“an unfavorable trend”

This mutation exhibited an unfavorable trend in terms of survival (HR 7.775; P < 0.001), indicating a potentially detrimental effect on patient outcomes [ 190 ].

As shown in Supplementary Figure 2 , high scores for cluster_2 and cluster_3 were significantly associated with poorer survival outcomes (p < 0.001 and p = 0.005, respectively), while cluster_0 also demonstrated an unfavorable trend (p = 0.0031), highlighting their potential prognostic relevance. 3.4 Reconstruction of malignant epithelial cell differentiation trajectory To further investigate the transcriptional heterogeneity and differentiation dynamics of malignant epithelial cells, a pseudotime trajectory analysis was conducted.

Survival analysis demonstrated that patients in the high Met-Index group had significantly shorter overall survival (OS, log-rank p = 0.005) and also exhibited an unfavorable trend for progression-free survival (PFS, log-rank p = 0.015) compared with those in the low Met-Index group (Fig. 5 B, top).

The administration of adjuvant chemotherapy was associated with worse PFS ( p = 0.013), and an unfavorable trend was also observed for DM incidence ( p = 0.055).

Compared with one tumor lesion, two lesions were significant unfavorable prognosticator of OS (HR, 3.148; 95% CI, 1.747–5.672; p < 0.001), three lesions also showed an unfavorable trend albeit without statistical significance (HR, 2.116; 95% CI, 0.967–4.633; p = 0.061).

The overall survival rate of d-GC patients showed an unfavorable trend compared to that of i-GC patients ( P = 0.072).

The intention-to-treat analysis demonstrated a favorable trend with high-dose edoxaban (1.57% high-dose edoxaban versus 1.8% warfarin; p = 0.08) and an unfavorable trend with low-dose edoxaban (2.04% low-dose edoxaban; p = 0.10).

Although pCR rates were consistent with our current results, this study showed an unfavorable trend for CROSS compared to PF (MST 32.7 versus 16.7 months, respectively, p = 0.083).

3 , violet boxes) showed an unfavorable trend in the Southern (39% (32/82) versus 36% (20/56) in the Centre and 32% (49/151) in the Northern) (overall p = 0.098).

In the intention-to-treat analysis, there was a trend favoring edoxaban 60 mg versus warfarin (HR: 0.87 (97.5% CI: 0.73–1.04); P = 0.08) and an unfavorable trend with edoxaban 30 mg versus warfarin (HR: 1.13 (97.5% CI: 0.96–1.34); P = 0.10).

In the intention-to-treat analysis, there was a trend favoring E60 versus warfarin (HR, 0.87; 97.5% CI, 0.73 to 1.04; p=0.08) and an unfavorable trend with E30 versus warfarin (HR, 1.13; 97.5% CI, 0.96 to 1.34; p=0.10).

5 A, for the subgroup including patients with less than 15 ml of hematoma volume, in terms of 90-day renal insufficiency, intensive antihypertensive treatment showed an unfavorable trend compared with conventional antihypertensive treatment (RR = 2.00, 95% CI = 0.50–7.95, P = 0.33).

The health sector, for instance, appears to be experiencing an unfavorable trend, a situation that has likely been exacerbated by the pandemic.

There was a favorable trend of clinical improvement and mortality in patients on mechanical ventilation, but also an unfavorable trend in non-mechanically ventilated subjects ( Sanofi, 2020 ).

In many psychopathological domains, moderation analysis showed an unfavorable trend over time for younger participants.

In this study, we observed an unfavorable trend in overall dietary quality and dietary intakes of fresh fruits, fresh vegetables, whole grains, dietary fiber, SSBs, and saturated fat in 2013–2022.

No significance was found analyzing the prognosis in pediatric patients according to the expression level of B7-H3, CD47, or TILs/TAMs, though an unfavorable trend was observed in the group with high expression of B7-H3 compared to the one with low expression ( Figures 4C–F ).

The reduced Young’s Modulus may indicate a ,,pseudo-plastic effect” for ceramic-polymer cements, while the compressive strength after modification showed an unfavorable trend.

In Brazil, data from the Food and Nutrition Surveillance System (SISVAN in Portuguese) indicate an unfavorable trend toward obesity in Brazilian children between 5 and 10 years old, with a prevalence of 10.45% and 16.96% in a temporal variation between 2008 and 2021, respectively ( 3 ).

Unfortunately, the literature on poultry diseases shows an unfavorable trend of confusing the metabolic diseases osteoporosis and osteomalacia because many experiments lack the inclusion of techniques able to truly differentiate these conditions, such as histopathology and bone mineral analysis.

We found that patients who showed an unfavorable trend of mutation abundances of KRAS, TP53, and/or CDKN2A at the second or third measurement mostly experienced PD within 4 months of chemotherapy.

47 , 48 However, this study also found an unfavorable trend in the mortality of liver disease due to hepatitis B in women of childbearing age in Australasia, Eastern Europe, and High-income North America between 1990 and 2021.

Abstract Background An unfavorable trend of increasing rates of colorectal cancer has been observed across modern societies.

There was an unfavorable trend regarding the 90-day outcomes for the over-80 patients treated for atrial fibrillation compared to patients of the same age group without atrial fibrillation.

Although all countries (except Monaco) decreased their aPM 2.5 level in 2019 compared to 1990, 31 of 43 European countries had a negative PMR change and an unfavorable trend of increasing PMR in 2019 compared to 1990, thus not reducing its aPM 2.5 concentration to at least the extent of decrease in the European median.