“an overall trend”

There was an overall trend towards normalization of the initial protein alterations during treatment, although only 22 (7.5%) of the 293 diabetes-associated proteins reached statistical significance for change from baseline.

In leaves of plants at different growth stages, all showed an overall trend of first increasing and then decreasing, and they were all at their highest in 2-year-old leaves ( Figure 6 b).

Figure 5(a) specifically looks at the silicon release from the different compositions; all MBG tested show an overall trend of increasing Si release over time as the glass degrades in SBF.

Even though long-term data are somewhat limited, a few studies reveal an overall trend towards weight regain after the IGB removal [ 20 , 21 ].

Although showing an overall trend of relationship with glucose metabolism, the main effect of APOE ɛ 4 after controlling for SVD-based Aβ only appeared to be statistically significant in small regions corresponding to inferior frontal gyrus ( Fig. 2 A).

The three stains showed an overall trend of increased amounts of newly formed bone in the composite scaffolds in each group, but significant differences between groups remained (Fig. 6 ).

Since 2007, there has been an overall trend towards declining malaria cases, with a small rebound in 2012 when the SPR was 3.9% ( Fig 2 ).

When an overall trend is demonstrated, two subsequent one-sided comparisons will be performed using the regular log-rank test.

The Gini coefficient of economic resilience in the western region exhibits a fluctuation trend similar to that of the whole country, with an overall trend of growth and further expansion of regional differences in economic resilience.

From the figure, it can be seen that the regional vulnerability shows an overall trend of decreasing from east to west and from the coast to inland.

Our work does not rule out a trend of increased intrinsic specificity over deep evolutionary time, but it does caution against interpreting changes in biological specificity as evidence for an overall trend.

The grade structure of CEA changed substantially: the proportions of low-grade and moderately low-grade provinces decreased significantly, whereas medium-grade, moderately high-grade, and high-grade provinces increased significantly, presenting an overall trend of transitioning to higher grades.

As in previous studies [ 1 , 3 , 4 , 9 ], there was an overall trend for the risk of calluses, capped hock and limb wounds to increase as the proportion of slatted floor in the farrowing crate increased and the quantity of bedding decreased.

As SIRI values increased, there was an overall trend of rising risk for all-cause mortality.

In this study, it was found that, except CK, the content of ABA in alfalfa leaves under PEG stress showed an overall trend of increase, and reached the maximum on the 8th day (Fig. 2 A).

Similarly, an overall trend of increased ALT was observed throughout the time course ( Figure 4 B).

Additionally, a weak to moderate trend for increased general use of the site was also noted, with an overall trend to approximately double over 12 months when time points reflecting “live” CPD assessments were excluded ( Figure 2 B).

12 ) is dominated by cross-province flow, having the characteristics of “Hubei → Shandong” intensive flow, and “other places → Shandong” dispersive flow, with an overall trend of “southwest-northeast” mobility.

Gustatory dysfunction is significantly linked to a higher risk, 17 while olfactory dysfunction showed an overall trend and was significant in women.

While malaria incidence showed an overall trend of decline over the last decade in Banmauk, the 2017 malaria incidence almost doubled that of 2016.

elata shows an overall trend of expansion.

An overall trend of increase in net contact resulting in reduced knockdown was found ( Fig. 8 A), which links to previous results for movement ( Fig. 6 A) where more movement resulted in more knockdown, all of which were significantly different ( P < 0.001 for all net combinations).

Moreover, the increased spending among chronic pain patients using cannabis, which we note in our study, may largely be due to an overall trend of increased hospital spending.

However, there was evidence of an overall trend of fewer adaptive mutations in the harsh condition (Tables 2 and 3 ), suggesting that the lower levels of CI in the harsh environment may have been due to the lower number of available adaptive solutions, which would increase the waiting time for beneficial mutations and decrease their co-occurrence [ 3 , 12 , 16 , 17 ].

Only three participants completed the intervention program, pre- and post-intervention assessments: two reported improvements in total MQOL scores, yet all three shared an overall trend towards worsening symptom and total fatigue scores post-intervention.