“borderline significance”

Birth spacing observation In one study a trend towards a lower prevalence of doctor diagnosed hay fever was observed with closer birth spacing, but this was of only borderline significance (0 05 < p < 0 1) after adjustment for other factors ( 22 ).

Several additional C2H2 zinc finger protein binding sites were discovered with borderline significance ( P = 10 –42 ) for transcription factor proteins ZKSCAN1, ZNF467, and ZNF165.

An example is apolipoprotein B ( APOB ) – E05 thyrotoxicosis (hyperthyroidism) association which achieved P = 9.02 × 10 −9 in pan-ancestry analysis but had borderline significance ( P = 1.77 × 10 −8 ) in EUR-specific analysis.

To the best of our knowledge, significant genome wide association for four of these loci are unreported in the context of de novo tinnitus (represented by rs7336872, rs115125870, rs1532898 and rs2537), with rs7336872 showing borderline significance in the study by Wells et al. 14 ( p = 5.9 × 10 –8 ).

Genome-wide significance is generally considered any SNP with a p value less than 5 × 10 −8 ; however, SNPs reaching borderline significance, p < 10 −7 , will also be extracted as borderline significance has been found to be generally replicable [ 17 ].

Variants within LIPC (lipase hepatic, 15q21-q23) associated with HDLC-GLUC, ( rs2043085 , P = 1.3E-08) and with WC-HDLC ( rs10468017 , P = 5.5E-08); ABCB11 (ATP-binding cassette, subfamily B [MDR/TAP], member 11, 2q24) associated with HDLC-GLUC ( rs569805 , P = 8.5E-08); TRIB1 (tribbles homolog 1 [ Drosophila ], 8q24.13) variants were associated, respectively, with HDLC-TG ( rs2954026 , P = 7.9E-09) and TG-BP ( rs2954033 , P = 8.5E-09); and TFAP2B (transcription factor AP-2 β [activating enhancer binding protein 2 β], 6p12) was associated at a borderline significance level with WC-GLUC ( rs2206277 , P = 1.3E-07).

We replicated 19 loci at the genome-wide significance level and seven at borderline significance level ( P < 10 −6 ).

Borderline significance (5 × 10 −8 < p < 1 × 10 −6 ) for association with systolic BP was achieved for four index SNPs at four separate loci; there were four SNPs showing borderline significant associations with diastolic BP at four separate loci.

As noted in Table 3 , rs7130284 does not show compelling evidence for association with Hcy in the AA participants included in our meta-analysis (β= −0.069, p=0.023) but the rs11018628 variant reported in WGHS approached borderline significance (β= −0.14, p=2.0 × 10 −6 ).

One site has borderline significance in both the differential methylation analyses of SEL (−log10(p) = 5.36 and the differential methylation analyses of F2C (−log10(p) = 7.24).

Since the sample size of personality was not large enough, to get more SNPs, all the exposed genetic IVs were identified at least borderline significance ( p < 5 × 10 −6 ) 25 , and clumped at the threshold of linkage disequilibrium (LD) ( r 2 < 0.001 within 10,000 kb).

Moreover, Jmjd1a , a histone 3 lysine 9 (H3K9)-specific demethylase that binds all 3 myocardin family members, was positively correlated with A velocity at week 3 with borderline significance ( r = 0.457, p = 7.69e−06, BH adjusted p = 0.0549) and is known to be upregulated in myocardium from patients with hypertrophic heart disease ( 21 ).

For the third most significant genotyped loci, located on chromosome 8 in the vicinity of the ZNF704 gene, borderline significance was achieved ( P <10 −5 ).

In a meta‐analysis of six studies of CRT, the 95% CIs for the improvement in peak VO 2 with CRT went from 0.32 to 3.22 mL/kg/min, with borderline significance, P = 0.017, 35 compared with the narrower CI, and more highly significant effect seen here: 95% CIs for the improvement in peak VO 2 with CCM between 0.56 and 1.30 mL/kg/min, P < 0.00001, giving a considerably more precise estimate of efficacy and of increased statistical significance.

The loci 25,684,587–26,791,233 in the same chromosome showed borderline significance ( p = 3.16x −5 ), however, this significance did not survive the Bonferroni correction (Table 2 ).

A total of 1,313 SNPs demonstrated borderline significance ( P < 5*10 −5 ).

In contrast, rs4304220 on chromosome 7 (6,243 SNPs) showed borderline significance: it was significant for RSB ( RSB =3.55, -Log 10 P -value=3.71) and near-significant for XP-EHH ( XP-EHH =1.33, -Log 10 P -value=1.04), also with positive values pointing to recent positive selection in the HC group ( Fig. 3 B).

After PSM, the incidence density of dementia (HR, 1.57; 95% CI, 1.00–2.45; P = 0.0501) was higher with borderline significance in patients with AF than in patients with AFL, and the incidence density of ischemic stroke (HR, 2.54; 95% CI, 1.56–4.12; P = 0.0002) was significantly higher in patients with AF than in patients with AFL (Supplemental Table 5).

Among them, rs1408705 (with borderline significance, p = 0.00024) is located in PACRG (PARK2 co-regulated), which was previously found to be deleted in clear-cell renal cell carcinomas [ 38 ].

In the northern Finnish population, there was a SNP–SNP interaction that showed borderline significance for risk of moderate-to-severe BPD; this interaction was between IL6ST rs10471960 and IL10 rs3024493 SNPs ( P =0.0003, OR interaction =35.4; Table 4 ).

Only 17 SNPs within DRD1 , DRD2 or TH have shown borderline significance (1 × 10 –4 < p < 5 × 10 –4 ) in association with RLS (see Additional file 5 ).

Although amikacin and teicoplanin use were found to be highly significant in the univariable analysis ( P < .001), in the multivariable model, after adjusting for risk factors and other confounders, the association between amikacin and teicoplanin with the primary outcome attenuated showing only borderline significance ( P = .04 and P = .04, respectively).

The DSS of RCC patients showed significance and borderline significance (-T3: P <0.001 and -T6: P =0.06, respectively) in the former (i) classification approach, but not in the latter (ii) P =0.3, indicating that there were complementary, but not competitive, correlations between GalNAc-T3 and -T6.

Neutrophil-mediated immunity showed borderline significance (GO:0002446; P = 0.001; adjusted FDR Q = 0.059; related genes were LGALS3, ARSA, SERPINA3, GRN, GSN, JUP, GAA, PSAP, CAT, CTSH, CTSD, and DNASE1L1).

The specificity was higher in the weakly-supervised DL model than the fully-supervised DL model with automated ROI annotation with statistical significance or borderline significance ( P < 0.001, P = 0.07, and P = 0.04 in VGG16, ResNet34, and GoogLeNet models, respectively).