“a favorable trend”

PPP2R2A (F=0.416, p =0.66) also showed a favorable trend, whereas PTPN11 (SHP2) (F=9.33, p =0.394) was associated with shorter survival, consistent with its oncogenic role in RAS/MAPK and PI3K/AKT signaling ( 50 , 51 ).

During the follow-up, the experimental group exhibited a favorable trend toward sustained patency (Median Patency: Not Reached vs 13.0 months; p = 0.419).

Recommendation: Grade B Level of evidence: Moderate 1) Meta-analysis (1) In patients with LDH, surgical treatment significantly reduced leg pain (visual analogue scale [VAS] leg) at 6 months postsurgery compared with conservative treatment (mean difference=-2.40; 95% confidence interval [CI], -4.58 to -0.22; p=0.03); however, after 2 years, surgical treatment showed a favorable trend; nevertheless, the difference was not statistically significant (mean difference=-0.95; 95% CI, -3.47 to 1.56; p=0.46), indicating it did not significantly differ from conservative treatment ( Fig. 1A ).

Additionally, there was a favorable trend in the ORR (35.90% vs. 29.63%, P=0.46) and median PFS (14.53 vs. 7.03 months, P=0.10) ( Table S3 and Figure 3 ).

The interim OS data did not suggest a favorable trend for osimertinib over placebo (36‐month OS rate, 84% vs. 74%, HR = 0.81, P = 0.53), indicating that the long‐term efficacy of LAURA treatment remains unclear.

Objective response rate (ORR) to trastuzumab plus chemotherapy showed a favorable trend in patients with high TMB (75.0%, n=3/4) compared to patients with low TMB (59.3%, n=16/27) ( P =0.546).

There was no significant difference in change of zBMI between the intervention and control groups, although a favorable trend was observed (−0.016; 95% CI: −0.084, 0.051; p = 0.64).

A favorable trend towards DCD was described by Ruttens et al., 44 with a 5-year freedom from CLAD reported at 79.2% for DCD and 67.8% for DBD (p = 0.86).

For PFS, stratification by study design showed consistent results: retrospective studies (HR = 2.73, 95% CI: 1.58–4.73) and prospective studies (HR = 1.65, 95% CI: 0.87–3.15) both indicated a favorable trend toward TARE, with no significant subgroup effect ( P = 0.91).

Although there was a favorable trend, the study failed its primary composite endpoint (HR: 0.90; 95% CI: 0.78, p = 1.02).

A favorable trend in ARR reduction was observed vs.

Endovascular hypothermia based on revascularization with an invasive nature has shown a favorable trend in neuroprotection, while the high cost and demanding invasive operational procedure restrict its clinical application ( 37 ). 3.3 Improved neurological function by reducing splenic immune reaction with hypothermia Animal experiments found that systemic mild hypothermia can reduce the splenic immune response ( 31 ).

Therefore, although the NMA in this study indicated that interventions such as electroacupuncture were associated with a favorable trend for this indicator, these findings should be interpreted with caution and should not be over-generalized.

Although some studies suggest a favorable trend toward bioceramic sealers, the overall certainty of evidence remains moderate due to variability in follow-up periods (ranging from 6 to 24 months) and inconsistent methodologies for evaluating healing.

While not statistical significance, a favorable trend was observed in muscle-invasive UTUC cases (Fig.

The results posed that anakinra contributed to the improvement of systemic inflammatory, and NT-proBNP also posed a favorable trend after anakinra.

Though the outcome showed a favorable trend but did not reach statistical significance.

Although not statistically significant, this finding suggests a favorable trend regarding the intervention’s effectiveness.

Though larazotide acetate could not demonstrate a statistically significant efficacy in the reduction of intestinal permeability, a favorable trend was seen[ 82 ].

However, China stood out by achieving a negative contribution from epidemiological changes, a favorable trend that coincided with a period of significant primary care reforms and the implementation of national migraine guidelines.

Long‐term survival was comparable at 1 year, but a favorable trend for OPCAB emerged at 3 years, though it was not statistically significant.

By contrast, oncogenic driver identity provided outcome-relevant biological stratification independent of age: RET fusions, NTRK1/3 fusions, and BRAF V600E were associated with significantly higher odds of a non-excellent response after adjustment, whereas RAS-mutant tumors showed a favorable trend and DICER1-mutant cases achieved excellent outcomes in the modeled cohort.

CMT showed a favorable trend towards the NSAIDs group with a mean difference of 51.84 μm (95% CI: -15.23 to 118.91), although this was not statistically significant, with high heterogeneity (I^2 = 91%, P < 0.0001).

Conclusion: Passive smoking was responsible for 1.4% of all deaths in Brazil during the period 2009-2021 and showed a favorable trend, with rates decreasing by half during the period.

Nevertheless, the demonstration of a favorable trend in this regard is in line with reports by other authors [ 54 , 55 ].