“extremely significant”

This difference is extremely significant with a p-value <1.04×10 −21 .

The GCGC haplotype combination of the 2677G>T, 3435C>T, 1249G>A and −24C>T respectively was found to be extremely significant (p = 1.10e−20) with good drug response to CBZ mono-therapy.

Co-ingestion of tablet L-T4 and any interfering drug(s) was associated with serum TSH levels approximately 100% greater than those associated with ingestion of tablet L-T4 alone, the difference being extremely significant (P = 2.2 × 10 −20 ).

The bacterial reduction was also extremely significant for the film loaded with SSD ( p = 2.42016 × 10 −17 ).

This study not only found linkage to 4q23 but also identified extremely significant associations (p = 8.0 × 10 −17 ) with variants in or near the nearby gene UGT8 , though it is not yet clear whether the causal variants driving this signal have been identified 17 .

We did a survival analysis with the 82 commonly downregulated genes in lung cancer using KM plotter, and an extremely significant favorable outcome was associated with higher expression of the set of genes (H = 0.35, p < 1 × 10 −16 ) in lung cancer patients ( Figure 4 C).

This yielded a PPI with 235 edges with an extremely significant enrichment p -value < 1.0e−16 ( Fig. 10 ).

I do think it is appropriate to highlight those smooth terms which are extremely significant (p<2e-16) according to this test.

Of the 1,070 autosomal DEGs, 975 were also assigned to these modules, which was an extremely significant enrichment (Fisher’s exact test P value <2.2E-16, SI Appendix , Table S2 ).

The difference between the electrolytic approach (test groups 1, 3, and 5) and PSS (control groups 2, 4, and 6) was statistically extremely significant ( p -value < 2.2 × 10 −16 ).

Given the large ExAC data sets sampling 60,706 individuals, the differences were extremely significant (p-value < 2.2e-16).

Additionally, the FarmCPU model identified extremely significant SNP for somatic cell count, fat percentage, and total dry matter percentage traits, located on chromosome 13 (13:2275920, P = 4.14 × 10 −16 ), chromosome 3 (3:14938807, P = 5.75 × 10 −18 ), and chromosome 20 (20:66155928, P = 1.03 × 10 −18 ), respectively. 3.5 Positional candidate genes To further investigate the molecular markers and functional genes related to economic traits in goat milk, we identified genes within a 50 kb range upstream and downstream of the significant SNP as positional candidate genes.

For extremely significant results (e.g., P < 1 × 10 −15 ), the software restricts output to 15 decimal places; in these cases, we report the smallest displayable value to ensure transparency and reproducibility.

While we estimate that this stringent quality control produced well calibrated association test statistics for more than 99% of sites, this analysis yielded many extremely significant p-values at SNPs outside of known loci (e.g. ~7,000 with p < 10 -15 ), 95% of which had an allele frequency below 5%.

Additionally, the ANOVA for all three metrics showed extremely significant differences ( P < 1e-15, F-value > 100), indicating a statistically significant performance difference between GrainNet and YOLOv7.

In the case of PQ11 and PQ28, the very strongly positively correlated traits, the clusters of GBS, F87, and F24 showed extremely significant differences (p-value < 2.2e−15).

10 b), and the Wilcoxon test showed that the ionic bond changes between the positive and negative variants were extremely significant ( p = 2.7E − 14).

Our results indicate that an extremely significant difference exists in the proportions of isolates from high, medium and low incidence regions for I-A8 and the remaining branches (P = 9.126×10 −14 ).

The enrichment of NO‐related genes in the differentially expressed genes was statistically extremely significant (chi‐squared test, P < 10 −12 ).

The association of the western part of Eurasia (Central and West Asia and Europe) mtDNA types was extremely significant in haplogroup I ( P = 3.96E-12), haplogroup L ( P = 3.8E-17) and haplogroup N ( P = 6.35E-10) under the Pearson χ 2 test (Table 2 ).

Both correlations were extremely significant (p<10 −10 ).

The top four most enriched terms among upregulated genes were extremely significant, with a p -value < 10 −10 .

Interestingly, we found that the rescue of the 259 upregulated genes was extremely significant ( P <<10 −10 ), while the rescue of the 85 downregulated genes was borderline with a chance event ( P =0.052).

43 The threshold value of −log 10 ( P ) was set as −log 10 0.1/201,817 SNP [ P < 4.96E10-7, −log 10 ( P ) value is approximately equal to 6.3] for identifying true marker–trait associations, which was expressed as the false discovery rate (FDR) test value in the R program 44 ; a true marker–trait association should show a FDR of less than 0.05, and only an FDR of less than 0.01 could meet the criteria for extremely significant association with the traits [ P < 4.96E10-8, −log 10 ( P ) value is approximately equal to 7.3]. 2.5.

( 2011 ) gave an extremely significant coefficient of MLS determination ( R 2 = 0.713, P = 6.2E-10, n = 37), which is very close to that obtained on much bigger dataset of mammals ( R 2 = 0.703, P < E − 25, n = 215; unpublished data).