Excerpts

The treatment effect was initially large, although after adding studies with large sample sizes, the confidence interval narrowed, and the treatment effect became smaller and stable, albeit the treatment effect was still highly significant (P<0.0001).

This confirmed modest though highly significant associations between circulating syndecan-1 and birthweight at 36 weeks’ (cohort 1; p < 0.0001; R 2 = 0.02, Supplementary Figure 1 E), and on the day of delivery in both the Melbourne (cohort 3; p < 0.0001 R 2 = 0.06, Supplementary Figure 1 F) and Chile cohorts (cohort 4; p = 0.0008, R 2 = 0.03, Supplementary Figure 1 G).

ANOVA results ( Table 1 ) indicated that the model was highly significant ( p < 0.0001), while the lack-of-fit was not ( p = 0.5908).

When paired samples of JIA PBMCs and SFMCs were analyzed, the reduced expression of CD73 on CD8+ T cells from the SF compared to the PB was highly significant ( P < 0.0001) (Figure 1 C).

Using a simple two-hit model to account for the difference in chromosome number, and the ratio of break points attributable to translocations and intrachromosomal rearrangements in mammals to estimate the expected number of translocations in nematodes, the failure to observe any validated translocation events in nematodes is highly significant ( p < 0.0001).

This effect was highly significant ( P < 0.0001) from the JA concentration of 2.5 μM for these both parameters.

Highly significant seroprevalence increases (p<0.0001) from children to younger adults (15–34 years) (but not from younger to older adults >34 years) were seen for mucosal α (HPV 16), γ (HPV 4, 65) and both μ PV (HPV 1, 63).

Response surface equations for peak sound pressure level (SPL peak) and effective sound pressure level (RMS) were constructed by a quadratic polynomial regression model with linear, interaction and quadratic terms, which was verified by analysis of variance (ANOVA) to be highly significant (p < 0.0001), as shown in equations (15) and (16) .

However, the test for residual heterogeneity remained highly significant (QE(df = 20) = 1017.9061, p < 0.0001), confirming substantial variability among studies.

A highly significant association was observed for rs1248923790 ( p < 0.0001, χ2 = 26.39). the TT genotype was significantly more common in disease cases (201) compared to controls (136), with an increased risk of disease (OR = 2.106, RR = 1.446, 95% CI: 1.249–1.679).

The loads exhibited highly significant difference ( P < 0.0001; analysis variance).

(2003) [ 57 ] documented a substantial and highly significant (p<0.0001) increase in hospitalization of replacement-fed infants compared with their breast-fed counterparts; several limitations were mentioned regarding the interpretation of the data.

The correlation of F rest with F ref was highly significant (HA 1: Spearman r = 0.92, p < 0.0001; HA 2: Spearman r = 0.84, p < 0.0001) and the regression lines were almost parallel to the bisector, indicating that F rest and F ref were tightly coupled (Fig. 5 ).

The overall trend was highly significant (p = 0.0001).

All investigated traits had a highly significant effect on longevity (P < 0.0001).

When we correlated the abundance of α-Syn with SNAP29 in post-mortem brain tissue, we found a highly significant negative correlation of the two proteins (slope = −0.1838 ± 0.03046; R 2 = 0.1013; P < 0.0001), suggesting that α-Syn exerts a dose-dependent effect on SNAP29 in the human SNc (Fig. 7e ).

137 A comparison of the in vitro release profiles of transferosome gels prepared using Polyoxyl 40 Hydrogenated Castor Oil and Span 60 surfactants revealed an extremely significant variation (p < 0.0001) in the curcumin release percentage after 6 and 48 h ( Figure 8B ).

A clear trend was observed: resource utilization width showed a negative correlation with MIP ( R 2 = 0.4901, p < 0.0001) and a positive correlation with MRO ( R 2 = 0.3465, p < 0.001) (Fig. 2c ).

Results The results demonstrated highly significant (p-value < 0.0001) predictive performance concerning the PHI, successfully distinguishing healthy subjects from those at high risk of disease.

In the case of cg02957270, a highly significant correlation was observed between methylation levels in the tumour and normal samples ( P < 0.0001).

The model for the time spent close to the feeding station for the animals that sensitised was highly significant explaining 60% of the variance (GLM, F 23, 111 = 9.12, p < 0. 0001, r 2 adj = 0.60).

Pathologic complete response was a highly significant predictor of DFS and OS in all treatment groups (HR = 0.45, P < 0.0001, and HR = 0.33, P < 0.0001, respectively).

The p values show that coefficients of the main effects are highly significant ( p < 0.0001), compared to the interaction effect.

The resulting linear regression equation, optimized for Amemiya Prediction Criterion, is highly significant (correlation coefficient = 0.787, r - 2 = 0.606 , P<0.0001, α = 0.05, see Fig 14 ).

Linear regression of seasonal curve shape against methodological score was highly significant ( r 2 = 0.3, F = 16.9, P < 0.0001, test for normality = 0.2, P < 0.0001) confirming that the tendency to demonstrate seasonal dynamics between the different retained studies depends largely on the degree of statistical or mathematical technical Sophistication of the study.