Barely Significant
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“a favorable trend”

1,336 sentences · 1,336 papers · 2,253 search hits before verification · confirmed specimen

Sighted at

p=0.09

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

92.5%; risk difference, -5.9% [95% CI: -15.8%-3.8%]); IRC-assessed PFS was similar with a favorable trend in zanubrutinib over orelabrutinib (HR, 0.74 [95% CI: 0.37-1.47]) and the 18-month PFS rate was numerically higher in zanubrutinib (82.9% vs. 78.7%).
Second, while the reduction in treatment-related SAEs showed a favorable trend, it did not reach statistical significance, and the estimate was based on a low absolute event rate (2 events in the short-course group vs. 10 in the long-course group); thus, the exact magnitude of this protective effect warrants cautious interpretation.