Barely Significant

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highly significantP < 0.00010.0× alphaqualifiedgold
The mean divergence between VAS and WOMAC weight-bearing pain did not vary significantly with KL grade ( P = 0.72), but a highly significant trend was found for larger mean divergence in VAS and WOMAC non–weight-bearing pain with increasing KL grade ( P < 0.0001) (Figs. 3 A–C). 4.
highly significantP <0.00010.0× alphaqualifiedgold
Lastly, analysis of the relative usage of pAs in 182 genes that displayed significant modulation of at least two alternative pAs ( Supplementary Table S7 ) highlighted a highly significant negative correlation between the abundance of the two APA isoforms for most genes (92.85%; r = –0.8936, P <0.0001, Pearson correlation; Figure 2F ), thus confirming the effect on transcript lengthening induced by HT.
highly significantp < 0.00010.0× alphaqualifiedgold
However, in the replacement study designed to mimic the “real world” uncontrolled clinical practice setting, there was a highly significant (p < 0.0001) IOP effect when switching from the concomitant use of the individual components to the FCDT, as 81.1% patients had an IOP equal to or less than the starting IOP.
highly significantp < 0.00010.0× alphaqualifiedgold
We found a highly significant reduction in ovary mass (linear mixed model; t = − 4.37, df = 104, p < 0.0001) in failed queens across surveys (Supplementary Table S1 and Fig. 1 a), indicating that small ovaries are a widespread phenotype associated with poor fecundity, as described by beekeepers.
highly significantp < 0.00010.0× alphaqualifiedgold
Rat control on the farm A highly significant difference (χ 2 = 33.4543 p < 0.0001) was observed in the number of T. gondii positive animals among the properties that use cats for rat control (n = 239; 20 positive animals; prevalence 1.73%) and those that do not use them (n = 885; 12 positive 1 animals; prevalence 1.03%).
extremely significantp < 0.00010.0× alphaqualified
magna was higher than that in other stages ( Figure 2 ), and the expression of EmSAG10 (p < 0.0001) and EmSAG11 (p < 0.0001) in the merozoite stage was higher than that in the other stages ( Figure 2 ), the difference was extremely significant ( p < 0.0001). 2.4.
highly significantp<0.00010.0× alphaqualifiedgold
Results and Discussion In comparing methods of assessment of fungal growth on control media and media amended with fenbuconazole using inhibition ratios, the fixed effect Media*Day*Method was highly significant for Ratio 0 and Ratio A , having p-values of p<0.0001 (for Ratio 0 , F 23, 2033 = 259.27; for Ratio A , F 23, 2033 = 273.35).
highly significantp < 0.00010.0× alphaqualifiedgold
There is consistently more D1 dimensions in Group II as compared to Group I in each of interdental sites and these differences were found to be statistically significant for PM/CA, CA/LI and LI/CI while the difference was highly significant with CI/CI, CI/LI, LI/CA and CA/PM (p < 0.0001). 5 Discussion In search of definitive guidelines for attaining esthetics in relation to the proportionate existence of white and pink components, several clinical trials have been reported in the literature pertaining to PCA locations ( de Castro et al., 2006 , Sarver, 2004 ).