“a favorable trend”

The FP regimen demonstrated a favorable trend (HR = 0.68; 95% CI: 0.25–1.87), though not statistically significant, suggesting a need for further validation.

Accordingly, we also noted significant decreases in IL-10 and GM-CSF, along with a favorable trend in TNFα levels.

In the long-term (>100 months) the Kaplan–Meier-graph of TBI and ICH/aSAH patients showed a favorable trend compared to patients with CP after ischemia.

In addition, we also found a favorable trend of SBP decreasing in the intervention groups, although the mean difference change in SBP was borderline-significant.

Five RCTs recruiting 269 cases with DED provided usable data on Schirmer’s test scores, 25 , 28 , 30 , 34 , 36 and pooled results showed no significant difference between the two groups, but a favorable trend for CsA over ATs (WMD 0.45, 95% CI −2.25 to 3.15).

Although no statistically significant survival benefit was observed, a favorable trend was noted in patients with poor prognostic features.

Our findings showed a statistically significant improvement in UCVA for the overall cohort, with the PKP subgroup achieving significance, while the LKP subgroup showed a favorable trend.

23 , 24 As a favorable trend, we showed improved survival rates over time, especially for patients with ISTAF, which supports our previous findings in the same cohort demonstrating a decrease in mortality in all patients with AF 25 and large epidemiological studies showing improved stroke survival rates during the past decade.

The AFFIRM-HF trial extended these findings to a high-risk population hospitalized with acute decompensated HF and LVEF <50%, revealing a favorable trend in reducing HF rehospitalizations and cardiovascular events.

However, major urban zones far from Milan (e.g., Brescia and Bergamo) just experience a marginal increase in growth and still show a favorable trend in time.

The HSC-preserving effect exerted by medium B and C was specific to the primitive stem cell pool, as no significant differences with the other media were observed in the MPP fraction; however, we did notice a favorable trend for media A and D in the preservation of MPPs after 6 days of culture, as already observed in Figure 1 ( Figure S2 B).

Although a favorable trend was observed, the results are inconclusive, and no reliable estimate of effect can be drawn. 4.1 Clinical relevance of the observed analgesic effect While the pooled analgesic effect of adjunctive tDCS reached statistical significance, its clinical relevance warrants careful interpretation.

Subgroup analysis also revealed a favorable trend in change from baseline STS at Week 4 with OC-01 versus vehicle across patient subgroups by randomization stratification factors at baseline ( eFig. 4 ).

Notwithstanding these still critical conditions, blood gas exchange had a favorable trend (P/F 220, 293, 320) and pressure support ventilation (PSV) was well-tolerated after percutaneous Griggs tracheotomy was still possible with acceptable laboratory coagulation values.

While low-intensity activities appeared to show a favorable trend, this finding should be interpreted with caution, given the limited number of studies and differences in study design.

Building on this, PACIFIC-5 demonstrated that durvalumab improved median PFS versus the effect of a placebo (14.0 versus 6.5 months, P = 0.038) in cCRT and sCRT subgroups among Chinese patients, with a favorable trend toward improved OS, reinforcing its role as a key consolidation strategy for this population [ 9 ].

Among females, total cancer mortality showed a favorable trend over the whole period in all the countries considered except Brazil, where the trend was stable.

Although the study was descriptive, the consistency of these findings suggests a favorable trend for PCR prostheses.

Additionally, in studies of droxidopa for the treatment of nOH, the rate of falls and fall-related adverse events demonstrated a favorable trend (but not statistically significant) in the groups of patients receiving droxidopa versus those receiving placebo [ 15 – 17 ].

However, with regard to PFS, a favorable trend was observed for DLL3-high tumors.

While OS data remain immature, early results suggest a favorable trend.

In spite of non-significant rise in awareness, treatment and control of hypertension in younger patients we had a favorable trend in this group; therefore more specific programs may be needed for this age group in the future.

While our meta-analysis did not identify a statistically significant difference in safety between the available surgical methods, minimally invasive surgery (MIS) demonstrated a favorable trend, with lower rates of intra-operative and post-operative complications, as well as a higher likelihood of achieving complete surgical staging with bilateral sentinel lymph node removal.

We found that mFOLFIRINOX was associated with significantly improved disease-free survival and a favorable trend toward better overall survival, independent of histological subtype.

The GeparNUEVO trial used durvalumab in the neoadjuvant setting for TNBC and observed an increase in pCR, improvement in iDFS and DDFS, and a favorable trend in OS [ 210 , 211 ].