The shift for “No IC” and “Any IC” was also both highly significant ( p = 7.79406e–193 and p = 5.31155e–78, respectively) ( Table S3 ).
Excerpts
There is a highly significant positive correlation (r = 0.709, p = 8.98 × 10 −193 ) between the expected, real IC 50 values measured in the CCLE dataset and the values predicted by regression, based on the CGP dataset, which clearly confirms the validity of the prediction framework proposed here.
In addition to their propensity to be longer, proteins from the aggregation group also exhibited a higher relative frequency of methionines than random or dispersion proteins ( Figure 4 B), leading to a highly significant larger number of methionine residues per protein within the aggregation group, when compared to the dispersion ( p -value < 10 −192 , pairwise Wilcoxon rank sum test) or the random category ( p -value = 4 × 10 −192 , pairwise Wilcoxon rank sum test) ( Figure 4 C).
Consistent with our previous results, we found a small but highly significant enrichment of dDMPs becoming hypomethylated with cortex development ( n = 28,780 [56.5%], p = 1.61 × 10 −191 ) with the mean effect size being significantly greater for hypomethylated dDMPs than hypermethylated dDMPs (change in DNA methylation [%] per week: hypermethylated dDMPs = 1.03, hypomethylated dDMPs = −1.53, t test p < 1 × 10 −320 , Figure S3 ).
However, the correlation in expression of CD14 and K2 was highly significant (p = 8 x 10 −191 ) compared to that of CD19 and K2 (p = 0.065) at 1 dpi.
The p value of group discrimination evaluated by correlation on the first principal component (PC) axis was highly significant (p = 2.45 × 10 −190 ).
Out of the 6497 associations predicted by GLADIATOR, 301 true associations were recovered, resulting in a highly significant hypergeometric p value < 6e -186 .
50 With regard to the highly significant overlap ( P = 1.9E − 184) with the dataset comparing MDA-MB-231 cells vs MCF10A cells, it was striking that the majority of the 2385 overlapping gene features showed a negative correlation ( Fig. 2E ), indicating that more than 2/3 of the transcriptional alterations induced by low density cultivation of MCF10A cells overlapped significantly with MDA-MB-231 cells.
We found the DHCR7 lead SNP rs2852853 interacted with cohort (P = 2.0e-02) as well as gender (P = 2.6e-03), and the HLA-DQB1 lead SNP rs9275428 interacted with cohort (P = 6.1e-04), where cohort and gender were both highly significant environmental factors in the logistic regression models based on Equation 2 in the Methods section (P < 1.0e-183 and P < 1.0e-64 respectively).
This deviation is highly significant (χ 2 = 841.64, df = 2, P < 1.74 × 10 − 183 ) ( supplementary table S3 , Supplementary Material online).
To determine whether the overlap between the differentially expressed genes in FFPE RNA-Seq and FF microarrays in both datasets was not due to random association, we performed a hypergeometric test which revealed that the overlap was highly significant ( p < 10 -182 ) for both increased and decreased genes.
While about 8% of the worm genome is arranged antisense to another gene (Thierry-Mieg & Thierry-Mieg, 2006 ), approximately 35% of increased and decreased transcripts were arranged in this manner, representing a highly significant enrichment ( P = 5.3 × 10 −181 , hypergeometric distribution (hgd)) (Fig 1 B).
We found that the expression of 60% of sugar-responsive genes was also altered in dfoxoΔ flies, representing a highly significant overlap (p = 9.4 × 10 −181 ; Figure 2 ).
Although this overlap might not seem large, it is highly significant (Fisher’s exact test, p-value < 10 -180 ).
A One-Way ANOVA was performed, and the results indicate a highly significant difference between the ligand groups (P-value < 6.6718 × 10 −177 ).
This trend was confirmed across two additional independent sampling replicates ( n = 10,000 molecules per replicate), indicating that the effect is not attributable to stochastic variability. Across all runs, the improvement in QED at T = 0.6 remained highly significant (one-way ANOVA p < 10 –175 ; Kruskal–Wallis p < 10 –180 ), with a similarly significant reduction in structural alerts ( p < 10 –2 ).
The overlap between these two gene sets was highly significant (OR = 6.6, p = 6.61 × 10 −175 ).
A highly significant proportion (99.2%; sign test p = 1.47 × 10 −172 ) had the same direction of association across the two datasets ( Figure S3 ), and a large proportion (n = 337; 58.0%) satisfied the criteria for a pleiotropic association (p < 1.04 × 10 −6 and HEIDI p > 0.05) in the replication dataset as well.
Analysis of CpG sites positively correlated across all tissues revealed ‘nervous system development’ as a highly significant gene ontology (GO) term (P = 2.0 × 10 –171 ).
The results again indicated only minor differences between the young and old samples for most substructures, but revealed a robust and highly significant ( P = 2.0e‐171) hypermethylation of CpG islands in the old samples (Fig. 2 B).
As shown in Figure 1 A, one genome-wide highly significant associated position on BTA13 (ARS-BFGL-NGS-107931; position 63,500,701) was detected (−log 10 P -value = 167.56).
1d–g ), transcriptome profiling of two EwS cell lines after either knockdown of EWSR1-ETS or re-expression of TCF7L1 showed a highly significant ( P = 2.57 × 10 − 165 or P = 5.34 × 10 − 272 ) overlap of concordant DEGs (Supplementary Fig. 1e ).
To minimize false-positive hits, we filtered for the 2,071 peaks that overlapped in all three experiments and represented highly significant binding regions ( p < 1 × 10 −164 ; FDR <0.004; Tables 1 , Fig. 1 A ).
All of the African populations have higher T2D genetic risk than the European populations, and the difference between the African versus European ancestry group T2D genetic risk averages is highly significant ( t = 33.9, P = 1.4 × 10 −164 ).
All gene-set intersections for seam cells across methods were highly significant ( P ≤2.2×10 −162 with a Fisher's exact test), with 72.4% of the TaDa-defined seam cell genes at L2 and 79% of the L4 genes being present in the sci-RNA-seq dataset ( Fig.