Profile-profile comparisons using an alignment of the Het-C domain (Figure 8 E) revealed hits with borderline significance (p = .001; 50% probability) to a group of α-helical hydrolases sharing a common a fold, including zinc-dependent phospholipase C [ 131 ] and the S1-P1 nucleases [ 132 ].
The DSS of RCC patients showed significance and borderline significance (-T3: P <0.001 and -T6: P =0.06, respectively) in the former (i) classification approach, but not in the latter (ii) P =0.3, indicating that there were complementary, but not competitive, correlations between GalNAc-T3 and -T6.
In the subgroup with a follow-up date of more than four years, patients with hypothyroidism can reduce the risk of breast cancer, with borderline significance (OR 0.96, 95% CI 0.91–1.00, P < 0.001).
In univariate analysis, multiple USG findings showed significant association with cancellation: large ovarian/uterine masses (OR 17.0, 95% CI 5.3–54.5, p < 0.001), hepatomegaly (OR 38.2, 95% CI 18.9–77.1, p < 0.001), hepatic steatosis (OR 6.3, 95% CI 1.3–30.0, p = 0.008), gallstones (OR 5.3, 95% CI 1.8–12.9, p = 0.002), and choledochal cyst (OR 29.7, 95% CI 2.3–Not estimable, p = 0.041), while suspected lymphoma ( p = 0.051) showed borderline significance. large ovarian/uterine masses remained significant (adjusted OR 12.9, 95% CI 3.0–55.2, p = 0.001), while bladder polypoid lesion (OR 12.4, 95% CI 0.7–220.1, p = 0.093) and adrenal lesion > 4 cm (OR 15.8, 95% CI 0.8–312.5, p = 0.074) showed borderline associations.
Results were highly consistent with those of the chi-square analyses: participant commitment remained highly significant ( p < 0.001), frequent appointments remained significant ( p = 0.02), and language barriers showed borderline significance ( p = 0.05).
In contrast, the first-time offense rate of methamphetamine had an increasing trend (0.66 per 100,000 per year; P = 0.09, borderline significance) and that of ecstasy had a decreasing trend (− 0.77 per 100,000 per year; P = 0.001) since 2001; neither rate was influenced by the intervention.
A less restrictive attitude toward antibiotic use was negatively associated with antibiotic knowledge, while a restrictive attitude was suggestive of higher knowledge of antibiotic resistance (borderline significance, p = 0.001).
Significant differences were observed between Grade 2 and Grade 4 in VAS ( p = 0.013), ICOAP-constant pain score ( p = 0.041), ICOAP-total score ( p = 0.047), TUG ( p = 0.025), and KOS-ADLS ( p = 0.055, borderline significance), while quadriceps muscle strength of the affected knee did not reach statistical significance in this comparison ( p < 0.001 indicates strong significance depending on direction) (Table 3 ).
The specificity was higher in the weakly-supervised DL model than the fully-supervised DL model with automated ROI annotation with statistical significance or borderline significance ( P < 0.001, P = 0.07, and P = 0.04 in VGG16, ResNet34, and GoogLeNet models, respectively).
When stratified for treatment, we found that PD‐L1 + CTCs detected by IF were associated with a better PFS (HR = 0.55, 95% CI 0.28–1.08, p = 0.084, Figure 2 ) for ICI treatment in a borderline significance, but a worse PFS for other therapies (HR = 1.85, 95% CI 1.21–2.85, p < 0.001, Figure 2 ).
A1 in both macaques and humans showed robust response profiles across the 16 stimulus categories ( Figure 1 E) that correlated well across hemispheres particularly in humans and with borderline significance in macaques (human A1, left versus right, median bootstrapped Spearman’s rho = 0.708, bootstrapped p = 0.0012, below the Bonferroni-corrected threshold of p = 0.05/8 = 0.0063; macaque A1, left versus right, rho = 0.608, p = 0.007, n.s.).
We also found that RXRA , a heterodimeric partner of VDR , also showed borderline significance (Additional file 11 , p = 0.00139).
Enrichment in genes expressed in the adrenal gland for TS-ADHD-ASD was also highlighted, reaching borderline significance ( p = 1.89 × 10 −3 , with a significance threshold of p < 1.67 × 10 −3 ) ( Figures S2 and S3 in Supplement 1 ; Table S10 in Supplement 2 ).
Multivariable model showed aneurysm location and configuration have significant effect on operation time, and whether aneurysm was ruptured or not showed borderline significance (p = 0.002, p = 0.043, p = 0.064, respectively).
A borderline significance of the same compound genotype was also detected between the two control groups of EBV/IgA/VCA negative vs. positive individuals (OR = 0.25, p = 0.002).
IL-7, which had borderline significance ( p = 0.002) in the cytokine antibody array experiment, was also tested.
Among the 13 age-related metabolites found in the KORA study, 11 metabolites were well replicated in the TwinsUK sample, with P < 0.004 for the significance level after adjustment for multiple testing with the Bonferroni correction method ( Table 2 ), and the effect direction was the same as in the discovery sample (except for one metabolite, PC ae C36:1), with borderline significance in the TwinsUK sample ( P = 2.00 × 10 −03 ).
Significant differences for Design and layout of home (21% versus 8%, χ 2 = 11.44, p = 0.001) and borderline significance for Design and layout outside of home (24% versus 12%, χ 2 = 9.31, p = 0.002) were also found between groups. 4.
Although the differences in quality of life scores between the intervention and control groups only achieved borderline significance on 7 and 28 days (P=0.002 and P=0.046, respectively), both groups demonstrated a gradual improvement in quality of life (P<0.001 for both groups in trend analysis; table 2 ).
Finally, relative fat intake reached significance in the survival analysis (HR (95% CI) = 0.95 (0.93, 0.98), p = 3.46 × 10 −5 ) and borderline significance in the LMM analysis (beta(95% CI) = 0.24 (0.09, 0.39), p = 0.002).
The SAFT90 protocol showed borderline significance (pre: 7.46 ± 1.55, post: 6.53 ± 1.36; Z = 2.941, raw p = 0.003, ES = 0.50) (Fig. 7 C).
Mixed/undefined MNV type was associated with a greater risk of atrophy than type 1, with borderline significance (HR, 1.59; P = 0.003).
There was a positive correlation between updating errors and cognitive confidence at borderline significance level [ r (297) = 0.17, R 2 = 0.03, p = 0.003].
AVCMF (181/276 relapsed; control (199/263 relapsed); X2, = 11.68; P= 0.006. Prolongation of relapse-free survival was highly significant in premenopausal patients (X2i = 8.8; P = 0.003: Figure 2a) but of only borderline significance in post-menopausal patients (X21 = 3.3; P = 0.07: Figure 2b).
Maternally-derived associations of this APOB SNP with borderline significance were also seen with fasting glucose and insulin levels in the combined results (combined p-value = 4.0x10 -3 and 7.4x10 -4 for glucose and insulin respectively), whereas no associations were observed with the paternally-derived allele ( Table 1 ).