“a possible trend”

We also found that the G allele of rs1966265 had a possible trend of a correlation with lymph node metastasis in the breast cancer patients.

We also found that the G allele of rs11064 had a possible trend of correlation with advanced FIGO stage, deep myometrial invasion, and lymph node metastasis in EC patients.

It should be noted that the results of this comparison can only indicate a possible trend, as the number of samples for the porcine tissue was too small.

Although there was a possible trend toward a higher rate of grade 3 or 4 hypertension in the matching-adjusted cabozantinib population compared with the regorafenib population, the confidence intervals for the estimate crossed zero (indicating no difference), and a test of the null hypothesis confirmed that the difference was not statistically significant ( p = 0.0611) (Fig. 4 and Supplemental Table S6).

Although the difference did not reach statistical significance ( p -value = 0.13), it suggests a possible trend toward a greater biomarker response in patients who tolerated up-titration.

Therefore, this result should be interpreted cautiously and regarded as a possible trend rather than definitive evidence of antagonism.

We note this particularly as our review has highlighted a possible trend towards the absence of rigorous statistical phylogeographic analyses in current studies of Antarctic biota.

Although our data show a possible trend in some such cases, the results did not reach significance.

A possible trend toward reduced FA-effect at the end of the study period should motivate a more thorough study of whether the effects are retained in later years, examining the mediators and moderators of importance for achieving an maintaining the effects that FA services seem to have the potential to create on maternal and fetal health across pregnancy and birth.

10 , 24 , 28 – 30 Results from the TRITON-TIMI 38 trial suggested a possible trend toward a reduced efficacy benefit with prasugrel versus clopidogrel in women (relative risk reduction [RRR] in the primary efficacy end point: males 21% versus females 12%). 11 However, there was no indication from the published paper that this difference was statistically significant.

We observed a possible trend towards patients younger than 30 years-old showing BRAF WT tumors.

This finding should be interpreted as a possible trend rather than definitive evidence of functional adaptation (Fig. 2 ).

Our sensitivity analyses on the NCCP subgroup showed a possible trend for higher reassurance in the Discussion arm (Additional file 6 ) but these differences were smaller than seen in the NZ study and not sustained at 6 months, and not considered to be clinically relevant.

A possible trend towards increasing localization to the lipid region with increasing depth into SC is apparent for caffeine, but the significance of this trend is unclear.

The overall proportion of IgG positive individuals was 9.8%, without any significant difference between age groups ( Figure 2b ) or even any sign evocative of a possible trend.

For a more detailed investigation of a possible trend, indications and the use of alternative therapy options would have to be considered.

Captopril ranked among the top two agents for achieving appropriate MAP reduction, with borderline statistical significance - an effect suggesting a possible trend that warrants confirmation in larger studies.

Most, but not all, studies reported either a significant inverse association between education level and type 2 diabetes or a possible trend toward such an association, with odds ratios (95% CI) ranged from 0.39 (CI not reported) to 1.52 (0.91, 2.54) for the highest compared to the lowest education level ( Figure 3 and Appendices S5 and S6 in Online Supplementary Document (Online Supplementary Document) ).

Several studies found a positive but nonsignificant correlation between the serum level of visfatin and BMI, revealing a possible trend of higher serum lipid levels in psoriasis patients with greater BMI values (BMI ≥ 25 kg/m 2 ). 18 , 23 , 26 Likewise, multiple studies ( Table 1 ) have demonstrated that serum visfatin levels were significantly positively correlated with the severity of psoriasis.

Studies on the immune response to other coronaviruses could aid in predicting a possible trend.

However, there was a near-significant effect in the requests subscale, suggesting a possible trend that could be explored with a larger sample size.

These findings suggest dimensional stability and a possible trend of increasing bone density in the collagen group over time.

To sum up, the evolving of game-based rehabilitation reveals a possible trend: more and more game-based rehabilitation systems are built using commodity hardware, such as tablets, Kinects, and Wii remotes most studies have focused on creating games from scratch, rather than adopting (already done and successful) designed-for-fun video games however, there is not enough games

Some form of oncological data has been reported only by eight studies[ 20 - 22 , 24 - 28 ] and, even though no differences have been reported in terms of disease free survival and overall survival in this systematic review, a recent meta-analysis highlighted a possible trend towards a lower 5 years overall survival for patients treated with a laparoscopic approach for ICC when compared to those operated by open approach[ 39 ].

However, the occurrence of new strokes exclusively in the MMD subgroup suggests a possible trend toward more aggressive disease in idiopathic cases, although statistical confirmation was limited by the small sample size.