“extremely significant”

Remarkably, among the ~300 predicted modules whose sizes are at least 20, 88% have at least one significantly enriched functions, including a few extremely significant ones (ribosome, p < 1E-300, photosynthetic membrane, p < 1.3E-137, proteasome complex, p < 5.9E-126).

cuniculus , which is extremely significant (r 2 = 0.305, p -value = 6.24 × 10 −295 ); furthermore, H. sapiens shows significant correlations even with M. musculus (r 2 = 0.177, p -value = 2.7 × 10 −113 ) and C. lupus familiaris (r2 = 0.260, p -value = 4.15 × 10 −226 ).

The difference was extremely significant ( p = 7E −202 ).

An extremely significant locus ( P = 4.15 × 10 −198 ) centered at position 9.60 Mb on chromosome 14 ( Fig. 3A ) was identified.

A hypergeometric test showed that there is an extremely significant overlap (256 CpGs) by our 3084 discovery CpGs with their reported CpGs ( p < 1.29e‐111).

However, notably, even after explicitly controlling for prior treatment time in the Cox regression model, the increased expression in all 48 genes in the mesothelioma prognostic signature is still markedly associated with worse patient survival (Fisher’s exact test for enrichment of overlapping genes between explicitly controlling or not controlling of prior treatment is extremely significant, odds ratio = infinity, p = 1.54e−103).

Specially, differential expression of lncRNA FAM83H-AS1 was extremely significant ( P = 1.72E-101, fold change value = 3.781).

Nevertheless, the differences between the case groups (TIO and BM) and the control group (HC) were both extremely significant ( P < 10 −100 ).

HBEC + HDM) was extremely significant for both up-regulated ( p = 7.0 × 10 −93 ) and down-regulated metabolites ( p = 2.8 × 10 −49 ), indicating that core metabolic distinctions between ePNECs and HBECs are strongly preserved following allergen exposure.

The overlap is statistically extremely significant (p = 9.7E-83).

The association of LIPG p.Asn396Ser with plasma cholesterol, HDL-C, and LDL-C is extremely significant (p=10e-74, p=10e-199, p=10e-65), however the association with TG is somewhat weaker, although still genome-wide significant (p=10e-10).

As shown in Figure 1 A, breast tumors demonstrated significant overexpression of EDB-FN (median 36.319 transcripts per million (TPM)), compared to normal breast tissues (median 2.410 TPM), translating to an extremely significant log 2 fold increase of 3.452 (adj p value = 6.57 × 10 −69 ) in breast cancer over normal tissues.

We detected interspecies positive correlations as high as 0.36 ( Figure 2 A), which is extremely significant ( p -value = 1.52 × 10 −68 , Figure 2 B).

The enrichment score generated for the EIF2 canonical pathway enrichment was extremely significant ( P -value = 1×10 −64 ) and the combination of these observations indicates that the gene-list was both predictable (valid with extensive literature) and statistically very robust ( Figure S2 ).

As expected, the culinary oil x time-point first-order interaction effect was also extremely significant for all oils tested ( p < 10 −50 to <10 −18 ), and this ratifies the contrasting responses of each oil type to increasing LSSFE lengths; for example, differential rates and extents PUFA losses from soybean/corn oils and extra-virgin olive/avocado oils ( Figure S1b ), and likewise the contrasting elevations and reductions in oil MUFA contents for these two groups respectively ( Figure S1a ).

The test yielded an extremely significant p -value < 1.0 × 10 −50 .

The possible correlation between the allele frequency of SNP1 and wool production was extremely significant ( P = 2.50E-43) ( Fig. 3 d ).

Moreover, the SII demonstrated a consistent annual increase, with regression results indicating extremely significant statistical relevance (P = 9.3E−40).

The correlation between Π and δ is extremely significant, with Spearman's correlation R = 0.94, z -score 8.4, corresponding to p < 10 −30 (probability for fortuitous generation of such correlated data, under the hypothesis of null correlations).

However, only for HNF1β (HNF1B_MOUSE.H11MO.0.A, [ 14 ]) we found the extremely significant asymmetry within predicted CEs toward the partner motif ( p < 2 × 10 −28 and p < 4 × 10 −17 for CEs with an overlap of motifs and with a spacer, respectively).

This codon is the eighth most frequently mutated codon in CRC and this mutation is extremely significant in our stool sample (P = 2.72e-26, P Bonf = 9.35e-24).

When comparing lung adenocarcinoma vs healthy, the top MSigDB pathway, angiogenesis was extremely significant ( p < 10 −25 ), followed by proliferation-related pathways ( S8 Fig ).

The association of rs4803217 with sustained virological response (defined as absence of detectable HCV RNA in serum at least 24 weeks after discontinuation of treatment) was extremely significant (p = 2.48 ×10 −25 ) in the European-American population ( Table 1 ).

Compared to the random networks, the predicted correlation of the curated network is extremely significant (P-value = 4.04 × 10 -23 ).

The upstream regions of 17 mid-meiotic internal TSS were found to contain MSE sites ( Table 3 ), an extremely significant enrichment (p<1.5x10 -22 , Fisher's exact test).