Excerpts

Epidemiological correlations We observed a highly significant correlation between having a psychiatric diagnosis and having an infection ( P = 2.16 × 10 −208 , OR = 1.72), including highly significant individual correlations between the specific psychiatric diagnoses and infection status (Table 1 ).

Of these, 843 genes were found in common with the previous set of genes differentially expressed in mutated samples (440 upregulated and 403 downregulated common genes in both sets), thus showing a highly significant overlap ( P =10 −206 ) between these analyses ( Figure 3 ).

Further, we observe that the converse comparison of off‐ > on‐milk genes to EPIT > placebo is also highly significant (OR 46.5; 95% CI [37.14, 58.22], P = 7.6e‐206, Figure 2f ).

However, here we found that ToxoNet exhibited a highly significant overlap in protein interactions with both T . brucei (283 common interactions, p = 6.4E-204) and Plasmodium (450 common interactions, p = 0; S6B Fig ).

Among the 12 genes related to hormone secretion, Vgf (nerve growth factor inducible) showed a highly significant increase in expression in GCGR-KO α-cells (Log 2 FC = 1.38; p = 2.21E-203) (Fig. 4a ).

Fewer TEs are derepressed in smc4-1 (286) than in met1 (956), but 63% (181 of 286) of these SMC4 -dependent TEs overlap with TEs derepressed in met1 , which is highly significant ( P = 3.60 × 10 −203 ) given an expectation of only 3.1% overlap by chance.

The difference was extremely significant ( p = 7E −202 ).

In the present study, we found a highly significant enrichment of long TRD sequences in RA compared to healthy individuals ( P = 7.91e − 202, Additional file 32 : Fig S7).

MM in the darkorange2 module was plotted ( Figure 4B ), in which the GS and MM had a highly significant correlation (cor =0.8, P < 1e−200).

Notably, chemical effects on cell-level SRPs were reliably detected across varying signature lengths, particularly in the UPR, where chemicals such as Brefeldin A, Cycloheximide, and Troglitazone exhibited highly significant length-dependent effects ( p < 1e-200) despite their small effect sizes.

This module contained 753 genes, which showed a highly significant association with nmSCs infiltration levels (Cor =0.88, P<1e−200; Figure 2C ).

Within the brown module, a highly significant correlation was observed between gene significance (GS) and module membership (MM) (correlation coefficient = 0.92, p < 1e − 200) (Fig. 2 D).

Only functional connections with highly significant t values for regression (with p<1e-200 or |t|>40, one-sample t-test) are shown since otherwise there are too many significant connections.

In total 689 genes appear in both lists, which represents a highly significant overlap ( P value <1E-200) (Figure 3a and Additional data file 2 , Table S2).

These tendencies were observed in both the 1645 group and the 239 group (data not shown) and were highly significant by Wilcoxon's rank-sum test (both of them showed P < 1e−200).

The analysis shows clear, highly significant (p-value < 1e-200) enrichment with matching FC signs between our SCZ analysis and reference PsychENCODE SCZ data (Supplementary Fig.

Each gene also has a highly significant methylation quantitative trait locus (meQTL) ( KIAA1804: p < 1e-200; ANAPC2: p < 3e-248), indicating that methylation levels at these CpG sites are driven by meQTL and fenofibrate.

This finding was further supported by scatter plots, which demonstrated a highly significant level of connectivity within the turquoise module (cor = 0.77, P < 1e-200, Fig. 3 E).

The stabilizing effects of 3AT that we observed at the single transcript level were also seen in a highly significant manner across the transcriptome (two-sided Wilcoxian paired test: p=1.165e-199) ( Figure 3H ).

An extremely significant locus ( P = 4.15 × 10 −198 ) centered at position 9.60 Mb on chromosome 14 ( Fig. 3A ) was identified.

A highly significant enrichment of Hsf1 binding sites was detected in the promoters of genes belonging to cluster 4 ( p < 10 −197 ; Table 1 ; Figure S6a in Additional file 11 ).

Steady state mRNA levels had a highly significant ( p < 10 −197 ) correlation with mRNA stability ( Fig. 2c ).

This trend is, again, present and highly significant in the experimental data ( 52 ) (logistic regression with two-tailed t -test, P = 1.5 × 10 − 195 , n = 7 , 311 ; Fig. 3 D , Right ).

The strong positive correlation between the cophenetic pairwise distances and proteomic dissimilarities is highly significant (rho = 0.6540, p-value = 1.9599e-195; r = 0.7291, p-value = 7.6776e-265), suggesting that the representative tree illustrates quite well the differences in the proteomic properties.

After controlling for read depth, we identified a highly significant enrichment of eQTLs among our ASEs ( p value = 2.65 × 10 −195 in putamen and 9.99 × 10 −111 in substantia nigra, using a randomisation approach—see Online Methods).