 48 (8.5%) women had cervical abnormalities, which included 16 (2.8%) classified as ASCUS (Atypical Squamous Cells of Unknown Significance), 6 (1.1%) classified as ASCH (Atypical Squamous Cells of Indeterminate Significance), 16 (2.8%) classified as LGSIL (Low-Grade Squamous Intraepithelial Lesion), 4 (0.7%) classified as HGSIL (High-grade squamous intraepithelial lesion), and 6 (1.1%) classified CIN II + CIN III (Cervical Intraepithelial Neoplasia) (Table 1 ).

The cytology specimens were classified as normal (negative for malignancy), reactive changes, squamous atypia of indeterminate significance (ASCUS), low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL), and invasive carcinoma. 2.2.

His medical history included hepatocellular carcinoma (HCC), type 2 diabetes, and monoclonal gammopathy of indeterminate significance.

The area under the glucose curve was lower in caffeine-treated subjects, but with indeterminate significance [ 19 , 22 , 24 ].

Somatic Mutations in Hematopoietic Stem Cells Age-related somatic mutations in hematopoietic stem cells may result in clonal hemopoiesis of indeterminate significance (CHIP), which increases the risk of hematologic malignancies, CVD and overall mortality [ 98 , 99 ].

This omission may be due to difficulties with the collection of adequate and appropriate specimens in younger patients, the indeterminate significance of these organisms in the CF population, and a lack of awareness and consistency among providers in obtaining NTM cultures as part of routine CF care [ 7 ].

0 and 1 were collapsed since 1 represents signal hyperintensity on T2-weighted images of indeterminate significance, hence the analysis variables ranged from 0–3.

Fine-needle aspiration cytology of the cervical thyroid gland resulted in the lesion being classified as of “indeterminate significance,” and a pathological examination of a needle biopsy sample from the same site led to the lesion being diagnosed as a follicular neoplasm.

9 Our patient’s case is unusual in that, based on gene sequencing, laboratory, and clinical findings, she is a compound heterozygote for a previously unreported nonsense mutation and a missense mutation of indeterminate significance ( Figure 1 ).

Imaging revealed several nondistinct nodules of indeterminate significance along the course of the superficial peroneal nerve (SPN).

The rest of the categories (Bethesda class I – inadequate; Bethesda class III – atypical cells or follicular cells of indeterminate significance; Bethesda class IV – follicular neoplasm; and Bethesda class V – suspicious for malignancy) were considered non-diagnostic and were included in the final analysis only if surgical histopathology was available.

Lung nodules of indeterminate significance are discovered in over 25% of the individuals screened with CT. 32 As revealed by expensive and invasive diagnostic tests used to discriminate these lesions, 96% of these hard to distinguish nodules are benign. 33 The development of a simple, rapid, specific, noninvasive, and clinically relevant diagnostic tool would improve early lung cancer detection, reduce the need for unnecessary biopsies, and enable early treatment.

In the study by Deandrea et al., the smears diagnosed as follicular lesions of indeterminate significance and follicular neoplasm had a RoM of 4.95% and 25% each.