“an overall trend”

There was an overall trend for increase in anti-RR titer during the therapy ( Figure 5B and C ), but there was considerable heterogeneity in the tempo and steadiness of anti-RR titer among different patients.

57 Contrarily, although the point estimates for the other obese groups were also in the same direction, raising the possibility that this an overall trend to greater survival with progressively increasing BMI, our study found that survival time up to 2 years was independently associated only for patients with BMI ≥40 kg/m2.

As an overall trend, the degree of shrinkage of the mixed monolayer and the thermodynamic favorability of mixing were greater in the DPPC–DPCB combination than in the DPPC–DPSB combination.

An overall trend of performance improvement with increasing audibility can be observed.

Nevertheless, evidence exists for variation across childhood and adolescence, with an overall trend of decreased inflammatory agalactosylation with increasing age ( 372 , 373 , 376 – 378 ).

7 , 26 Use of OSS seems to be an overall effective and safe method for full-thickness closure of defects after ESD with an overall trend toward shorter intervention time as users become more familiar with the device. 7 However, the downsides to use of OSS include limited maneuverability, cumbersome operation, and possible equipment malfunction while in use.

Interestingly, two different models of unpredictable chronic mild stress and Flinders Sensitive Line all showed decreases in 2-AG in the hippocampus ( 19 , 32 , 33 ), suggesting an overall trend toward decreased 2-AG in rodent models of depression. 2-AG is largely understudied in epilepsy, with one study of absence seizures in Genetic Absence Epilepsy Rat from Strasbourg (GAERS) reporting an increase in 2-AG ( 34 ) and another study in patients with MTLE reporting a decrease ( 27 ).

Furthermore, whereas the association with EPCR rs2069948 was restricted to patients with ER and PR positive tumors (OR 1.27, 95% CI 1.01-1.58; and OR 1.30, 95% CI 1.03-1.65, respectively), there was an overall trend that the four SNPs in F5 were confined to hormone receptor negative patients (ER/PR negative) (ORs from 1.54 to 1.99) and triple negative patients (ER/PR/HER2 negative) (ORs from 1.68 to 2.11) when compared with healthy controls (Additional file 3 : Table S2).

Although the levels of the transcriptional regulator 7SK RNA after the p.Cys767Phe mutation were not significantly different from those of the wild type group, there was an overall trend of increased levels of 7SK RNA compared to the control group.

As SIRI values increased, there was an overall trend of rising risk for all-cause mortality.

First, the gap in reproductive patterns between women of lower SES and those of higher SES is decreasing due to an overall trend toward low birth rates worldwide.

There is however an overall trend of all helminths for losing auxiliary metabolism such as synthesis of co-factors and vitamins, and the peroxisome organelle.

Both total cholesterol and triglycerides showed an association with time since smoking cessation ( p = 0.03 for both) and an overall trend from current to never smokers in fully adjusted models.

Regarding the response to CCh, opposite to what we expected, we found an overall trend toward a smaller response of Ts65Dn versus control euploid mice.

It is evident from the overview provided in Table 4 that, while each of the case studies analysed for this research varied in the extent to which it focused on equity, there was an overall trend away from an equity focus and towards a predominant focus on intersectoral collaboration.

Species in tropical and subtropical regions showed an overall trend of higher likelihood for hosting flaviviruses due to which hotspots of higher host richness for JEV, DENV, ZIKV, YFV, and for bat-specific flaviviruses were seen across tropical regions of Southeast Asia, South America and Africa.

Epidemiology – time trends We found PPE frequencies from 30 cases (2004–2008) to a maximum of 43 cases (2012–2016) per 4 years, with an overall trend of increasing frequencies.

Research on precipitation changes across the QTP have revealed that annual average precipitation increased at a rate of 2.54 mm per decade from 1982 to 2000, indicating an overall trend toward a wetter climate ( Zhong et al., 2011 ; Yang et al., 2014 ).

Encouragingly, in our study, there has been an overall trend toward improved survival (56.7 to 62.8%; Supplementary Table 4 ) over the last 5 years.

An overall trend when comparing design features was that healthcare professionals rated every feature as more important than did wheelchair users, with the exception of the ability to walk without arm crutches.

Meanwhile, the study found fluctuations in the scores of all topics around 0.8, suggesting a considerable number of comments with a positive attitude toward gamified education, and an overall trend of positive sentiment.

Figure 3 shows that recipients with biochemical evidence of recurrence had an overall trend toward worse combined graft loss and death probability than those without any sign of recurrence of LN.

Deep sequencing analysis from the clindamycin selection reveals a densely connected network of winning genotypes, which display an overall trend of positive epistasis, suggesting the importance of epistatic interactions in evolving ribosome function.

A ratio was measured to correct for an overall trend.

Only three participants completed the intervention program, pre- and post-intervention assessments: two reported improvements in total MQOL scores, yet all three shared an overall trend towards worsening symptom and total fatigue scores post-intervention.