A marked trend was observed when MCP-1, IL-6 and IL-10 were analyzed to describe which ones of the higher levels were associated to poorer evolution of the disease, but these differences did not achieve statistical significance ( Table 4 ).
It has been seen that the non-inoculated plants remained relatively constant throughout the test, around 3 ppm per gram of sample; the opposite occurred with the inoculated genotypes that showed a marked trend, given the significant increase in the content of total phenols.
In contrast, the number of cancer approvals did not exhibit a marked trend, respectively.
The ones related to cholesterol assimilation and antioxidant capability did not show a marked trend, and with respect to the attenuation process, the Saccharomyces yeasts were more resistant.
We observed a significant acceleration of the clinical progression in frameshift mutant TP53 gene CLL patients as compared with WTp53 CLL, while missense mutants show a marked trend of faster clinical progression as compared with WTp53 CLL (Supplementary Figure 2 ).
Those accounted for the majority of surgeries, and their increased use was observed in all age groups, with a marked trend in both pediatric and elderly populations.
In the first of these, a marked trend toward greater fracture reduction at higher baseline fracture probability was observed in a 3-year prospective, randomized, placebo-controlled trial of oral clodronate in elderly women, identified from general practice registers.
In the second, although the study was not powered enough, a marked trend towards a higher efficacy was found for combination therapy as compared to azathioprine alone [ 48 ].
A marked trend toward hypomethylation is observed for TEs located within a 1 kb distance from expressed genes, rather than segregated in TE-rich regions of the genome.
Advances in oncological treatment have made it possible to limit the extent of what represents radical surgery for breast cancer, yet in the past decade, we have seen a marked trend toward mastectomies in breast-conserving surgery-eligible patients.
Similarly, AphPHYA-B1-GFP driven by the ApuPHYA promoter ( Pro ApuPHYA-B2 ::AphPHYA-B1-GFP ) showed a marked trend toward increased submergence-induced protein accumulation compared to Pro AphPHYA-B1 ::AphPHYA-B1-GFP (Fig. 5k and Supplementary Fig. 5b, c ).
No significant correlation was observed between LI or ERD/ERS and clinical scales, but a marked trend was detected over time: changes in clinical scales, associated to a good recovery, paralleled with changes in LI values, which evidence modifications of ERD from contralesional to ipsilesional side.
In our data, we found a marked trend towards more natal females being referred over the six-year period from 2011 to 2016, with a ratio of approximately 1:2 compared with natal males requesting transition.
Diversity showed slight differences with depth but differed from the pattern exhibited in the “old” areas of the Potter Cove, and in the majority of Antarctic coastal areas, where a marked trend of diversity increment with increasing depth was reported [ 50 , 62 – 65 ].
Inhibition of CERK caused a marked trend in the increase of ceramide levels after mechanical trauma to cells in culture, but these differences were not significant suggesting either CERK activation or CPTP inhibition/downregulation is the mechanism of C1P induction.
A marked trend was seen with increasing levels of both markers of inflammation with higher POP exposure.
However, this was not observed when compared to the tumors treated with PBT+αPD1, despite a marked trend.
Those who had been discharged by the study end-date (January 2011) had a marked trend toward reduction in their Vulnerabilities score (mean = −3.9; 95% CI −7.9, +0.2) whilst those who had not been discharged at that point remained somewhat static (m = +0.1; −1.9, +2.1) but the difference in change between the discharged and in-patent groups was not significant.
However there was a marked trend for Method I to measure larger values of Y v than Method II .
For instance, the spatiotemporal variability of precipitation and temperature trends (minimum, maximum, and average) was analyzed in 47 stations in the Brazilian Amazon for the period 1973–2013, the results showed that these had an increasing trend of approximately 0.04 °C per year and precipitation did not show a marked trend [ 23 ].
In this sense, it is noteworthy that in all the categories of the variables evaluated, the percentage of negative response for the use of oral health services was higher, which indicates a marked trend in the Peruvian population, also repeated in other regions (Gao et al., 2020 ; Nazir, 2018 ; Onyejaka et al., 2016 ; Portero de la Cruz & Cebrino, 2020 ).
There was a marked trend towards lower expression of HLA-DR and HLA-A, B, and C on mDCs and pDCs of MM patients compared to HDs ( 41 ).
Hence, control flies had a marked trend to end in positive optomotor positions, whereas SoxD-RNAi flies showed no preference (Fig. 5C ).
Introduction In the contemporary global landscape, there is a marked trend toward an aging population.
Furthermore, the consistent presence of calcium oxalate in the analyzed stones corroborates the urine metabolic data, emphasizing a marked trend towards calcium oxalate supersaturation [ 4 , 13 , 43 ].