“highly significant”

While rs7041 only had a modest statistical association in our single-SNP GWAS ( p =2.8×10 −4 for antenatal and p =0.01 for cord blood), the results for haplotype association ( Table 4 ) were highly significant (ANOVA p =2.0×10 −7 for antenatal and p =3.0×10 −6 for cord blood).

This is highly significant in EUR, when compared to the negative control regions, and modestly significant in ASN (<p = 2x10 -7 and p = 0.01 for EUR and ASN, respectively) and appears inconsistent with the null hypothesis of neutral evolution and demography at the LCT locus especially in the EUR populations.

In the HeLa cell line, BiP-MSR-3x had 53 times lower reporter activity than BiP-MSR-4x, a highly significant difference (Mann-Whitney U = 168, n1 = 14, n2 = 12, p < 2 × 10 −7 ).

Here we found clear differences between non-smokers (2.12 ± 2.07 μg/g creatinine) and smokers (411.37 ± 351.41 μg/g creatinine) that are highly significant (p = 2 × 10 −7 ).

However for responses evoked by octopamine and dopamine the correlation is high and highly significant (OA: r s = 0.93, p = 2e-7 [n = 24 responses from 6 oocytes]; DA: r s = 0.97, p = 2e-7 [n = 14 responses from 5 oocytes]).

However, according to the Spearman rank correlation analysis the expression of IGF-IR and VEGFR-2 was highly positively correlated and statistically highly significant (r = 0.745 and p = 0.0000002) ( Figure 7 ).

This comparison revealed 56 common genes, representing a highly significant intersection ( Table S2 , P = 2E-07).

When considered together, the 19 methylation biomarkers demonstrated exceptional predictive power, with an AUC of 0.95 and an accuracy of 0.88 at a highly significant P = 2.02e-07 ( Fig. 2 A ).

Among the 401 genes implicated in ID, we identified 106 genes coding for GRFs, which represents a highly significant enrichment of GRFs among all ID genes (hypergeometric test, p = 2.03 × 10 −07 ).

For the four higher concentrations, there are highly significant differences among groups (10 −2.5 F 3,76 = 14.145 *** p = 2.05 × 10 −7 ; 10 −2 F 3,76 = 60.371 ***, p = 4.56 × 10 −20 ; 10 −1.5 F 3,76 = 50.504 ***, p = 4.63 × 10 −18 ; 10 − 1 F 3,76 = 26.148 ***, p = 1.01 × 10 −11 ; *** = p < 0.001).

The effect of growth forms was insignificant in the Asteraceae and the Brassicaceae, possibly due to the limited number of non‐herbaceous species, but the effect was highly significant in the Solanaceae where non‐herbaceous species are abundant ( p = 2.078 × 10 −7 ).

Polygenetic risk score (PRS) constructed by using three independent SNPs (rs1410996, rs4698775, and rs2043085) showed highly significant association with CSC ( p = 2.10 × 10 –7 ), with the top 10% of subjects with high PRS showing 6.39 times higher risk than the bottom 10% of subjects with lowest PRS.

The cross-validated model was highly significant for the difference between matched case and control sample (p = 2.1*10 −7 ).

While saliva sample volume remained the variable with the largest effect (P = 6.8x10 -27 ), DNA turbidity and purity where highly significant at P = 2.1×10 -7 and P = 1.8×10 -4 , respectively.

The association between p57 negativity and CHMs was highly significant (χ 2 = 26.94, p = 2.1 × 10 −7 ; Fisher’s exact p < 2 × 10 −7 ).

Fisher’s exact test revealed a highly significant ( P = 2.13e−07) association between viruses in the species Magarnavirus gigas (proposed) and oysters with obvious signs of disease, when compared to naturalized beach oysters with no sign of disease.

This gene score and anxiety had a highly significant interaction effect on WM ( p = 2.14E−7).

Upon adjusting our linear models for these cell fractions, the hypomethylation at cg19803194 remained highly significant (adjusted p-value = 2.14 × 10 − 7 ).

was markedly stronger at 37°C ( r = 0.799) than at RT ( r = 0.587), yielding a highly significant Fisher's Z statistic ( Z = −5.18, p = 2.23 × 10 − 7 ) and a back‐transformed 95% confidence interval that excluded zero (−0.53 to −0.26).

In ErbB4-transfected cells, as expected, NRG1 induces a highly significant increment in the number of migrated cells (P = 2.24E-07), while NMDA alone does not significantly alter basal migration (P = 0.986).

The Kruskal–Wallis test confirmed a highly significant group effect (H = 36.48, p = 2.30 × 10 −7 ), supporting the robustness of the observed intergroup differences.

The effect of motion coherence on the perceived direction separation was highly significant (one-way ANOVA, F(5,18) = 24.3, p = 2.3×10 −7 ).

The recombination rate in females is notably higher near the centromere, whereas in males it is higher near the telomere (a highly significant difference: p = 2.3 × 10 −7 ), similar to the pattern observed in humans.

However, combining the EU, AA, and CH groups revealed a highly significant association of ARC SNP rs35900184 (p = 2.353 x 10 −7 ; OR [95% CI] = 1.54 [1.310–1.820]).

One-way ANOVA confirmed a highly significant effect of drying method on TAC (F(3,8) = 148.6, p = 2.36 × 10 −7 ), and Tukey’s HSD test classified the methods into three distinct groups: freeze drying (a), oven/sun drying (b), and vacuum drying (c).