The expression of monocyte chemotactic protein 1(MCP-1) and regulated upon activation normal T-cell expressed and presumably secreted (RANTES) was significantly increased in the aortas of KO mice, and that of vascular cell adhesion molecule-1 (VCAM-1) showed a trend of increase in KO mice although did not reach statistical significance ( Fig. 2 G).
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Although the reduction in FSH levels among cell-treated patients did not reach statistical significance, there was a clear trend towards a decrease in hormone levels.
Kaplan-Meier-analysis of time to progression, i.e., a 5-fold increase in tumor size to a volume of 1000 mm 3 was considered an event, showed a trend to be improved under combined treatment but did not reach statistical significance (Figure 3B ): median time to progression was 33 days in photon-EBRT vs. 45 days in PERT group (p = 0.054) and 35 days in carbon-EBRT vs. 61 days in CERT group (p = 0.18).
Male sex showed a trend toward higher risk but did not reach statistical significance (adjusted OR 1.56, p = 0.069).
C2 mast cells expressing WWOX shRNAs showed a trend towards increased clonogenic survival at doses of 4 Gy, but this difference did not reach statistical significance ( p = 0.1200).
Colonic Iba1 + myeloid cells showed a trend toward increased abundance, although this change did not reach statistical significance due to substantial interindividual variability.
Beverage mouthing duration showed a trend toward regional differences but did not reach statistical significance in post-hoc comparisons between North Carolina and Arizona ( p = 0.091).
As an exploratory analysis, we examined the relationship between tumorous CA9 mRNA expression and circulating CA9 levels in 32 HCC specimens and observed a positive trend that did not reach statistical significance when assessed by Spearman’s rank correlation ( online supplemental figure 8 , online supplemental table 15 ).
However, although there was a slight trend of increased histamine levels in milk and plasma after LPS infusion, this did not reach statistical significance (Figure S1 in Supplementary Material).
DDIT3/ CHOP levels showed an increasing trend, although the difference between the groups did not reach statistical significance.
Also, there was a trend toward significance in interleukin- 6 (IL-6) levels in the achalasia group, but this difference did not reach statistical significance ( p = .053) [ 5 ].
However, when the different knee regions were analyzed separately, the adjusted p-values did not reach statistical significance, although a clear trend was observed, suggesting that cartilage damage may be more pronounced in the medial femorotibial joint (MFTJ), whereas bone marrow lesions appear to predominate in the patellofemoral joint (PFJ) (Table 3 ).
glabripes showed a trend toward association with OS, these did not reach statistical significance.
Although ECOG PS showed a favorable trend in patients with scores 0–1, this did not reach statistical significance in the adjustment.
Total BALF cells and eosinophils were significantly reduced in the absence of STAT6 in female mice ( Figures 1B,C ); in males, there was a clear trend for BALF eosinophils to be reduced, though this difference did not reach statistical significance ( Figure 1C ).
Although an increasing trend has been observed for STEP 61 expression over the course of 96 h following chronic ECS, this trend did not reach statistical significance due to a large standard deviation ( Figure 1(e) , Supplemental Figure 1).
PPARγ expression also showed a decreasing trend, although it did not reach statistical significance ( Figure 2 C).
Due to the small sample size, the comparison of EORTC scores was not adjusted for differences in baseline characteristics. Global health score ( p -value = 0.077), physical ( p -value = 0.121), emotional ( p -value = 0.293) and social ( p -value = 0.054) functioning scales revealed an increasing trend across time; however these did not reach statistical significance.
While an increased susceptibility to COVID-19 was noted, dapagliflozin showed a trend in reducing the risk of progressing to severe COVID-19, although this trend did not reach statistical significance [ 55 ].
We agree that the is a strong trend in our study in young NAION patients with Tobacco consumption, and although it did not reach statistical significance this may have been due to relatively low sample size.
A second study [ 12 ] compared Eribulin against capecitabine in 1102 patients and showed a trend towards better OS: 15.9 months in Eribulin versus 14.5 in control; however, this difference did not reach statistical significance ( p = 0.056).
Although adjuvant HAIC (HR: 0.57; 95% CI: 0.31, 1.04) and adjuvant sintilimab (HR: 0.51; 95% CI: 0.25, 1.01) did not reach statistical significance, they still showed a favorable trend.
In early-stage patients, those without symptoms showed a trend toward higher hip survival during the first two years; however, the difference did not reach statistical significance (P = 0.370).
In addition, compared with sIL-15 NK cells, FLT3 CAR_sIL-15 NK cells were significantly increased in the BM ( Figure 6 C; supplemental Figure 7 B) and showed a trend of increase in the PB, although the difference did not reach statistical significance ( Figure 6 D; supplemental Figure 7 C).
Notably, while this group exhibited a mild trend toward reduced inflammation, the effect did not reach statistical significance.