Maternally-derived associations of this APOB SNP with borderline significance were also seen with fasting glucose and insulin levels in the combined results (combined p-value = 4.0x10 -3 and 7.4x10 -4 for glucose and insulin respectively), whereas no associations were observed with the paternally-derived allele ( Table 1 ).
After adjustment for age, sex, smoking status, diabetes, hypertension, and dyslipidemia, these associations were still highly significant for ischemic heart failure (OR = 0.74; 95% CI = 0.60–0.91, P = 0.005) and retained borderline significance for nonischemic heart failure (OR = 0.80; 95% CI = 0.61–1.00, P = 0.050). 3.3.
Reported confidence in this skill increased over time, reaching borderline significance when corrected for multiple comparisons ( t (79) = 2.87, p = 0.005).
While the isoform-specific transcripts dominate the multivariable model and remain highly significant ( P < 0.005), the summarized genes do not dominate clinicopathological variables and as a result have a borderline significance for predicting BCR ( P = 0.05).
Indeed, the overall effect of fenofibrate in the presence of marked dyslipidemia was larger than that in all other groups, with borderline significance of treatment by group interaction: marked dyslipidemia group: 27% risk reduction (adjusted HR 0.73 [95% CI 0.58–0.91], P = 0.005); all others: 6% risk reduction (0.94 [0.83–1.06], P = 0.321; P interaction = 0.053) ( Fig. 2 ).
miR-98 or miR-148b-3p itself shows a significant survival difference between high and low expression (pvalue < 0.0077 and pvalue < 0.0014), while miR-124-3p with 979 targets genes shows a borderline significance (pvalue < 0.0051).
We found that five of the six recurrent chromatin regulatory genes described above (Table 1 ; not EP400 ) contributed to findings for the Constrained Genes set with borderline significance ( n = 968; Fig. 2 , panel 1, P = 5.28 × 10 −3 ).
A borderline significance ( p = 0.0053) of age was found on the SMQ school subscale, with no age effect on the other two subscales measuring speech behaviour at home and in public ( p > 0.62).
The TLICS scores of injury morphology and PLC integrity were significant different between patients who received non-operative or operative management by all six radiologists during the first and second reviews ( p < 0.000), except for the injury morphology score during the second review by one radiologist with borderline significance ( p = 0.006).
CERAD Delayed Recall maintained borderline significance across models (Model 1: +0.45, P = 0.006; Model 2: +0.41, P = 0.017; Model 3: +0.37, P = 0.035).
Results The Pearson test has showed a statistically significant correlation between Vol breast and V10, V20, V30 with borderline significance (p = 0.006; p = 0.02; p = 0.05).
Notably, PCS score showed borderline significance (Coefficien t = -0.043, P= 0.006, O R= 0.958) in influencing treatment efficacy. 4 Discussion In the emerging field of occupational health, particularly within high-stress professions, the intersection of sleep quality and EI presents a fascinating and critical area of study for investigation.
Quantitative western blot also showed that WS635 mitigated the anesthesia/surgery-induced reductions in synaptophysin amounts in the hippocampus ( P = 0.091, borderline significance, Figures 6E,F ) and cortex ( P = 0.007, Figures 6G,H ).
HALP showed only borderline significance. According to the multivariate Cox regression model, male gender (HR: 2.024; 95% CI: 1.215–3.373; p = 0.007), elevated LAR (HR: 5.271; 95% CI: 2.611–10.641; p < 0.01), and the presence of concomitant bone metastasis (HR: 2.355; 95% CI: 1.262–4.393; p = 0.007) were identified as independent predictors for bone marrow metastasis ( Table 7 ).
The median ‘regional’ tau load in the caudate (PSP-CBS: 0.14; PSP-RS: 0.49; P < 0.001), STN (PSP-CBS: 0.21; PSP-RS: 0.40; P < 0.001) and cerebellar white matter (PSP-CBS: 0.02; PSP-RS: 0.06; P = 0.007 with borderline significance) was greater in the PSP-RS than in PSP-CBS (Figures 1 and 2 ).
Further multivariate analysis found that DM (hazard ratio [HR], 2.68; 95% CI, 1.10 to 6.54; p=0.051 [borderline significance]) ( Fig. 1A ), age (HR, 2.82; 95% CI, 1.47 to 5.40; p=0.007), histology (HR, 6.61; 95% CI, 2.44 to 17.94; p=0.006), and DSI (HR, 2.53; 95% CI, 1.32 to 4.87; p=0.007) were independent adverse prognostic factors for RFS ( Table 4 ).
A correlation between the in vitro culture and ex vivo proteomic levels was only seen for CCL5, CFD, and cystatin C/CST3; a highly significant correlation was seen for cystatin C/CST3 ( p = 0.0078, r = 0.65) whereas only borderline significance was reached for CCL5 ( p = 0.048, r = 0.79) and CFD ( p = 0.055, r = 0.55).
2 C, D) could not be validated as a significant prognostic factor for LRC, while the total volume of primary tumour and lymph nodes showed borderline significance for LRC in the validation set (t: HR = 1.57, p = 0.008; v: HR = 1.61, p = 0.050).
Baseline CA showed borderline significance (β = 0.059, P = 0.008), suggesting a positive influence on astigmatism progression.
1B ) showed the mean CSF IL-6 level in patients with NBD was 23.0 ± 59.0 pg/ml (median, 1.1 pg/ml), which was higher than that of healthy controls with a borderline significance ( P = 0.008).
The correlation between dietary fat percentage and GGT levels in RC/CC premenopausal women showed borderline significance ( P = 0.008) and was also tested for interactions.
The overall estimate of effect size for WOMAC favoured the cell therapy group, although it reached only borderline significance levels in the presence of a huge degree of statistical heterogeneity (I 2 = 85%, p = 0.009, chi-squared test) (MD = −7.15, 95% CI = -14.52 to 0.02, Z = 1.90, p = 0.06, chi-squared test) (Supplementary Figure c).
Compared with Group 1, the levels of epithelial cell desquamation and ciliary loss were reduced, and the extent of healing of degenerated areas increased, with borderline significance ( p = 0.009).
Although this association only achieved borderline significance, there was a highly significant genotype by diabetes interaction (p = 0.009).
In addition to the 11 significant female-biased pathways, we identified two male-biased pathways with borderline significance: pathways related to programmed cell death protein 1 (PD-1), programmed cell death-ligand1 (PD-L1) cancer immunotherapy (z-score = − 0.82, -log( p ) = 2.01) and p53 signaling (z-score = − 0.45, -log( p ) = 1.64).