Excerpts

Such a non-uniform distribution is highly significant ( P <0.0001, Fisher exact test (75, 151; 204, 22)).

The increase was statistically highly significant ( χ 2 analysis for trend age vs. hypertension: P < 0.0001 in both sexes).

There was a highly significant difference in both mean ADC and mean rADC values between benign and malignant lesions (p < 0.0001 and p = 0.0002, respectively; Student’s t-test).

When analyzed as a mean of all GLU injections at the same dose, the oxygen increase was highly significant ( F (12,240) = 4.13 and F (12,900) = 5.33 for slow- and rapid time resolutions; p < 0.0001), it appeared with ~40-s latency after injection onset, and peaked 30–40 s after injection offset.

Not only are the correlations highly significant for infected implants in statistical terms (e.g., P <0.0001 for CCR5 + ITTP versus both Gag-p24 + ITTP and thymocyte viability), but the proportion of CCR5 + ITTP corresponds closely to that of infected ITTP ( Figure 4A ).

There was no difference in survival between diets in the IH flies, but there was a highly significant interaction (p<0.0001) in how the oxygen condition affected the flies on the two diets.

However, when PPC was provided ad libitum at 200 μg/mL, a highly significant suppression of the allergen-associated increase in total IgE levels was detected (Figure 2 , left panel, p < 0.0001).

of apoptotic cells from 20 μM to 120 μM compound concentration in MCF-7 breast cancer cells and it is highly significant at 100 μM and 120 μM in 5c ( P < 0.0001), 5g ( P < 0.0011, P < 0.0012), 5h ( P < 0.0001) and 5i ( P < 0.0004, P < 0.0010) treated MCF-7 cells ( Fig. 6 ).

The meta-regression of the year over logit-transformed prevalence showed a trend towards an increasing prevalence of beta-blocker use from 1995 to 2015 with a slope of 0.1 (p<0.0001).

ChatGPT-5 again had the highest score (71.67 ± 6.17), followed by DeepSeek-V3.2 (66.00 ± 5.07), Gemini (61.67 ± 5.88), and Claude Sonnet (59.00 ± 6.87), with a highly significant overall difference ( p < 0.0001).

Correlations were highly significant [tMax: minimum r(30) = 0.78; yMax: minimum r (30) = 0.93; p < 0.0001].

Analysis of all completers and withdrawals showed a strong trend over time ( p < 0.0001), and a difference in rate of change between groups (delayed-image: −0.50 kg, early-image: −0.27 kg, p = 0.0008).

In the entire PRDM9 protein of 894 amino acids, only 96 amino acids are in a DNA-binding turn-helix region (8 in each of 12 ZF domains), indicating a highly significant enrichment of nonsynonymous SNPs in turn-helix residues (24/31 vs. 96/894, P<0.0001 by Fisher's exact test).

A statistically highly significant correlation was found between changes in 99m Tc-Annexin V tumor uptake and clinical response (r 2 = 0.62; P < 0.0001).

The Tukey post hoc test between minutes 00–15 revealed highly significant changes for all the populations ( p < 0.0001) (Figures 4A , 5 ).

Quantitation of this data indicated a highly significant (p < 0.0001) increase in FRET efficiency after SENP6 knockdown compared to siNT-transfected cells as well as a larger distribution of the data ( Figure 6 E), suggesting variability in the structure of the foci.

When animals that received nerve injury or pharmacological block were pooled together (one-way ANOVA; F(3,60) = 7.3, p = 0.0003) the increased responsiveness reached significance already in the first protocol after deafferentation (Dunnett test; p = 0.0289), transiently lost significance in the second protocol (p = 0.12) and was again highly significant in the third protocol (p<0.0001).

The overall prognostic value of target status in MDST models was estimated via binomial testing of observed response variables (predicted versus unexpected) in all trials (talazoparib + trametinib) and found to be highly significant (80% correct prediction in n = 10 trials, P < 0.0001; fig.

Assessment of total GIPR protein levels in both males and female mice reflected the mRNA findings and depicted a highly significant decline in expression from P7 to P21 ( Fig 2H and 2K , males p<0.0001, females p<0.0001). 2.5 Correlations of protein expression with glucose levels and body weight To determine a potential role or link between receptor expression in the hypothalamus and functions in physiology in development, we analyzed correlations between postnatal blood glucose and body weight in males and females combined.

There were highly significant correlations ( r = 0.89, p < 10 –4 in Paris) and good intraclass correlation coefficients ( R = 0.89 in Paris) between the two series of values.

The P for trend remained highly significant across all models ( p < 0.0001).

This analysis showed an increasing trend for TPs using the filgrastim biosimilar (from 34.4% in July 2015 to 49.8% in June 2016; p < 0.0001) compared with a decreasing trend for TPs using lenograstim (from 22.6% in July 2015 to 12.3% in June 2016; p < 0.0001) and pegfilgrastim (from 26.8% in July 2015 to 20.6% in June 2016; p < 0.0001).

The differences in Kiss1 mRNA levels between hpg and age-matched WT females and males were found to be highly significant by two-way ANOVA (P<0.0001, both female and male) from day 30 onward (P<0.05; Bonferroni post-hoc).

In the small intestine, diabetic females exhibited a highly significant increase in iNOS compared to their controls ( p < 0.0001), while diabetic males showed a more moderate but significant elevation ( p < 0.01).

The differences are highly significant with logrank P -values <.0001.