However, male Nrf2 KO mice had a 2-fold increase ( p < 0.05) in average tumor burden (4.05 ± 0.6 mm 3 in males compared to 1.9 ± 0.3 mm 3 in females) and an overall trend toward increased severity in tumor histopathology compared to female Nrf2 KO mice ( Table S3 ).
However, the results may reflect an overall trend in the lineages of S. pneumoniae in Colombia.
We measured an overall trend of reduced viral RNA in repNP-vaccinated animals with significantly reduced viral RNA in the liver and inguinal lymph nodes ( Fig. 5 g) compared to sham-vaccinated animals.
3 a, 3c, and 3e, the number of newly infected individuals showed an overall trend of first increasing and then decreasing.
Obtained results showed an overall trend towards a reduced heat tolerance with progressing phenology, as mean T PCD50 values of swollen buds were generally lower (except for P. abies ) than those of closed buds (Figure 1 , Table S1 ).
Although there was an overall trend towards higher thresholds at 4 kHz, in individual participants this dip was too shallow to be defined as a noise-induced (notched) hearing loss ( McBride and Williams, 2001 ).
In addition, although we also measured the mRNA expression levels of pro-inflammatory cytokines in adipose tissues and the liver, the observed results showing the inflammatory state in the tissues did not indicate an overall trend of change in a certain direction ( S1 Fig ).
There was also an overall trend towards hypomethylation ( Fig 1B ).
Risk level transitions showed an overall trend of risk reduction: 60.5% of high-risk cases improved, and 51.8% of low-risk cases transitioned to no risk.
There appears to be an overall trend in the number of articles published per year ( Figure 1 ), with noticeable spikes in 2001 and 2006.
Both cases show an overall trend of a decrease in the order parameter as the cutoff radius is increased, with the order parameter being consistently lower in the cross-linking case than without cross-linking.
On the right, the CCS among residues is shown, which followed an overall trend of normal distribution, except that the CCS was small.
Using case reports submitted to the respective state health departments over the years we asked the following specific questions; Is there an overall trend (increase, decrease or stable) for RMSF in the region comprising these four states?
For both post-distalization and post-treatment records, the included studies demonstrate an overall trend of an increase in the mandibular plane angle.
However, we observed an overall trend in reduction of CE content upon SQS degradation compared to cells treated with DMSO or compound 18 by about 40%.
As an overall trend, HRV increased with the number of tests.
This result suggests that the frequency of visiting green areas among Group 1 respondents was more influenced by the pandemic than that among the other groups’ respondents; it also suggests that, as an overall trend, the frequency of visits among the respondents in Group 1 rose even higher, despite official discouragement with regard to going out and visiting places during the emergency period. 4.
There appeared to be variability between cell lines and treatments ( Figure S3 ); however, an overall trend across cell lines was the predominant upregulation of genes within 24 h after treatment, especially in RT- and TMZ + RT-treated cells ( Figure 5 A).
As can be seen from the figure, with the increase of tempering temperature, the reversed austenite content in the sample steel shows an overall trend of first increasing and then decreasing, and it reaches a maximum value of 7.1% at 560 °C.
Although they confirmed an overall trend towards vertical steepening and WTR astigmatism, they identified 3 subgroups characterised by 1) superior corneal steepening, 2) superior corneal flattening, and 3) irregular changes.
Despite an overall trend of increasing numbers of manuscripts focussing on ED within the top 100 during this period, the relative proportion of manuscripts fell with each decade (66.7, 47.1 and 46.3% between 1980 and 89, 1990–99 and 2000–09 respectivelty).
While the manuscript addresses some relevant literature, there is an overall trend towards selectiveness and to superficially discuss theoretical models and approaches.
An overall trend was visible that both fungi promoted an increase in biomasses (Figure 2 ).
PROs by clinical outcomes When mean change from baseline to week 26 in TRIM‐D total scores was assessed according to change in HbA1c, change in body weight, hypoglycaemia incidence and reaching the composite target (HbA1c < 7% with no weight gain and no hypoglycaemia [<3.9 mmol/L, <70 mg/dl]) (Figure 4 ), there was an overall trend of a greater difference from baseline in TRIM‐D scores in participants receiving iGlarLixi compared with those receiving BIAsp 30 across all subgroups.
As SIRI values increased, there was an overall trend of rising risk for all-cause mortality.