“highly significant”

The overall difference in detection rates for culture and MDx was very highly significant, p -value = 2.384 × 10 −7 .

Multiple analysis by the number of all risk genotypes showed a highly significant association with CAP ( P = 2.4×10 -7 , OR = 3.03, 95% CI 1.98 to 4.64) with the threshold for three risk genotypes.

PLR latency We identified four highly significant differentially methylated probes associated with three PLR latency phenotypes at a stringent p-value threshold ( p < 2.4 × 10 − 7 , see Table 2 ).

The turquoise (#12) module had a highly significant overlap with synaptic proteins in general ( P =2.4e−7), but the blue (#2) module was not enriched in synaptic proteins ( Figure 5B ).

Although these SNPs were highly significant (p-value < 2.47 × 10 –7 ) with strong effects on CW, due to their low minor allele frequency (0.01 ≤ MAF < 0.023) their contribution to the genetic variance of the trait was relatively small (0.09–1.28%).

One gene demonstrated a highly significant association that satisfied the empirical Bonferroni’s correlation ( p =2.5×10 −7 , effect size=−1.19, R6FCZ7).

Note, however, that in the same time, both haplotype based tests reveal a number of significant SNPs (one highly significant, p = 2.5×10 −7 , in the case of linear regression) among those within the transcript itself and used as informative markers for the detection of AI.

Results There was a highly significant positive correlation between the total number of YGLs in a country and the median (ρ = 0.36, p = 2.5×10 -7 ) and maximum (ρ = 0.34, p = 1.6×10 -6 ) GRSI during the second wave of the pandemic, but not during the first wave.

Differences in rapidity and severity of systemic signs An ANOVA analysis of the differences among the strains with respect to the rapidity of the development of the first signs of systemic disease produced extremely highly significant results: p = 2.5 × 10 -7 .

1c ), the estimate of MAE was almost unchanged and remained highly significant ( β = 0.047, P = 2.56 × 10 –7 ), whereas the estimate of PAE decreased substantially and became nonsignificant ( β = 0.015, P = 0.08).

The nuclear ancestry was statistically different between the alleles of seven of the eight SNPs assessed by chi-squared test; m.1438, m.3197, m.4769, m.10398 and m.15043 were statistically highly significant (P-value = 2.6e -7 , 1.34e -6 , 2.45e -7 , 2.2e -16 2.2e -16 respectively) and m.3666 and m15218 were statistically significant (P-value = 0.002 and 0.008 respectively whereas m.9377 was not statistically different.

In analyses including all NSCLC patients, PRSS3 gene expression showed highly significant association with both poor OS (HR 1.47, P = 2.6e-7; Fig. 1a ) and poor PFS (HR 2.15, P = 2.7e-11; Fig. 1b ).

The inheritance pattern shows a very highly significant deviation from the null hypothesis (χ 2 = 21.5; P = 2.6 × 10 −7 ) ( Table 1 ).

Notably, a look-up in the independent deCODE QRS duration analysis showed that rs61736454 was highly significant, however not exome-wide ([ P = 2.65 × 10 −7 , β(SE) = 3.01(0.58)], MAF = 0.002, N = 59,903), and was extremely well imputed (info score = 0.995).

Interestingly, 76% (462 out of 605) of genes showing downstream shifts in both fast Pol II strains also exhibit upstream shifts in both slow Pol II strains, an overlap that is highly significant ( Figure 4E and F , and Figure 4—figure supplement 1 ; p=2.68×10 −7 ).

3 a); (2) SNPs located at DNase I hypersensitive sites showed highly significant enrichment in several tissues, with colon identified as the most significant enrichment (OR = 5.10, P = 2.74 × 10 −7 ) (Fig. 3 b); (3) SNP enrichment in different chromatin state associated regions revealed that the transcribed regions were significantly enriched in different tissues (embryonic stem cell: OR = 6.18, P = 4.25 × 10 −8 ; liver: OR = 5.55, P = 5.26 × 10 −8 ; blood: OR = 5.13, P = 1.76 × 10 −7 ) (Fig. 3 c).

We indeed find statistically highly significant negative correlations between the predicted tRNA/ribosome gene dosage ratio (Eq ( 21 )) and μ max ( Fig 3D ; slowly growing species: ρ = −0.44, P = 2.8×10 −7 , P ic = 6.0×10 −4 ; fast-growing species: ρ = −0.49, P = 4.3×10 −4 , P ic = 0.037) (see Text C in S1 File for the treatment of tRNA genes; these calculations assume a constant DNA replication rate k rep = 1000 s -1 across species, see Text A in S1 File for species-specific replication rate k rep ).

The full model was found to be highly significant when compared with the null model ( X 2 : 41.029, p = 2.9 × 10 −7 ).

), a locus that had previously been considered by Australian[ 96 ] and Swedish researchers.[ 97 ] In a follow-up study involving collaborators from the UK and Belgium, these US researchers studied 197 multiplex families, 1,901 trio families, 1,515 cases and 3,204 unrelated controls and identified a highly significant association ( P = 2.9 × 10 −7 ) with rs6897932 a non-synonymous SNP (nsSNP) from exon 6 of the IL7R gene,[ 98 ] a result which was replicated in an accompanying paper from Swedish researchers.[ 99 ] This locus was thus the first non-MHC susceptibility gene to be identified in multiple sclerosis.

The model shows that after controlling for coexpression and intergenic distance, bipromoter status still has a highly significant effect on gene pair conservation ( P = 2.9 × 10 −7 ); the effect of orientation was indeed much stronger than the influence of the other two variables (data not shown).

This trend continues on day 7 where a highly significant correlation between sodium and copper was observed (R 2 = 0.8, p = 2.96e -7 ).

After excluding genesets driven solely by one highly significant gene, two genesets remained significant: ‘GOBP: regulation of mRNA splicing via spliceosome’ ( GO:0048024 , 96 genes, P = 2.97 × 10 −7 ) and its parent term ‘GOBP: regulation of RNA splicing’ ( GO:0043484 , 142 genes, P = 3.50 × 10 −6 ) (Fig. 2d and Extended Data Fig. 3d ).

The difference between these proportion was highly significant ( χ 2 = 26.87, d.f. = 1, p < 0.0000003).

Moreover, highly significant correlations Moreover, highly significant correlations were observed in the scatter plot of GS and MM within the MEbrown module (cor = 0.31, p = 3e − 7, Fig.

There was a highly significant difference in 4-year PFS between the maintenance and observation group (56% vs 33%, P =0.0000003), and the median PFS was increased by almost 4 years in the maintenance group (61 vs 15 months).