“did not reach statistical significance”

Two studies showed a trend in cardiac [ 32 ] and all-cause (GIPS) mortality in favour of GIK, though these did not reach statistical significance.

Griffith et al, 40 who performed a meta-analysis of the effect of calcium on blood pressure, found a small statistically significant effect of calcium on lowering systolic blood pressure independent of baseline blood pressure, and a small trend toward reduction in diastolic blood pressure that did not reach statistical significance.

PET-assisted decision-making compared to standard care showed a trend but did not reach statistical significance with respect to the primary composite end point (cardiac death, myocardial infarction, or recurrent hospital admission for cardiac causes).

M402 monotherapy showed a trend towards improved survival, but did not reach statistical significance in this study (p = 0.10 by Log-Rank test).

Kaplan-Meier analysis showed a trend toward an increased OS rate for patients with hypomethylated CpG1, however, the difference did not reach statistical significance (P = 0.22, log-rank = 1.51; Figure 3 ).

In addition, Gpx2, Gpx3 , and catalase ( Cat ) all showed a trend toward higher gene expression in UCP2BKO islets, but these values did not reach statistical significance.

Patients in the upper IR tertile showed a clear trend toward higher final infarct volumes, although it did not reach statistical significance (48.1 ± 83.4 cubic centimeters in upper tertile vs. 24.83 ± 44.12 cubic centimeters in the rest of tertiles; P = 0.061).

When a subgroup of patients who stayed in the ICU for more than 5 days was analyzed, although a small trend toward mortality reduction was noted (25.5% in group 1 and 30.3% in group 2; relative reduction of 16%), this difference did not reach statistical significance.

Cavβ1b was able to significantly increase the surface pool of WT-Cav1.2-HA (10145 +/-790 ALUs, p = < 0.05 ANOVA), and there was a strong trend towards increased surface expression of A39V-Cav1.2 (10109 +/-842 ALUs), however, this effect did not reach statistical significance (also see Additional file 2 : Figure S2).

An increase of 4E-BP1 protein concentration could be due to both increased translation and transcription, as the 4E-BP1 transcript showed a trend to increase, although this did not reach statistical significance ( Fig. 3 C ).

Another clone (Clone #8) also showed a trend of higher tumor weight, although the difference did not reach statistical significance.

Although the results did not reach statistical significance by Mantel-Cox test, there is a clear trend indicating that high miR-337-3p levels and low STAT3 levels are correlated with increased overall survival.

Two RCTs found no significant difference regarding the performance of functional tasks between resurfaced and non-resurfaced patients [ 46 , 139 ], whilst two other RCTs showed a trend toward increased pain with stair ascend and descend, although values did not reach statistical significance [ 25 , 156 ].

Results showed a trend toward decreased expression of total Akt levels and decreased Akt phosphorylation in the SHR alone and SHR+D groups yet did not reach statistical significance in either group ( Figure 7C,D ).

Thus, although there was a small trend toward increased CD8 T cell infiltration in a peritumoral (‘stalled’) pattern in re-excision samples, this trend did not reach statistical significance.

At 3 months there was a clear trend towards a decrease in pain during activity (-3 mm vs placebo) observed in all three studies although this effect did not reach statistical significance (Fig. 4 ).

DN-SCP-MCMV-infected mice treated with IL-18BP alone also succumbed by day 10, but although it did not reach statistical significance, a slight trend toward a better survival up to day 12 was nevertheless observed when the mice received a combination of DOX and IL-18BP (Figure 4 A).

SNR patterns changes on MPEP+CD did not reach statistical significance, but showed a trend toward increased burstiness, but not as pronounced as LD+CD.

Although the differences in triglyceride concentrations did not reach statistical significance, there was a statistical trend for increased triglyceride concentration in the obese group (Table 1 ).

EA-ONCE/1 (Electroacupuncture Administered Once at PID 1) While EA treatment given only once at PID 1 showed a trend towards reducing tumor-associated nociception when compared to the tumor-no EA groups, this did not reach statistical significance in either male or female animals at any of the time points tested ( Figure 3(a) ).

After controlling for FIGO stage, the presence of LVSI showed a trend toward worse overall survival although it did not reach statistical significance (HR: 2.16, 95% CI: 0.85–5.45, P = 0.10).

The log-rank test showed a trend towards better overall survival in the high-Bmi-1 group, but it did not reach statistical significance ( p = 0.13, Figure 4A ).

In non-drinking subjects, diabetic blood parameters such as HOMA-B, HOMA-S and FBG showed an increasing trend according to serum GGT level, but did not reach statistical significance.

In order to test whether this was a reflection of a general increase in histone density, we further examined the density of histone H2B but did not find a reproducible increase in the RTT patient samples on any loci, and a slight trend toward higher histone H2B occupancy did not reach statistical significance ( Fig. 3B ).

Interestingly, the inverse correlation observed for bCSp did not reach statistical significance (2A) when epitope-conservation was defined as mCSp (r = −0.40, p = 0.139, Figure 6A ), although the data showed a trend in the same direction as was observed for the bCSp analysis.