However, in exploratory unadjusted analyses, HLA-B53 showed higher odds of neurological involvement when compared with children without neurological disease and healthy controls (OR = 6.29; 95% CI: 1.23–32.13; nominal p = 0.027), while HLA-B45 demonstrated a positive trend (OR = 3.75; 95% CI: 0.87–16.22; nominal p = 0.077).
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BMI showed a positive trend without reaching significance ( p = 0.077).
In PP analysis with adherence > 75%, both groups increased significantly in lumbar spine BMD with no significant treatment effect although a positive trend was seen in favor of the intervention ( P = 0.077) ( n = 13).
In cerebellum the reduction of soluble mHTT levels was less pronounced and there was more variation in the levels of the aggregated form of the mHTT protein, but nevertheless resulted in a positive trend towards reduction was observed for both mHTT protein forms after (CUG)7 administration (soluble: p = 0.077, aggregated: p = 0.066) ( S2B Fig ).
There was also a positive trend between Dicer mRNA and miR-429 (R = 0.312, P = 0.077, Table 2 ).
On adopting HOcy80 as a predictor of cumulative incidence of frailty, only a positive trend was shown (OR: 1.412; 95% CI: 0.963–2.069; p =0.077).
We then analyzed the correlation between 5hmC levels and expression of TET genes demonstrating a positive association with TET1 ( r = 0.2729, p = .0131) and also a positive trend, albeit not significant, with TET2 ( r = 0.1959, p = .0778; Supplementary Figure 1).
In PreDM, ST shows a positive trend with BMI, approaching statistical significance ( p = 0.078).
Relationship self-report craving and skin conductance level during the cue-reactivity paradigm In the smoker cohort, a positive trend was observed between the self-reported craving score and the skin conductance level ( R = 0.18, p = 0.078 ), although it did not reach statistical significance.
VTA–M1 connectivity showed a positive trend (R = 0.41, p = 0.078) that did not reach statistical significance, while VTA–SMA connectivity demonstrated no significant association (R = −0.18, p = 0.460).
As shown in Supplementary Figure 4 , the risk score was significantly positively correlated with CTLA4 (coefficient = 0.114, P = 0.029) and showed a positive trend for PD-L1 (coefficient = 0.092, P = 0.078).
Days after fever onset showed no significant effect on CD4/CD8 ratio (β = -0.34, 95% CI: -0.79 to 0.12, P = 0.144), while days of treatment showed a positive trend with CD4/CD8 ratio (β = 0.59, 95% CI: -0.07 to 1.24, P = 0.078).
Upper and lower abdominal strength ( P = 0.008 and P = 0.031, respectively) [ Figure 4 ] demonstrated significant improvement following the intervention with a positive trend in back extensor strength ( P = 0.078).
This was not identified for 2022, in which a positive trend without significance was found (r(52) = +0.24, p=0.078).
Only one cohort showed a significant result for the functional scale ( P =0.022) and a positive trend for the fatigue scale ( P =0.078) from the EORTC QLQ-C30 questionnaire [ 9 ].
Interestingly, age was not a significant measure predictive of awareness level, but a positive trend emerged where women in the age groups 45–65 were the most aware of EC symptoms among the sample population ( p = 0.078). 30% of the women in these age groups were defined as having an awareness level greater than or equal to one.
Finally, a positive trend existed between PrEP use and often contacting PE outside of scheduled visits ( p = 0.094), recent transactional sex and PrEP use ( p = 0.081), and daily users with a difficult or very difficult financial situation ( p = 0.085), while a negative trend existed between PrEP use and having had 5 + sexual intercourses with casual male partners in the previous month ( p = 0.078).
Although diet quality showed a positive trend towards higher KAP scores, the association did not reach statistical significance ( p = 0.078).
The change in HOI due to PM 2.5 showed a positive trend with particle mass concentration ( p = 0.078) and significantly associated with the slope of systolic blood pressure during exposures ( p = 0.005).
We analysed the correlation between the time during which they had been taking ocrelizumab and until they received their second dose of vaccine and the associated T cell response (Ag1 and Ag2) and did not find any significant differences, but there was a positive trend for the t correlation: R 2 = 0.8484, p value = 0.0789 for Ag1 and R 2 = 0.7875, p value = 0.1126 for Ag2.
A positive trend for pCR was shown in EGFR overexpressed BC (58% vs 28%, p = 0.079), suggesting a potential benefit of anti-EGFR therapy plus chemotherapy in this subgroup of patients. 12 Tumor-infiltrating lymphocytes Since the last decade onward, the immune system has been under investigation as a possible target in the management of different cancer subtypes.
LRP1B-mutant tumors had a significantly higher percentage of positive PD-L1 TPS vs those with wild-type LRP1B (28.6% vs 2.9%; p=0.001), and TP53-mutant tumors presented with a positive trend (12.5% vs 3.1%; p=0.079) ( figure 4A ).
Exploratory univariate analyses did not reveal any potential variable significantly associated with pain fluctuations, except for a positive trend in the association between age and pain fluctuations when used alone in the model ( p = 0.079).
Furthermore, in an analysis adjusted for sex, age and smoking habits, we observed a negative trend of association between use of Vitamin D and d-ROM (adjusted mean change − 29.7, 95% CI -62.8/+3.4, p = 0.079) and a positive trend with OSi (adjusted mean change + 0.45, 95% CI -0.06/+0.97, p = 0.084).
Male gender showed a positive trend for a better performance (p = 0.079).