“a favorable trend”

Although some primary endpoints, like SRI4, did not reach statistical significance, belimumab showed a favorable trend in disease control and a lower incidence of serious adverse events.

There are, therefore, the conditions for studying the effects of drugs acting on the mTOR system targeting autistic symptoms by themselves, also because rapamycin (acting as a selective mTOR inhibitor) has produced encouraging results on animals regardless of the presence of cortical tubers and epilepsy.[ 4 ] Mizuguchi et al .[ 5 ] carried out a randomized, double-blind, placebo-controlled trial, finding a favorable trend in autistic symptoms in a sample of children with tuberous sclerosis treated with everolimus (another selective mTOR inhibitor), but this trend was not supported by a statistical analysis of the data.[ 5 ] Overwater et al .[ 6 ] carried out another randomized, double-blind, placebo-controlled trial, finding no favorable cognitive or behavioral effects of everolimus in a sample of children with tuberous sclerosis.

In our cohort, we also observed a favorable trend in prognosis with KRAS/BRAF mutation, even in the KRAS G12D mutation, but there was no significant difference.

33 Conversely, a favorable trend was observed in a recent study published by Jernigan et al, which reported that the rate of multidrug-resistant PA infections among hospitalized patients decreased by 30% between 2012 and 2017 across 890 hospitals in the United States. 34 These data imply that the drug susceptibility pattern of PA changes with time, has geographic differences and should be updated regularly.

The primary endpoint was reported as non-significant despite a favorable trend, consistent with transparent reporting.

Keynote 412 study showed there was a favorable trend toward improved EFS in all the population, and improved OS for patients with CPS≧20, however there was still no significant difference.

Although this showed a favorable trend, the difference was not statistically significant.

EVs HSHS -H also demonstrated a favorable trend in reducing the mNSS, increasing rCBF in the sensory cortex, motor cortex, and striatum, and increasing cortical vascular density.

Children in Puerto Montt had the highest proportion classified in the healthy diet category, whereas those in Antofagasta had the lowest, indicating a favorable trend in southern Chile.

Within our institution, OS improved and PFS showed a favorable trend in the present cohort relative to PSM patients receiving definitive CRT ( Figure S6 ); however, no significant differences in PFS or OS were observed between the present cohort and the camrelizumab plus definitive CRT cohort ( NCT03671265 ), 7 though this comparison is limited by the latter's smaller sample size (n = 20) and the use of a higher radiotherapy dose (60 Gy).

Although the predefined clinical significance criteria were not fully met, the program demonstrated a favorable trend toward improved efficiency and patient-centered care.

Among efficacy measures, albumin was significantly more effective than the alternative treatments evaluated in resolving hyponatremia and PICD, whereas its effect on severe infection showed a favorable trend but was not significant.

CCRT-IO also significantly improved OS in pairwise meta-analyses, but this benefit did not reach statistical significance in the NMA, although a favorable trend was observed.

Also, a favorable trend was noted among Polish respondents participating in the Eurobarometer (2013,2016) surveys, which indicated an increase and sustainability of knowledge on the lack of antibiotic activity for viral infections and the ineffectiveness of their use in these situations [ 8 , 22 ].

While overall DRG revenue per case did not differ significantly between groups, a favorable trend toward higher reimbursement was noted in CytoSorb-treated patients with urosepsis ( Table 2 ).

Despite the development of TF showing a favorable trend, there was a very serious problem that plagued many research groups, which was its high pulverization ratio.

These findings confirm the presence of a favorable trend in the reduction of circumference over the time following Transform treatment.

Although OS data remained immature, a favorable trend was observed.

While there was no statistically significant difference in freedom from any atrial arrhythmia after a single procedure in the overall per-protocol population (HR, 0.81; 95% CI, 0.56–1.19), a favorable trend emerged after one or two procedures (HR, 0.62; 95% CI, 0.38–1.01) [ 17 ].

The above shows that the development of rice trade between China and the major rice-producing countries in Southeast Asia has been on a favorable trend.

Our children’s diets, on the contrary, showed a more appropriate intake of saturated and unsaturated fat after gluten exclusion with a favorable trend of the omega-6 to omega-3 ratio.

Besides, the more widespread use of other hypoglycemic drugs with proven cardiorenal benefits would have rendered it more difficult to reach a significance, even in the presence of a favorable trend, although it cannot be excluded that small differences between drugs in the class result in different outcomes.

After adjustment for cross-trial differences, the MAIC results showed a favorable trend for momelotinib vs.

The pooled SMD was 1.88 (95% CI: −0.41 to 4.18), indicating a favorable trend toward PRP.

Although no significant differences were observed in PFS or OS, the bevacizumab group showed a favorable trend.